Harry S Soroff, 9825 Asharoken Ave, Northport, NY 11768

6770024, Aug 3, 2004

Mar 28, 2000

09/536789

Jahangir S. Rastegar - New York City NY
Harry Soroff - New York City NY

Stony Brook Surgical Innovations, Inc. - Northport NY

A61B 1362

600 16, 623 311, 623 316, 623 321

A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself. In the event of mechanical failure, pre-implantation heart function is not impeded.

6770041, Aug 3, 2004

Apr 29, 2002

10/135032

Jahangir S. Rastegar - Stony Brook NY
Harry Soroff - Northport NY

P.P.T.T. L.L.P - Northport NY

A61H 3100

601 44, 601152

An applicator for applying an external counterpulsation to a body portion is provided. The applicator including: an outer shell for covering the body portion, the outer shell having a length in a longitudinal direction and a circumference in a circumferential direction; a balloon disposed in the outer shell, pressurization of which applies an external pressure to the body portion; and at least one anti-deformation member for reducing an amount of deformation of the outer shell caused by the pressurization of the balloon.

6846294, Jan 25, 2005

May 10, 2001

09/851930

Jahangir Rastegar - Stony Brook NY, US
Harry S. Soroff - Northport NY, US

PPT LLC - Sands Point NY

A61H 900
A61H 2300

601 9, 601 11, 601 44, 601152

The cardiac assist device includes a sealed tubular housing for externally applying positive and negative relative pressure to a limb in counterpulsation with heart function. The applicator is assembled, in situ, to provide customized fit. It includes a fabric or sponge-like inner layer cut to size and situated around the limb. Initially deformable material is sized, sealed around the inner fabric layer and then secured by straps or the like to form a relatively rigid, non-expandable tubular shell. The shell may include an interior wall composed of a sheet of hard plastic or articulated sections of hard plastic or metal. The interior wall has a plurality of openings to the sealed shell interior. The exterior shell wall is positioned around the interior wall. The shell walls are spaced apart by radially and/or longitudinally extending spacer elements defining a multi-section air flow chamber between the walls.

6948501, Sep 27, 2005

Apr 29, 2002

10/135063

Jahangir S. Rastegar - Stony Brook NY, US
Harry Soroff - Northport NY, US

P.P.T.T. L.L.P. - Northport NY

A61G015/00
A61F013/00
A61B019/00
A61B005/37

128845, 128846, 128869, 128870, 606242, 601152

A patient support for an external counterpulsation cardiac assist procedure. The patient support includes: a base; and at least one support connected to the base for maintaining at least a portion of the patient above a tabletop during a positive pressure portion of the external counterpulsation cardiac assist procedure. In one embodiment, the base is a tabletop and the at least one support is movably supported on the table top in lateral and/or vertical directions. In another embodiment, the base is higher than the tabletop and the at least one support is a sling.

7481760, Jan 27, 2009

Jun 22, 2004

10/873824

Jahangir S. Rastegar - Stony Brook NY, US
Harry Soroff - Northport NY, US

PPTT LLC - Sands Point NY

A61M 1/12

600 16, 623 31

A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself. In the event of mechanical failure, pre-implantation heart function is not impeded.

7641900, Jan 5, 2010

Mar 30, 2005

11/093540

Harry Soroff - Northport NY, US
Marcia Simon - Stony Brook NY, US
Thomas Fallon - Saratoga Springs NY, US
Peter Fallon - Loudonville NY, US
Gabriele Hatch - Setauket NY, US

Research Foundation of State University of New York - Albany NY

A61K 38/46
A61K 38/48
A61K 38/54
A01N 37/18

424 9467, 424 9463, 424 941, 514 2

The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e. g. , burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphatidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.

8142372, Mar 27, 2012

May 23, 2007

11/805421

Jahangir Rastegar - Stony Brook NY, US
Harry Soroff - Northport NY, US

A61H 7/00
A61H 9/00

601 9, 601 11, 601 44, 601152

The invention provides a treatment for congestive heart failure (CHF) in a patient. At least one pressure applicator is arranged externally around a body segment of the patient. Negative pressure, relative to atmospheric pressure, is applied to the body segment of the patient during cardiac systole using the pressure applicator, thereby reducing ventricular afterload in the patient. The negative pressure to the body segment of the patient is removed during cardiac diastole.

8286656, Oct 16, 2012

Dec 24, 2008

12/317512

Jahangir S. Rastegar - Stony Brook NY, US
Harry Soroff - Northport NY, US

PPTT LLC - Sands Point NY

F16K 51/00

137 1518, 137849, 137847, 251 5, 623 219

A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself. In the event of mechanical failure, pre-implantation heart function is not impeded.