Inventors:
Michele Potashman - Cambridge MA, US
Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Joseph L. Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - San Diego CA, US
Jean-Christophe Harmange - Andover MA, US
George Borg - Somerville MA, US
Matthew Weiss - Boston MA, US
Brian L. Hodous - Cambridge MA, US
Russell Graceffa - Hampton NH, US
William H. Buckner - Kittery ME, US
Craig E. Masse - Cambridge MA, US
Deborah Choquette - Medford MA, US
Matthew W. Martin - Arlington MA, US
Julie Germain - Quebec, CA
Lucian V. DiPietro - Gloucester MA, US
Stuart C. Chaffee - Boston MA, US
Joseph J. Nunes - Andover MA, US
John L. Buchanan - Newton MA, US
David C. McGowan - Brussels, BE
Douglas A. Whittington - Waltham MA, US
Gregory J. Habgood - Merrimac MA, US
Vinod F. Patel - Acton MA, US
Daniel La - Brookline MA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/04
Abstract:
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.