Inventors:
Louise C. Showe - Media PA, US
Michael Showe - Media PA, US
Andrew V. Kossenkov - Philadelphia PA, US
Elena Nikonova - Swarthmore PA, US
International Classification:
C40B 30/04
C40B 40/06
C07H 21/02
Abstract:
Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.