Career records & work history
Medicine Doctors
George Chengalathu Gettys
Specialties:
Psychiatry
George Richard Gettys, 68Payson, UT
George Gettys Phones & Addresses
Elk Ridge, UT
8355 Newbridge Way, Citrus Heights, CA 95610 916-7259259
Fair Oaks, CA
Mentions for George Richard Gettys
Publications & IP owners
Us Patents
Process For Halomethyl Ethers Of Hydroxyiminomethyl Quaternary Pyridinium Salts
US Patent:
RE41898, Oct 26, 2010
Filed:
Nov 19, 2008
Appl. No.:
12/274133
Inventors:
George R. Gettys - Citrus Heights CA, US
Olivier Dapremont - Citrus Heights CA, US
Olivier Dapremont - Citrus Heights CA, US
Assignee:
Aerojet Fine Chemicals LLC - Rancho Cordova CA
International Classification:
C07D 401/02
US Classification:
546256, 546329
Abstract:
A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces the halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropanein high yield and purity, which facilitates its use as an intermediate in the manufacture of an asymmetrically substituted 1,3-di(1-pyridino)-2-oxapropane, a class of compounds that are generally useful antidotes to various toxic agents. A prominent member of the class is the dimethylsulfonate salt of 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane. The use of mercaptoalkyl-functionalized polymers is disclosed as a preferred metal ion scavenger for a final purification step in the manufacture of these compounds.
Process For Halomethyl Ethers Of Hydroxyiminomethyl Quaternary Pyridinium Salts
US Patent:
2006018, Aug 17, 2006
Filed:
May 19, 2005
Appl. No.:
11/133740
Inventors:
George Gettys - Citrus Heights CA, US
Olivier Dapremont - Citrus Heights CA, US
Aslam Malik - Cameron Park CA, US
Olivier Dapremont - Citrus Heights CA, US
Aslam Malik - Cameron Park CA, US
Assignee:
AEROJET FINE CHEMICALS LLC, a Delaware limited liability company - Rancho Cordova CA
International Classification:
A61K 31/44
US Classification:
514334000
Abstract:
A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces the halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane in high yield and purity, which facilitates its use as an intermediate in the manufacture of an asymmetrically substituted 1,3-di (1-pyridino)-2-oxapropane, a class of compounds that are generally useful antidotes to various toxic agents. A prominent member of the class is the dimethylsulfonate salt of 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane. The use of mercaptoalkyl-functionalized polymers is disclosed as a preferred metal ion scavenger for a final purification step in the manufacture of these compounds.
Process For Halomethyl Ethers Of Hydroxyiminomethyl Quaternary Pyridinium Salts
US Patent:
2006024, Nov 2, 2006
Filed:
Feb 17, 2005
Appl. No.:
11/061064
Inventors:
Aslam Malik - Cameron Park CA, US
George Gettys - Citrus Heights CA, US
George Gettys - Citrus Heights CA, US
Assignee:
AEROJET FINE CHEMICALS LLC, a Delaware limited liability company - Sacramento CA
International Classification:
A61K 31/44
A61K 31/455
C07D 213/46
A61K 31/455
C07D 213/46
US Classification:
514355000, 514357000, 546315000, 546329000
Abstract:
A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces the halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane in high yield and purity, which facilitates its use as an intermediate in the manufacture of an asymmetrically substituted 1,3-di(1-pyridino)-2-oxapropane, a class of compounds that are generally useful antidotes to various toxic agents. A prominent member of the class is the dimethylsulonate salt of 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane.
Process For Halomethyl Ethers Of Hydroxyiminomethyl Quaternary Pyridinium Salts
US Patent:
2008027, Nov 6, 2008
Filed:
Jul 15, 2008
Appl. No.:
12/173596
Inventors:
George R. Gettys - Citrus Heights CA, US
Olivier Dapremont - Citrus Heights CA, US
Aslam A. Malik - Cameron Park CA, US
Olivier Dapremont - Citrus Heights CA, US
Aslam A. Malik - Cameron Park CA, US
Assignee:
Aerojet Fine Chemicals LLC. - Rancho Cordova CA
International Classification:
C07D 213/02
US Classification:
546334
Abstract:
A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces the halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane in high yield and purity, which facilitates its use as an intermediate in the manufacture of an asymmetrically substituted 1,3-di(1-pyridino)-2-oxapropane, a class of compounds that are generally useful antidotes to various toxic agents. A prominent member of the class is the dimethylsulfonate salt of 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane. The use of mercaptoalkyl-functionalized polymers is disclosed as a preferred metal ion scavenger for a final purification step in the manufacture of these compounds.
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