George J Todaro, 89Seattle, WA

4816561, Mar 28, 1989

Sep 17, 1985

6/777016

George J. Todaro - Seattle WA

C07K 710
C07K 708

530324

Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides, which exhibit cell growth promoting properties are disclosed, as well as a process for isolating the TGF polypeptides from both human and murine cell lines in homogeneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligipeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certain cell lines into a cancerous state. Compositions and methods based on the disclosed peptides for detection and treatment of cancer and other proliferative diseases and for cell or tissue growth associated treatment, e. g. , wound healing, ulcer therapy and bone loss are also described.

5011777, Apr 30, 1991

Jun 29, 1990

7/546248

Mohammed Shoyab - Seattle WA
Hans Marquardt - Mercer Island WA
George J. Todaro - Seattle WA

Oncogen - Seattle WA

C12N 1509

4351723

Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growth inhibitors for neoplastic cells without inhibiting normal cells or affect GABA-ergic transmission. The polypeptides find use in inhibiting neoplastic growth, modulating diazepam receptor response, and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the polypeptides.

4806492, Feb 21, 1989

Aug 15, 1985

6/766864

Mohammed Shoyab - Seattle WA
Hans Marquardt - Mercer Island WA
George J. Todaro - Seattle WA

Oncogen, Inc. - Seattle WA

G01N 3353
G01N 33534

436547

Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.

6171824, Jan 9, 2001

Nov 8, 1993

8/149101

George J. Todaro - Seattle WA
David W. Leung - Mercer Island WA
Timothy M. Rose - Seattle WA

Fred Hutchinson Cancer Research Center - Seattle WA

C12P 2106
C07H 1700
C07K 1400

435 695

Therapeutic hybrid cytokines, having a size ranging from about 10 to about 30 kDa, comprise portions of cytokines: leukemia inhibitory factor (LIF), granulocyte-colony stimulating factor (G-CSF), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin-M (OSM), and ciliaryneurotrophic factor (CNTF). Hybrid cytokines comprise three or four. alpha. -helical sequences selected from. alpha. -helical sequences of IL-6, G-CSF, LIF, IL-11, CNTF and OSM and linking sequences of 5-40 amino acids in length, selected from the linking sequences of IL-6, G-CSF, LIF, IL-11, CNTF and OSM or other, desirable linking sequences. In the hybrid cytokines, at least one. alpha. -helical sequence is derived from a different cytokine than at least one other. alpha. -helical sequence; or, at least one linking sequence of a cytokine differentiates the hybrid cytokine from a corresponding cytokine. In hybrid cytokines having three. alpha.

5077312, Dec 31, 1991

Oct 26, 1990

7/603520

Mohammed Shoyab - Seattle WA
George J. Todaro - Seattle WA

Oncogen - Seattle WA

A61K 31225

574547

Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon the source, the glycerides may be mono- or di-glycerides, wherein the total number of carbon atoms of the fatty acids is in the range of 18 to 26, so that the monoglyceride has a fatty acid of at least 18 carbon atoms, while the di-glyceride has a fatty acid of at least 14 carbon atoms.

5248666, Sep 28, 1993

Apr 29, 1992

7/877341

Daniel R. Twardzik - Bainbridge Island WA
George J. Todaro - Seattle WA

Oncogen - Seattle WA

A61K 3702

514 12

Novel polypeptide compositions are provided which inhibit human tumor cell growth, which may or may not stimulate autophosphorylation of pp6src and induce the release of a 52 kD polypeptide from neoplastic cells. Individual polypeptides may be isolated from mammalian blood platelets by selected extraction and purification procedures, may be synthesized or produced by hybrid DNA technology.

5925733, Jul 20, 1999

Jul 11, 1996

8/680326

Timothy M. Rose - Seattle WA
Marnix L. Bosch - Bellevue WA
Kurt Strand - Issaquah WA
George J. Todaro - Seattle WA

University of Washington - Seattle WA

A61K 3902
C07H 2104
C07K 100
C12N 900

530350

This invention provides isolated polynucleotides encoding DNA polymerases of three members of a subfamily of gamma herpes viruses. Two were obtained from macaque monkeys affected with retroperitoneal fibromatosis, the other from human AIDS patients affected with Kaposi's sarcoma. A 454-base pair fragment encoding a region near the active site of the DNA polymerase is 69-83% identical amongst the three viruses, but only 54-68% identical with other known gamma herpes sequences and

4816442, Mar 28, 1989

Nov 7, 1986

6/928760

John M. McPherson - Sunnyvale CA
Danile R. Twardzik - Bainbridge Island WA
George J. Todaro - Seattle WA
Karl A. Piez - Menlo Park CA
Jane E. Ranchalis - Seattle WA

Collagen Corporation - Palo Alto CA

A61K 3700

514 12

Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-. beta. activity, and anti-inflammatory activity have now been found to possess potent oncostatic activity. The CIFs showed oncostatic activity on human and animal tumors, including carcinomas, adenocarcinomas, lymphomas, and melanomas.