Frank F Shi, 62814 Windridge Ln, Downingtown, PA 19335
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814 Windridge Ln, Downingtown, PA 19335 610-5187660
Exton, PA
New York, NY
Madison, WI
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Us Patents
Dimeric High Affinity Egfr Constructs And Uses Thereof
US Patent:
8278415, Oct 2, 2012
Filed:
Dec 20, 2007
Appl. No.:
12/514631
Inventors:
Wang Bryan - Wyomissing PA, US
Frank Shi - Downingtown PA, US
Juliane Mills - Wallingford PA, US
Frank Shi - Downingtown PA, US
Juliane Mills - Wallingford PA, US
Assignee:
Centocor, Inc. - Malvern PA
International Classification:
C07K 14/00
US Classification:
530350
Abstract:
Polypeptides comprising EGFR extracellular domains I-III capable of forming dimeric EGF-binding proteins are provided. The dimeric construct of the invention is useful in applications where high affinity EGF binding is desired and can be used to select agents capable of binding to native EGFR in the presence of EGF.
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