Eric Sing Yuen, 6979 Glen Oaks Ct, Old Bridge, NJ 08857

2007001, Jan 11, 2007

Jan 11, 2006

11/329757

Gerald Novak - Skillman NJ, US
Luc Truyen - Pennington NJ, US
Eric Yuen - Blue Bell PA, US

A61K 31/325

514483000, 514489000

This invention is directed to methods for controlling the duration of the depolarization and repolarization of the cardiac ventricle and therefore the QT interval, in therapeutically useful ways in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R, R, R, R, Rand Rare independently selected from the group consisting of hydrogen and C-Calkyl; wherein C-Calkyl is optionally substituted with phenyl, wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C-Calkyl, C-Calkoxy, amino, nitro and cyano.