George L Grantham, 73Mount Olive, NC

6448046, Sep 10, 2002

Nov 28, 2000

09/726651

Jon Donson - Davis CA
William O. Dawson - Winter Haven FL
George L. Grantham - Riverside CA
Thomas H. Turpen - Vacaville CA
Ann M. Turpen - Vacaville CA
Stephen J. Garger - Vacaville CA
Laurence K. Grill - Vacaville CA

Large Scale Biology Corporation - Vacaville CA

C12N 1511

435 701, 435 691, 435455, 435456, 435325, 4352351, 4353201, 536 231, 536 241

The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.

7192740, Mar 20, 2007

Oct 24, 2002

10/280725

Jonathan Donson - Oak Park CA, US
William O. Dawson - Winter Haven FL, US
George L. Grantham - Riverside CA, US
Thomas H. Turpen - Vacaville CA, US
Ann Myers Turpen - Vacaville CA, US
Laurence K. Grill - Vacaville CA, US

Large Scale Biology Corporation - Vacaville CA

C12P 21/02
C12P 21/06
C12N 15/00
C12N 15/74

435 701, 435 691, 4353201, 435325, 4352351, 435455, 435456, 536 231, 536 241

The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.

5889190, Mar 30, 1999

Jun 7, 1995

8/480432

Jon Donson - Davis CA
William O. Dawson - Winter Haven FL
George L. Grantham - Riverside CA
Thomas H. Turpen - Vacaville CA
Ann Myers Turpen - Vacaville CA
Stephen J. Garger - Vacaville CA
Laurence K. Grill - Vacaville CA

Biosource Technologies, Inc. - Vacaville CA

A01H 500
C12N 1540
C12N 1582
C12N 1583

800288

The present invention is directed to recombinant plant viral nucleic acids and to hosts infected thereby. The recombinant plant viral nucleic acids comprise a native plant viral subgenomic promoter, at least one non-native plant viral subgenomic promoter, a plant viral coat protein coding sequence, and optionally, at least one non-native nucleic acid sequence to be transcribed or expressed in the infected host plant. The recombinant plant viral nucleic acids are stable, capable of systemic infection and capable of stable transcription or expression in the plant host of the non-native nucleic acid sequences.

6284492, Sep 4, 2001

Jun 7, 1995

8/483502

Jon Donson - Davis CA
William O. Dawson - Winter Haven FL
George L. Grantham - Riverside CA
Thomas H. Turpen - Vacaville CA
Ann M. Turpen - Vacaville CA
Stephen J. Garger - Vacaville CA
Laurence K. Grill - Vacaville CA

Large Scale Biology Corporation - Vacaville CA

C12N 1511
C12N 1509
C12P 2100

435 701

The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.