Geoffrey L Wilson, 5254 University Rd, Brookline, MA 02445

6396484, May 28, 2002

Sep 29, 1999

09/408818

Robert Adler - Northbrook IL
Arie Ravid - Newark CA
Geoffrey D. Wilson - Oxnard CA

Elo Touchsystems, Inc. - Fremont CA

G09G 500

345177, 345173, 345176

A method and apparatus for adapting an acoustic touchscreen controller to the operating frequency requirements of a specific touchscreen are provided. The adaptive controller can either utilize look-up tables to achieve the desired output frequency or the it can use a multi-step process in which it first determines the frequency requirements of the touchscreen, and then adjusts the burst frequency characteristics, the receiver circuit center frequency, or both in accordance with the touchscreen requirements. In one embodiment, the adaptive controller compensates for global frequency mismatch errors. In this embodiment a digital multiplier is used to modify the output of a crystal reference oscillator. The reference oscillator output is used to control the frequency of the signal from the receiving transducers and/or to generate the desired frequency of the tone burst sent to the transmitting transducers. In another embodiment that is intended to compensate for both global and local frequency variations, the adaptive controller uses a digital signal processor.

6403354, Jun 11, 2002

Jan 19, 2001

09/766055

James Samuelson - Danvers MA
John Pelletier - Amesbury MA
Marion Sibley - Beverly MA
Geoffrey G. Wilson - Boxford MA

New England Biolabs, Inc. - Beverly MA

C12N 922

435199, 4352523, 4353201, 536 232

The present invention relates to recombinant DNA which encodes the BstYI restriction endonuclease as well as BstYI methyltransferase, expression of BstYI restriction endonuclease and M. BstYI in cells containing the recombinant DNA. It also relates to methods for purification of the recombinant BstYI restriction endonuclease and BstYI methyltransferase.

6630929, Oct 7, 2003

Sep 29, 1999

09/408594

Robert Adler - Northbrook IL
Joel Kent - Fremont CA
Jeffrey L. Sharp - Ruckersville VA
Geoffrey D. Wilson - Oxnard CA

ELO Touchsystems, Inc. - Fremont CA

G09G 500

345177, 345173, 345176, 178 1804

A method and apparatus for adapting an acoustic touchscreen controller to the operating frequency requirements of a specific touchscreen are provided. The adaptive controller can either utilize look-up tables to achieve the desired output frequency or the it can use a multi-step process in which it first determines the frequency requirements of the touchscreen, and then adjusts the burst frequency characteristics, the receiver circuit center frequency, or both in accordance with the touchscreen requirements. In one embodiment, the adaptive controller compensates for global frequency mismatch errors. In this embodiment a digital multiplier is used to modify the output of a crystal reference oscillator. The reference oscillator output is used to control the frequency of the signal from the receiving transducers and/or to generate the desired frequency of the tone burst sent to the transmitting transducers. In another embodiment that is intended to compensate for both global and local frequency variations, the adaptive controller uses a digital signal processor.

7081358, Jul 25, 2006

Aug 16, 2002

10/223074

Daniel Heiter - Groveland MA, US
Keith Lunnen - Essex MA, US
Geoffrey G. Wilson - Boxford MA, US

New England Biolabs, Inc. - Ipswich MA

C12N 15/55
C12N 9/22

435199, 4352523

Methods are provided for converting into a sequence specific strand specific and location specific DNA nicking endonuclease, a restriction endonuclease that recognizes an asymmetric DNA sequence, the endonuclease having two catalytic sites and one or more single sequence specific DNA-binding domains. In one embodiment the method requires inactivating one of the catalytic sites of the restriction endonuclease. In another embodiment, the restriction endonuclease is a dimer having a first and second subunit each comprising a sequence specific DNA binding domain, a catalytic site and a dimerization domain. The nicking endonuclease is formed from combining one subunit having an inactivated catalytic site and a second subunit having an inactivated DNA binding domain. The nicking endonuclease may be converted into a restriction endonuclease by the addition of manganese cations in the digestion buffer.

7795408, Sep 14, 2010

Jun 14, 2007

11/818298

Keith Lunnen - Essex MA, US
John Greci - Manchester MA, US
Geoffrey Wilson - South Hamilton MA, US

New England Biolabs, Inc. - Ipswich MA

C07H 21/02
C07H 21/04
C12P 21/06
C12N 1/20
C12N 15/74

536 231, 435471, 435 691, 4352523

An isolated DNA is provided which encodes a protein that is capable of binding to 5′GGTACC-3′, the isolated DNA being capable of hybridizing to SEQ ID NO:3 under stringent hybridization conditions. The isolated DNA may be alternatively characterized as coding for a protein having an amino acid sequence comprising SEQ ID NO:5 or by an amino acid sequence with an expectation value of less than E=ein a BLAST search using SEQ ID NO:5. Vectors containing the isolated DNA and host cells expressing the vectors as well as a method for making recombinant Acc65I having the above properties are also provided.

2003021, Nov 13, 2003

Nov 14, 2002

10/276289

Huimin Kong - Wenham MA, US
Lauren Higgins - Rockport MA, US
Michael Dalton - Manchester MA, US
Rebecca Kucera - Hamilton MA, US
Ira Schildkraut - Cerrillos NM, US
Geoffrey Wilson - Boxford MA, US

C12Q001/68
C07H021/04
C12P019/34
C12N009/22
C12N001/21
C12P021/02
C12N015/74

435/006000, 435/091200, 536/023200, 435/320100, 435/252300, 435/069100, 435/199000

The present invention relates to recombinant DNA which encodes a novel nicking endonuclease, N.BstNBI, and the production of N.BstNBI restriction endonuclease from the recombinant DNA utilizing PleI modification methylase. Related expression vectors, as well as the application of N.BstNBI and other nicking enzymes in non-modified strand displacement amplification, is disclosed also.

2007016, Jul 19, 2007

Mar 23, 2005

10/593790

Richard Morgan - Middleton MA, US
Geoffrey Wilson - South Hamilton MA, US
Keith Lunnen - Essex MA, US
Daniel Heiter - Groveland MA, US
Jack Benner - South Hamilton MA, US
Celine Nkenfou - Yaounde, CM
Stephen Picone - Beverly MA, US

New England Biolabs, Inc. - Ipswich MA

C12Q 1/68
C07H 21/04
C12P 21/06
C12N 9/22
C12N 15/74
C12N 1/21

435006000, 435069100, 435199000, 435252330, 435488000, 536023200

A novel restriction endonuclease and methods of making the same are obtainable from either species 2144 (NEB#1398) or the recombinant stain (NEB#1554) which cleaves at nt sequence 5′-CAANNNNNGTGG-3′ (SEQ ID NO:14) in double-stranded DNA molecules. The novel restriction endonuclease is a modular protein in which the specificity moiety is an independent module from the restriction-modification module.

2012015, Jun 21, 2012

Aug 25, 2010

13/392286

Jurate Bitinaite - Rowley MA, US
Romualdas Vaisvila - Ipswich MA, US
Sriharsa Pradhan - Wenham MA, US
Yu Zheng - Topsfield MA, US
Richard J. Roberts - Wenham MA, US
Christopher Noren - Boxford MA, US
Elisabeth A. Raleigh - Somerville MA, US
Geoffrey Wilson - South Hamilton MA, US

NEW ENGLAND BIOLABS, INC. - Ipswich MA

C12Q 1/68

435 611

Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.