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Frank E Blecha, 48Woodmoor, CO

Known as:
Frank T Blecha Frank Bleha
Related to:
George Taylor 55

Frank Blecha Phones & Addresses

Monument, CO   

Colorado Springs, CO   

Manhattan, KS   

507 La Melodia Dr, Las Cruces, NM 88011   

734 City View Dr, Las Cruces, NM 88011   

Nampa, ID   

19475 Doewood Dr, Monument, CO 80132   

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Frank E Blecha

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Position: Clerical/White Collar

Education

Degree: Associate degree or higher
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Frank Blecha

Publications & IP owners

Us Patents

Synthetic Peptides That Inhibit Leukocyte Superoxide Anion Production And/Or Attract Leukocytes

US Patent:
6713605, Mar 30, 2004
Filed:
Oct 8, 1997
Appl. No.:
08/930777
Inventors:
Frank Blecha - Manhattan KS
Jishu Shi - Los Angeles CA
Assignee:
Kansas State University Research Foundation - Manhattan KS
International Classification:
C07K 1400
US Classification:
530324, 530300, 514 12
Abstract:
Methods of inhibiting leukocyte O production and attracting luekocytes using specific peptides are disclosed. Theses peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These peptides can be used as medicaments that fight infection by attracting leukocytes to a wound site, yet restrict tissue damage at the wound site caused by excessive oxygen radicals produced by these leukocytes.

Synthetic Peptides That Inhibit Leukocyte Superoxide Anion Production And/Or Attract Leukocytes

US Patent:
7049396, May 23, 2006
Filed:
Dec 7, 2001
Appl. No.:
10/014147
Inventors:
Frank Blecha - Manhattan KS, US
Jishu Shi - Los Angeles CA, US
Assignee:
Kansas State University Research Foundation - Manhattan KS
International Classification:
C07K 7/08
US Classification:
530326, 530324, 530325, 514 2, 514 12, 514 13
Abstract:
Methods of inhibiting leukocyte O production and attracting leuckocytes using specific peptides are disclosed. These peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These peptides can be used as medicaments that fight infection by attracting leukocytes to a wound site, yet restrict tissue damage at the wound site caused by excessive oxygen radicals produced by these leukocytes.

Antimicrobial Cathelicidin Peptides

US Patent:
7985832, Jul 26, 2011
Filed:
Dec 29, 2006
Appl. No.:
12/087228
Inventors:
Tonatiuh Melgarejo - Manhattan KS, US
Frank Blecha - Manhattan KS, US
Yongming Sang - Manhattan KS, US
Maria Teresa Ortega - Manhattan KS, US
Assignee:
Kansas State University Research Foundation - Manhattan KS
International Classification:
A61K 38/00
A61K 38/17
A61P 31/00
A01N 37/18
C07K 14/00
C07K 16/00
C07K 17/00
C07K 2/00
C07K 4/00
C07K 7/00
C07K 5/00
US Classification:
530300, 530324, 514 22, 514 23
Abstract:
The invention relates to antimicrobial cathelicidin polypeptides related to a 38 amino acid peptide having SEQ ID NO:4. The invention provides for polypeptides having broad spectrum antimicrobial activity, nucleic acids and expression vectors encoding such polypeptides, as well as host cells and methods of reducing survival of a microbe. In addition, the invention also provides compositions, as well as articles of manufacture, that comprise a broad spectrum antimicrobial polypeptide.

Synthetic Peptides That Inhibit Leukocyte Superoxide Anion Production And/Or Attract Leukocytes

US Patent:
2004004, Mar 4, 2004
Filed:
Aug 28, 2003
Appl. No.:
10/651147
Inventors:
Frank Blecha - Manhattan KS, US
Jishu Shi - Los Angeles CA, US
International Classification:
A61K038/17
US Classification:
514/012000
Abstract:
Methods of inhibiting leukocyte O production and attracting leuckocytes using specific peptides are disclosed. These peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These peptides can be used as medicaments that fight infection by attracting leukocytes to a wound site, yet restrict tissue damage at the wound site caused by excessive oxygen radicals produced by these leukocytes.

Synthetic Antimicrobial Peptide

US Patent:
5830993, Nov 3, 1998
Filed:
Apr 10, 1995
Appl. No.:
8/419066
Inventors:
Frank Blecha - Manhattan KS
Jishu Shi - Manhattan KS
Assignee:
Kansas State University Research Foundation - Manhattan KS
International Classification:
A61K 3800
C07K 1400
US Classification:
530300
Abstract:
New antimicrobial truncated peptides are disclosed which are based upon a known peptide, PR-39 (SEQ ID NO: 1) but which contain a lesser number of amino acid residues yet still retain antimicrobial activity. The most preferred peptide compound is PR-26, SEQ ID NO: 2. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention.

Peptide Modulation Of Reperfusion Injury

US Patent:
6133233, Oct 17, 2000
Filed:
Feb 16, 1998
Appl. No.:
9/024975
Inventors:
Christopher R. Ross - Manhattan KS
Frank Blecha - Manhattan KS
Jishu Shi - Los Angeles CA
Assignee:
Kansas State University Research Foundation - Manhattan KS
International Classification:
A61K 3816
US Classification:
514 12
Abstract:
An in vivo method of reducing reperfusion injury in a mammal resulting from reperfusion of a temporarily occluded blood vessel which comprises the steps of administering into the mammal's bloodstream an effective amount of a proline /arginine rich peptide such as PR-39 (SEQ ID NO: 1). The method has particular application in surgical procedures such as coronary bypass and organ transplantation surgery and where reperfusions occur subsequent to a spontaneous occlusion. Preferred peptides have up to about 50 amino acid residues with a plurality of --PXXP-- sequences.

Isbn (Books And Publications)

Immunomodulation In Domestic Food Animals

Author:
Frank Blecha
ISBN #:
0120392356

Possible Relatives

Debra Blecha  Diane M Blecha  Henry J Blecha  James R Blecha  Janeth Blecha  Jessica Blecha  Joel M Blecha  Frank R Johnson  Frank J Stanco  Frank W Johnston 

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