Inventors:
Joel M. Friedman - South Orange NJ, US
Adam J. Friedman - New York NY, US
George Han - Bronx NY, US
Mahantesh S. Navati - Bronx NY, US
Kevin P. Davies - New York NY, US
Moses Tarndie Tar - Bronx NY, US
Alan A. Alfieri - Garden City NY, US
Arturo Casadevall - New Rochelle NY, US
Ekaterina Dadachova - Mahopac NY, US
Helene C. Eisenman - Astoria NY, US
David Spray - Pelham NY, US
Assignee:
Albert Einstein College of Medicine of Yeshiva University - Bronx NY
International Classification:
A61K 49/00
A61K 33/00
A61K 38/18
A61K 51/12
A61K 47/36
A61K 47/34
A61K 47/24
A61K 49/18
A61K 9/00
A61K 9/50
A61P 35/00
A61P 31/04
A61P 29/00
A61P 15/10
A61P 39/00
A61K 38/02
US Classification:
424 125, 514 11, 424718, 514 76, 424 96, 514777, 514772, 424 93, 424400, 424493, 424490
Abstract:
The invention provides compositions for controlled delivery and/or containment of therapeutic and/or diagnostic agents comprising the agent or agents encapsulated by a matrix containing chitosan, polyethylene glycol (PEG) and/or polyvinyl alcohol (PVA), and tetra-methoxy-ortho-silicate (TMOS) or tetra-ethoxy-ortho-silicate (TEOS), as well as methods for preparing the compositions, and uses of the compositions for therapy and imaging.