Frank Feng Gu, 682 Jennison Cir, Natick, MA 01760

2008008, Apr 3, 2008

May 15, 2007

11/803843

Frank Gu - Cambridge MA, US
Benjamin Teply - Omaha NE, US
Robert Langer - Newton MA, US
Omid Farokhzad - Chestnut Hill MA, US

Massachusetts Institute of Technology - Cambridge MA
The Brigham & Women's Hospital, Inc. - Boston MA

A61K 9/14
A61K 38/43
C40B 50/00
A61K 47/32

424489000, 424094100, 506023000, 514772400

The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.

2010001, Jan 21, 2010

Jul 6, 2007

12/309049

Jeffrey M. Karp - BROOKLINE MA, US
Alireza Khademhosseini - Cambridge MA, US
David A. Berry - Brookline MA, US
Robert S. Langer - Newton MA, US
Frank X. Gu - Cambridge MA, US

Massachusetts Institute of Technology - Cambridge MA

A61K 8/24
C01B 25/32
B32B 5/16
A61K 33/42
A61Q 11/00
A61P 19/10

424 57, 423308, 428402, 424602

Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.

2010002, Jan 28, 2010

Jun 22, 2007

12/306249

Rohit Karnik - Cambridge MA, US
Frank X. Gu - Cambridge MA, US
Pamela Basto - Somerville MA, US
Chris Cannizzaro - Cambridge MA, US
Alireza Khademhosseini - Cambridge MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US

C08J 3/14
B01J 2/00

523105, 4222451

The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.