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Frank James Sorgi, 65Butler, NJ

Known as:
Frank J Sorgi Frank P Sorgi Frank M Sorgi Frank F Sorgi Terri L Sorgi Frank J Sorge
Related to:
Melinda Sorgi

Frank Sorgi Phones & Addresses

Butler, NJ   

Marlton, NJ   

Barnegat, NJ   

Manahawkin, NJ   

34 Lake Dr, Randolph, NJ 07869    973-5846939   

Riverdale, NJ   

Wayne, NJ   

Oak Ridge, NJ   

Watson, LA   

Pompton Lakes, NJ   

34 Lake Dr, Randolph, NJ 07869    973-9060953   

Work

Position: Clerical/White Collar

Education

Degree: High school graduate or higher
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Publications & IP owners

Us Patents

Delivery System For Gene Therapy To The Brain

US Patent:
6436708, Aug 20, 2002
Filed:
Feb 8, 1999
Appl. No.:
09/202564
Inventors:
Paola Leone - Philadelphia PA, 19107
Matthew J. During - Philadelphia PA, 19147
Frank L. Sorgi - Sonoma CA, 95476
International Classification:
C12N 1588
US Classification:
435458, 514 44, 4353201, 435455, 424450
Abstract:
A gene delivery system which. is both safe and results in long-term expression throughout the brain has been developed. A lipid-entrapped, polycation-condensed DNA (LPD) system has been developed for brain gene delivery, using an adeno-associated vial. (âAAVâ) vector in which the transcription unit is flanked by the 145 bp inverted terminal repeats (ITR) of the adeno-associated virus. This AAV plasmid is more effective than a non-ITR containing plasmid in vivo. The results show that the LPD-AAV plasmid complexes efficiently transduce neurons and that gene expression can persist for over 10 months in the brain. Furthermore, the intraventricular delivery method with systemic hyperosmolality results in global gene delivery. The examples show that expression of the human aspartoacyclase (âASPAâ) gene in children with this metabolic disorder can be obtained over a period of many months to a year, with functional activity.

Possible Relatives

Gabriel A Sorgi  James E Sorgi  Kevin G Sorgi  Marco V Sorgi  Michelle L Sorgi  Paul J Sorgi  Andrea N Sorgi  Frank R Johnson  Frank J Stanco  Frank W Johnston 

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