Eric S Appel, 39203 Blackfoot Ln, Ventura, CA 93001

2010031, Dec 9, 2010

Jun 9, 2009

12/481477

James L. Hedrick - Pleasanton CA, US
Eric Appel - Palo Alto CA, US
Robert D. Miller - San Jose CA, US
Fredrik Nederberg - Greenville DE, US
Robert M. Waymouth - Palo Alto CA, US

C08F 283/02
C08G 73/02
C08G 18/62
C08F 283/14
C08G 18/00
C08F 283/00

525418, 525540, 525451, 525461, 525452, 525535, 525538, 525534

A method for making a multi-branched polymer includes reacting a first polymeric unit with a functional cyclic compound to form a functional macroinitiator compound with a cyclic moiety. The functional macroinitiator compound is reacted with an amine functional compound to open the cyclic moiety and form a first functional group and a second functional group. To form the branched polymer, at least one of a second polymeric unit is propagated from the first functional group and a third polymeric unit is propagated from the second functional group.

2021033, Nov 4, 2021

Oct 1, 2019

17/281014

- Stanford CA, US
Eric Andrew APPEL - Stanford CA, US
Mark DAVIS - Stanford CA, US
Emily C. GALE - Stanford CA, US
Santiago CORREA - Stanford CA, US

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - Stanford CA

A61K 39/21
A61K 9/06
A61K 47/69
A61K 39/015
A61K 39/145
A61K 39/39
A61P 35/00
A61P 31/16

An immunomodulatory delivery system includes a hydrogel, a first immunomodulatory cargo encapsulated in the cargo, and a second immunomodulatory cargo encapsulated in the hydrogel. The hydrogel includes a polymer non-covalently crossed-linked with a plurality of nanoparticles. The first immunomodulatory cargo is smaller than the second immunomodulatory cargo. A ratio of a diffusivity of the first immunomodulatory cargo through the hydrogel to a diffusivity of the second immunomodulatory cargo through the hydrogel is less than 3.

2018029, Oct 18, 2018

Oct 6, 2016

15/765585

- Cambridge MA, US
Eric Andrew Appel - Palo Alto CA, US
Robert S. Langer - Newton MA, US
Daniel Griffith Anderson - Framingham MA, US

Massachusetts Institute of Technology - Cambridge MA

A61K 47/54
A61K 38/28
A61K 47/68
A61K 38/26
A61K 47/60
C07K 16/28

The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

2018008, Mar 29, 2018

Sep 26, 2017

15/716500

- Palo Alto CA, US
Eric A. Appel - Palo Alto CA, US

C08K 3/36
C09K 21/02
C09K 21/14
A61L 27/02
A61L 27/20
A61L 27/52
A01N 25/10
A61K 9/06
A61K 47/38
A61K 47/02
A01N 25/04
B08B 9/032

The present invention provides moldable, fully scalable cellulose silica-based hydrogels for use as low-cost and safe carriers and aqueous viscosity modifiers in various industrial and medical applications.