Han Cao resumes & CV records
Resumes
Han Cao
Han CaoBlawenburg, NJ
Han Cao Phones & Addresses
Blawenburg, NJ
Philadelphia, PA
Mentions for Han Cao
Publications & IP owners
Us Patents
Nanochannel Arrays And Their Preparation And Use For High Throughput Macromolecular Analysis
US Patent:
7670770, Mar 2, 2010
Filed:
Jul 25, 2002
Appl. No.:
10/484293
Inventors:
Stephen Y. Chou - Princeton NJ, US
Han Cao - Blawenburg NJ, US
Robert H. Austin - Princeton NJ, US
Zhaoning Yu - Princeton NJ, US
Jonas O. Tegenfeldt - Princeton NJ, US
Han Cao - Blawenburg NJ, US
Robert H. Austin - Princeton NJ, US
Zhaoning Yu - Princeton NJ, US
Jonas O. Tegenfeldt - Princeton NJ, US
Assignee:
The Trustees of Princeton University - Princeton NJ
International Classification:
C12Q 1/68
C12M 1/36
C07H 21/04
C12M 1/36
C07H 21/04
US Classification:
435 6, 4352831, 4352872, 4352882, 4352885, 422 681, 422 8205, 536 231, 977704, 977880, 977883
Abstract:
Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.
Gradient Structures Interfacing Microfluidics And Nanofluidics
US Patent:
8333934, Dec 18, 2012
Filed:
Sep 28, 2006
Appl. No.:
11/536178
Inventors:
Han Cao - Blawenburg NJ, US
Jonas O. Tegenfeldt - Lund, SE
Stephen Chou - Princeton NJ, US
Robert H. Austin - Princeton NJ, US
Jonas O. Tegenfeldt - Lund, SE
Stephen Chou - Princeton NJ, US
Robert H. Austin - Princeton NJ, US
Assignee:
Princeton University - Princeton NJ
International Classification:
G01N 21/00
G01N 21/75
G01N 33/00
B01L 3/00
G01N 21/75
G01N 33/00
B01L 3/00
US Classification:
422502, 422 63, 422 93, 422414
Abstract:
The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.
Methods And Devices For Single-Molecule Whole Genome Analysis
US Patent:
8628919, Jan 14, 2014
Filed:
Jun 30, 2009
Appl. No.:
13/001697
Inventors:
Ming Xiao - Huntingdon Valley PA, US
Parikshit A. Deshpande - Princeton NJ, US
Han Cao - Philadelphia PA, US
Michael Austin - Philadelphia PA, US
Kandaswamy Vijayan - San Diego CA, US
Alexey Y. Sharonov - Hamden CT, US
Michael Boyce-Jacino - Titusville NJ, US
Parikshit A. Deshpande - Princeton NJ, US
Han Cao - Philadelphia PA, US
Michael Austin - Philadelphia PA, US
Kandaswamy Vijayan - San Diego CA, US
Alexey Y. Sharonov - Hamden CT, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:
Bionano Genomics, Inc. - Philadelphia PA
International Classification:
C12Q 1/68
C12M 1/34
C12M 3/00
C07H 21/02
C12M 1/34
C12M 3/00
C07H 21/02
US Classification:
435 61, 435 611, 4352872, 536 231, 977704
Abstract:
Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e. g. , determining structural variations and copy number variations between individuals.
Gradient Structures Interfacing Microfluidics And Nanofluidics, Methods For Fabrication And Uses Thereof
US Patent:
2004003, Feb 19, 2004
Filed:
Apr 16, 2003
Appl. No.:
10/414620
Inventors:
Han Cao - Blawenburg NJ, US
Jonas Tegenfeldt - Rockyhill NJ, US
Stephen Chou - Princeton NJ, US
Robert Austin - Princeton NJ, US
Jonas Tegenfeldt - Rockyhill NJ, US
Stephen Chou - Princeton NJ, US
Robert Austin - Princeton NJ, US
International Classification:
C12Q001/68
C12M001/34
C12M003/00
G03F007/16
G03F007/20
G03F007/40
C23C014/34
G03B027/32
G03B027/52
G21G005/00
C12M001/34
C12M003/00
G03F007/16
G03F007/20
G03F007/40
C23C014/34
G03B027/32
G03B027/52
G21G005/00
US Classification:
435/006000, 435/287200, 430/320000, 430/296000, 430/323000, 430/324000, 204/192150, 355/027000, 250/492300, 204/298020
Abstract:
The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.
Methods Of Macromolecular Analysis Using Nanochannel Arrays
US Patent:
2008024, Oct 2, 2008
Filed:
Mar 28, 2008
Appl. No.:
12/057987
Inventors:
Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US
Parikshit A. Deshpande - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:
BIONANOMATRIX, LLC - Philadelphia PA
International Classification:
C40B 30/04
C40B 60/12
C40B 30/10
C40B 30/06
C40B 60/12
C40B 30/10
C40B 30/06
US Classification:
506 9, 506 39, 506 12, 506 10
Abstract:
Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
Nanonozzle Device Arrays: Their Preparation And Use For Macromolecular Analysis
US Patent:
2009030, Dec 10, 2009
Filed:
Jul 19, 2007
Appl. No.:
12/374141
Inventors:
Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US
Parikshit A. Deshpande - Princeton NJ, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:
BIONANOMATRIX, INC. - PHILADELPHIA PA
International Classification:
C12Q 1/68
C12M 1/34
C12M 1/34
US Classification:
435 6, 4352872
Abstract:
Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.
Nanochannel Arrays And Their Preparation And Use For High Throughput Macromolecular Analysis
US Patent:
2010002, Feb 4, 2010
Filed:
Oct 30, 2008
Appl. No.:
12/261406
Inventors:
Robert H. Austin - Princeton NJ, US
Zhaoning Yu - Princeton NJ, US
Jonas O. Tegenfeldt - Princeton NJ, US
Stephen Y. Chou - Princeton NJ, US
Han Cao - Philadelphia PA, US
Zhaoning Yu - Princeton NJ, US
Jonas O. Tegenfeldt - Princeton NJ, US
Stephen Y. Chou - Princeton NJ, US
Han Cao - Philadelphia PA, US
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY - Princeton NJ
International Classification:
C40B 40/06
C40B 40/00
C40B 50/14
C40B 60/12
C40B 30/00
C40B 40/00
C40B 50/14
C40B 60/12
C40B 30/00
US Classification:
506 16, 506 13, 506 30, 506 39, 506 7
Abstract:
Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.
Integrated Analysis Devices And Related Fabrication Methods And Analysis Techniques
US Patent:
2011029, Dec 8, 2011
Filed:
Jun 5, 2009
Appl. No.:
12/996410
Inventors:
Han Cao - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Mark Kunkel - Lawrenceville NJ, US
Alexey Y. Sharonov - Hamden CT, US
Michael Kochersperger - Princeton NJ, US
Michael D. Austin - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Mark Kunkel - Lawrenceville NJ, US
Alexey Y. Sharonov - Hamden CT, US
Michael Kochersperger - Princeton NJ, US
Assignee:
Bionanomatrix, Inc. - Philadelphai PA
International Classification:
G01N 1/16
B32B 37/16
B23P 17/00
G01N 21/64
B32B 37/02
B82Y 15/00
B32B 37/16
B23P 17/00
G01N 21/64
B32B 37/02
B82Y 15/00
US Classification:
73 6456, 2504591, 156292, 29423, 977902, 977781
Abstract:
Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
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