Eugene D Cooper DeceasedCarlsbad, CA

8623412, Jan 7, 2014

Sep 23, 2003

10/528727

Vaghefi Farid - Burlington MA, US
Gary G. Liversidge - West Chester PA, US
Stephen B. Ruddy - Schwenksville PA, US
Eugene R. Cooper - Berwyn PA, US

Elan Pharma International Limited - Monksland Athlone County Westmeath

A61K 9/14
A61K 9/16
A61K 9/50
A61K 9/44

424484, 424490, 424498, 424502, 424 102

An abuse-resistant controlled release pharmaceutical composition comprising a pharmaceutically effective amount of discrete particles of an active capable of abuse, wherein surfaces of said particles are wetted with a water insoluble coating material, and preferably wherein said composition comprises a matrix, in which said particles are distributed, and which renders the abuse-capable compound within the matrix difficult to separate from the matrix; and a method for the preparation of a controlled release pharmaceutical composition having a reduced potential for abuse, comprising applying a pressure force to a mixture comprising a water insoluble material, and particles of a pharmaceutically active compound capable of inducing in a subject a reaction that is physiologically or psychologically detrimental if administered in an immediate release dosage form, thereby resulting in surface coated particles, and incorporating said surface coated particles into a pharmaceutical composition.