Eric S Bornstein, 58Cedarhurst, NY

7470124, Dec 30, 2008

Apr 9, 2004

10/821442

Eric Bornstein - Natick MA, US

Nomir Medical Technologies, Inc. - Waltham MA

A61C 5/00

433 29, 433224, 606 16

A system and process for thermolytic eradication of bacteria and biofilm in the root canal of a human tooth involve an elongated and flexible optical probe and a laser oscillator that provides the probe with low infrared energy. The optical probe is sufficiently long for insertion into substantially the entire length of the root canal of the tooth. The optical probe causes lateral dispersion of the radiation from the probe throughout the root canal. The radiation is provided at an energy density and for a period of time that are necessary to selectively target bacteria and live biofilm in the dentinal tubules of an entire root canal system, at once, thereby (1) inhibiting creation of a blackbody “hot tip”, and (2) inducing laser interstitial thermotherapy (LITT) within the root-canal space.

7621745, Nov 24, 2009

Oct 8, 2004

10/961796

Eric Bornstein - Natick MA, US

Nomir Medical Technologies Inc. - Waltham MA

A61C 5/00
A61C 15/00
A61C 5/02
A61C 1/00

433215, 433 29, 433224

Provided herein are methods and compositions useful for the treatment of periodontal disease exploiting optical and thermal emissions of near-infrared laser systems and fibers in order to target chromophore-stained biofilm while minimizing damage to healthy tissues.

7713294, May 11, 2010

Oct 31, 2007

11/930941

Eric S. Bornstein - Natick MA, US

Nomir Medical Technologies, Inc. - Natick MA

A61B 5/06

607 88, 607 89

Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e. g. , loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.

8430919, Apr 30, 2013

Jul 13, 2011

13/182284

Eric Bornstein - Brooklyn NY, US

Nomir Medical Technologies, Inc. - Natick MA

A61N 5/06

607 88, 606 9

Optical methods and devices are provided for the reduction of the lipid content of adipocytes without significant heat or intolerable adverse effect on the cells and their surrounding tissues. The optical method and device can be used to irradiate adipose tissue through the skin with non-thermal and non-destructive effects by application of near infrared (NIR) irradiation at selected wave bands in selected ranges to affect modulation of innate enzymatic processes involved in lipolysis, lipogenesis, leptin secretion, adiponectin secretion, and/or glucose absorption.

8506979, Aug 13, 2013

Oct 31, 2007

11/981431

Eric Bornstein - Natick MA, US

Nomir Medical Technologies, Inc. - Natick MA

A61F 2/02

424422

Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.

8535359, Sep 17, 2013

May 19, 2008

12/123023

Eric Bornstein - Natick MA, US

Nomir Medical Technologies, Inc. - Waltham MA

A61N 5/06

607 88, 606 13, 606 14, 607 89

Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e. g. , loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.

2004012, Jul 1, 2004

Aug 26, 2003

10/649910

Eric Bornstein - Natick MA, US

A61L002/00
H01S005/00

422/022000, 372/043000

A dual wavelength laser in the low infrared electromagnetic spectrum is disclosed for destruction of bacteria via photo-damage optical interactions through direct selective absorption of optical energy by intracellular bacterial chromophores. The dual wavelength (NIMELS) laser includes an optical assembly and all associated components necessary for the housing of two distinct diode laser arrays (870 nm diode array and 930 nm diode array) that can be emitted through an output connector and wavelength multiplexer as necessary. With this preferred design, the dual wavelengths (870 nm and 930 nm) can be emitted singly, or multiplexed together to be conducted along a common optical pathway, or multiple optical pathways, to achieve maximal bacterial elimination.

2004015, Aug 12, 2004

Feb 11, 2004

10/776106

Eric Bornstein - Natick MA, US

A61N001/30
A61L002/00
H01S003/30

422/022000, 372/005000, 604/020000

Dual wavelength laser energy in the low infrared electromagnetic spectrum destroys bacteria via photo-damage optical interactions through direct selective absorption of optical energy by intracellular bacterial chromophores. The dual wave length laser system includes an optical assembly including two distinct diode laser ranges (870 nm diode array and 930 nm diode array) that can be emitted to achieve maximal bacterial elimination.