Hiroshi Abe, 6129 Tulip Tree Ln, Mamaroneck, NY 10543

7745614, Jun 29, 2010

Sep 1, 2005

11/218961

Eric Todd Kool - Stanford CA, US
Hiroshi Abe - Mountain View CA, US

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

C07H 21/02
C07H 19/04
C12Q 1/68
C07H 21/00
C07F 9/00

536 266, 536 41, 536 231, 536 253, 536 2332, 532 1, 564 12, 977792, 435 6

A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.

5223547, Jun 29, 1993

Nov 25, 1991

7/797350

Shoichiro Harada - Wakayama, JP
Yasutoshi Isayama - Wakayama, JP
Tetsuaki Fukushima - Wakayama, JP
Masayoshi Morii - Wakayama, JP
Hiroshi Kitagawa - Wakayama, JP
Hiroshi Abe - Albany CA

KAO Corporation - Tokyo

C08G 1814

521 78

Processes for producing a polyurethane, a rigid polyurethane foam, a flexible polyurethane foam and a spray type rigid polyurethane foam are disclosed. In these processes, a specified tertiary aminoalcohol is used as a polyol component and a catalyst.

5296631, Mar 22, 1994

Apr 21, 1992

7/871541

Hiroshi Abe - Albany CA
Hideki Taniguchi - Wakayama, JP
Yoshifumi Nishimoto - Wakayama, JP
Kohshiro Sotoya - Wakayama, JP

Kao Corporation - Tokyo

C07C20916

564480

A process for producing an N-alkyl-N-methylamine or an N-alkenyl-N-methylamine in a high yield from a higher alcohol and methylamine comprising the step of reacting a higher alcohol with methylamine in the presence of a catalyst comprising copper and a fourth period transition metal of the Periodic Table, except for chromium, or a catalyst comprising copper, a fourth period transition metal of the Periodic Table, except for chromium, and an element of the platinum group VIII of the Periodic Table, at a pressure ranging from atmospheric pressure to 100 atm. G. , at a reaction temperature ranging from 100. degree. to 250. degree. C. , with hydrogen gas being introduced into the reaction system while water produced in the reaction is removed from the reaction system and the amount of methylamine in the gaseous mixture which contains no matter formed through the reaction and is exhausted from the reaction system is regulated from 5 to 50% by volume.

5444099, Aug 22, 1995

Sep 20, 1993

8/123165

Hiroshi Abe - Albany CA
Tetsuaki Fukushima - Wakayama, JP
Kohshiro Sotoya - Wakayama, JP
Shoichiro Harada - Wakayama, JP
Hiroshi Kitagawa - Wakayama, JP
Masayoshi Morii - Ibaraki, JP
Yasutoshi Isayama - Wakayama, JP

Kao Corporation - Tokyo

C07C21502
C08G 1814

521129

A tertiary aminoalcohol having a tert-amino group(s) in the main chain and hydroxyl groups at the terminals. The use of this compound for purposes different from that of ordinary amines and amine derivatives is expected. A process for producing the tertiary aminoalcohol wherein a catalyst comprising copper, a transition metal element of the fourth period and a platinum group element of the group VIII, and further optionally containing an alkali metal or an alkaline earth metal is used. A process for producing polyurethane using the above-mentioned tertiary aminoalcohol which can solve the problems occurring in the production of a polyurethane using a tertiary amine which has a strong irritating odor and is highly irritant to the skin as a catalyst, for example, deteriorations of working atmosphere and sales appeal of the polyurethane. The chemical structure of the above-described tertiary aminoalcohol is as follows: ##STR1##.

5315041, May 24, 1994

Mar 4, 1992

7/845594

Hiroshi Abe - Albany CA
Tetsuaki Fukushima - Wakayama, JP
Kohshiro Sotoya - Wakayama, JP
Shoichiro Harada - Wakayama, JP
Hiroshi Kitagawa - Wakayama, JP
Masayoshi Morii - Ibaraki, JP
Yasutoshi Isayama - Wakayama, JP

Kao Corporation - Tokyo

C07C21502

564506

A tertiary aminoalcohol having a tert-amino group(s) in the main chain and hydroxyl groups at the terminals. The use of this compound for purposes different from that of ordinary amines and amine derivatives is expected. A process for producing the tertiary aminoalcohol wherein a catalyst comprising copper, a transition metal element of the fourth period and a platinum group element of the group VIII, and further optionally containing an alkali metal or an alkaline earth metal is used. A process for producing polyurethane using the above-mentioned tertiary aminoalcohol which can solve the problems occurring in the production of a polyurethane using a tertiary amine which has a strong irritating odor and is highly irritant to the skin as a catalyst, for example, deteriorations of working atmosphere and sales appeal of the polyurethane. The chemical structure of the above-described tertiary aminoalcohol is as follows: ##STR1##.