Inventors:
Pedro J. Beltran - Sherman Oaks CA, US
Frank J. Calzone - Westlake Village CA, US
Gregory Friberg - Westlake Village CA, US
Christopher Haqq - Newbury Park CA, US
Anthony W. Tolcher - San Antonio TX, US
International Classification:
A61K 39/395
A61K 38/00
A61K 31/7088
A61P 35/04
A61K 39/00
C12Q 1/68
C12Q 1/02
US Classification:
4241331, 4241581, 514 12, 514 44 A, 4241841, 435 6, 435 29
Abstract:
The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining whether a tumor is more or less likely to respond to such treatment, and compositions for practicing such methods. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.
