Heather C Maynard, 39Glendora, CA

6376690, Apr 23, 2002

Aug 30, 1999

09/386205

Robert H. Grubbs - Pasadena CA
Heather D. Maynard - Pasadena CA
David M. Lynn - Somerville MA

California Institute O Technology - Pasadena CA

C07F 1500

556 21, 556136

The present invention generally relates to the discovery that the solubility of metal complexes may be readily manipulated by the addition of one or more solubility-enhancing compounds. This manipulation of the solubilities allows for the preparation of suitable samples for precise quantitative analysis and for the facile purification of the desired products from the reaction mixture containing one or more metal complexes. In one embodiment of the invention, the relative solubilities between two solutions are manipulated so as cause the metal complex found in a first solution to transfer to a second solution that is generally immiscible with the first solution. The metal complex is thus separated from the reaction mixture which comprises the first solution by the removal of the second solution. In another embodiment, the solubility-enhancing compounds of the present invention is used to prepare samples containing metal complexes for precise quantitative analysis such as inductively coupled plasma mass spectroscopy.

6482908, Nov 19, 2002

May 5, 2000

09/567569

Robert H. Grubbs - South Pasadena CA
Michael J. Marsella - Riverside CA
Heather D. Maynard - Sierra Madre CA

California Institute of Technology - Pasadena CA

C08F 444

526171, 526172, 526173, 558381, 502155, 502167

Functionalized cyclic olefins and methods for making the same are disclosed. Methods include template-directed ring-closing metathesis (âRCMâ) of functionalized acyclic dienes and template-directed depolymerization of functionalized polymers possessing regularly spaced sties of unsaturation. Although the template species may be any anion, cation, or dipolar compound, cationic species, especially alkali metals, are preferred. Functionalized polymers with regularly spaced sites of unsaturation and methods for making the same are also disclosed. One method for synthesizing these polymers is by ring-opening metathesis polymerization (âROMPâ) of functionalized cyclic olefins. The metathesis catalysts for both RCM and ROMP reaction are ruthenium or osmium carbene complex catalysts of the formula where M is Os or Ru; R and R each may be hydrogen C -C alkenyl, C -C alkynyl, C -C alkyl, aryl, C -C carboxylate, C -C alkoxy, C -C alkenyloxy, C -C alkynyloxy, aryloxy, C -C alkoxycarbonyl, C -C alkylthio, C -C alkylsulfonyl or C -C alkylsulfinyl; X and X may be any anionic ligand; and L and L may be any neutral electron donor.

7060681, Jun 13, 2006

Jul 22, 2002

10/201547

Jeffrey A. Hubbell - Zurich, CH
Ronald Schoenmakers - Zurich, CH
Heather D. Maynard - Santa Monica CA, US

Ecole Polytechnique Federale de Lausanne (EPFL) - Lausanne

A61K 38/00

514 12, 530300

The application describes ligands for binding targets, the ligands preferably including peptides having at least one sulfated or sulfonated amino acid. The ligand preferably specifically binds to heparin binding sites of biomolecules. Compositions, systems, and methods for making and using the ligands are described.

7786213, Aug 31, 2010

Feb 2, 2007

10/576038

Heather D. Maynard - Los Angeles CA, US
Debora Bontempo - Mainz, DE

The Regents Of The University Of California - Oakland CA

A61K 47/48
A61K 9/16
C08L 89/00
C08B 37/00

525 541, 527201, 527202

Chemical polymerization procedures initiated by, and proceeding from, a biomolecule, particularly a protein, for the formation of biomolecule-polymer conjugates, particularly protein-polymer conjugates, which have therapeutic uses, are intermediates for forming other materials or are usable in diagnostic sensors are disclosed. Polymerization can be initiated by a protein in the absence of additional initiation agents to form the protein-polymer conjugate. Alternatively, polymerization is initiated in the presence of an additional initiation agent that does not interact with the protein. Amino acids existing in the protein can serve as the sites for initiation of the polymerization or the protein can be modified to contain site(s) for initiation or protein with active sites can be prepared by recombinant methods, chemical ligation, solid-phase synthesis, or other techniques to generate site(s) for initiation.

6080826, Jun 27, 2000

Dec 18, 1997

8/993757

Robert H. Grubbs - South Pasadena CA
Michael J. Marsella - Riverside CA
Heather D. Maynard - Sierra Madre CA

California Institute of Technology - Pasadena CA

C08F 200
C07C 202

526 75

Functionalized cyclic olefins and methods for making the same are disclosed. Methods include template-directed ring-closing metathesis ("RCM") of functionalized acyclic dienes and template-directed depolymerization of functionalized polymers possessing regularly spaced sites of unsaturation. Although the template species may be any anion, cation, or dipolar compound, cationic species, especially alkali metals, are preferred. Functionalized polymers with regularly spaced sites of unsaturation and methods for making the same are also disclosed. One method for synthesizing these polymers is by ring-opening metathesis polymerization ("ROMP") of functionalized cyclic olefins. The metathesis catalysts for both RCM and ROMP reaction are ruthenium or osmium carbene complex catalysts of the formula ##STR1## where M is Os or Ru; R and R. sup. 1 each may be hydrogen, C. sub. 2 -C. sub. 20 alkenyl, C. sub. 2 -C. sub.

2018031, Nov 1, 2018

Aug 13, 2015

15/503350

- Oakland CA, US
Heather D. Maynard - Los Angeles CA, US

C08G 63/91
A61K 47/34
A61K 38/19
C08G 63/08
C08G 63/688

Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R[RRC—CRR]n-[DG]-R, wherein R-Rare independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R-Ris a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein Rand Rare end groups.

2018011, Apr 26, 2018

Dec 29, 2016

15/394483

- Oakland CA, US
Heather D. Maynard - Los Angeles CA, US

C08G 63/91
C07H 3/04
C08G 63/78

Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R—[RRC—CRR]-[DG]—R, wherein R-Rare independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R-Ris a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein Rand Rare end groups.

2017024, Aug 24, 2017

Aug 12, 2015

15/503348

- Oakland CA, US
Heather D. Maynard - Los Angeles CA, US

C08J 3/075
A61K 38/28
A23K 20/163
C12N 9/16
A61K 47/32
A61K 9/06
C12N 9/96

Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.