Chong Suk Han, 64San Jose, CA

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Polymorphs And Solid Forms Of (S)-2-((2-((S)-4-(Difluoromethyl)-2-Oxooxazolidin-3-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)Amino)Propanamide, And Methods Of Production

US Patent:

2020039, Dec 24, 2020

Filed:

May 15, 2020

Appl. No.:

16/875537

Inventors:

- South San Francisco CA, US
Chong Han - Foster City CA, US
Sean M. Kelly - South San Francisco CA, US
Karthik Nagapudi - South San Francisco CA, US
Scott Savage - Burlingame CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07D 498/04
A61P 35/00
A61P 35/02
A61P 35/04

Abstract:

The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I:

Polymorphs And Solid Forms Of (S)-2-((2-((S)-4-(Difluoromethyl)-2-Oxooxazolidin-3-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)Amino)Propanamide, And Methods Of Production

US Patent:

2018033, Nov 29, 2018

Filed:

Apr 26, 2018

Appl. No.:

15/963876

Inventors:

- South San Francisco CA, US
Chong Han - Foster City CA, US
Sean M. Kelly - South San Francisco CA, US
Karthik Nagapudi - South San Francisco CA, US
Scott Savage - Burlingame CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07D 498/04
A61P 35/02
A61P 35/04

Abstract:

The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I:

Process For Making Tricyclic Lactam Compounds

US Patent:

2017031, Nov 2, 2017

Filed:

Jul 18, 2017

Appl. No.:

15/652776

Inventors:

- South San Francisco CA, US
Haiming Zhang - San Mateo CA, US
Chong Han - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07D 471/14

Abstract:

Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).

Process For The Preparation Of (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1H-Indazol-5-Yl)But-1-En-1-Yl)Phenyl)Acrylic Acid

US Patent:

2017010, Apr 13, 2017

Filed:

Oct 6, 2016

Appl. No.:

15/287023

Inventors:

- South San Francisco CA, US
Serena Maria Fantasia - Basel, CH
Francis Gosselin - San Mateo CA, US
Chong Han - Foster City CA, US
Stefan Hildbrand - Basel, CH
Theresa Humphries - San Francisco CA, US
Christian Jenny - Basel, CH
Andrew McClory - South San Francisco CA, US
Christian Moessner - Basel, CH
Pankaj Rege - Basel, CH
Scott Savage - Burlingame CA, US
Haiming Zhang - San Mateo CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07D 231/56
C07C 309/73
C07C 69/73
C07F 5/04
C07D 405/04

Abstract:

Processes are described for the preparation of estrogen receptor modulating compound, (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid I:

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