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Hong Z Liang1047 Stockton St, San Francisco, CA 94108

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Cui Liang

Hong Liang Phones & Addresses

1047 Stockton St, San Francisco, CA 94108    415-7730299   

666 Jackson St, San Francisco, CA 94133    415-7730299    415-9864368   

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Career records & work history

Medicine Doctors

Hong Liang

Specialties:
Internal Medicine
Work:
Hong Liang MD
3105 Del Mar Ave, Rosemead, CA 91770
626-2808897 (phone) 626-2809902 (fax)
Education:
Medical School
Nanjing Coll of Trad Chinese Med, Nanjing, Jiangsu, China
Graduated: 1984
Conditions:
Acne, Acute Bronchitis, Acute Pharyngitis, Atherosclerosis, Atopic Dermatitis, Atrial Fibrillation and Atrial Flutter, Benign Prostatic Hypertrophy, Chronic Bronchitis, Depressive Disorders, Diabetes Mellitus (DM), Fractures, Dislocations, Derangement, and Sprains, Gastroesophageal Reflux Disease (GERD), Gingival and Periodontal Diseases, Hypertension (HTN), Hypothyroidism, Infectious Liver Disease, Insomnia, Osteoarthritis, Peripheral Nerve Disorders, Substance Abuse and/or Dependency, Abnormal Vaginal Bleeding, Acute Conjunctivitis, Acute Sinusitis, Acute Upper Respiratory Tract Infections, Alopecia Areata, Alzheimer's Disease, Anemia, Angina Pectoris, Anorexia Nervosa, Anxiety Phobic Disorders, Benign Polyps of the Colon, Bipolar Disorder, Bronchial Asthma, Calculus of the Urinary System, Candidiasis of Vulva and Vagina, Cardiac Arrhythmia, Cardiomyopathy, Cholelethiasis or Cholecystitis, Chronic Renal Disease, Cirrhosis, Constipation, Contact Dermatitis, Dermatitis, Diabetic Peripheral Neuropathy, Disorders of Lipoid Metabolism, Erectile Dysfunction (ED), Gastritis and Duodenitis, Gastrointestinal Hemorrhage, Glaucoma, Gout, Heart Failure, Hemorrhoids, Herpes Genitalis, Herpes Zoster, Hyperthyroidism, Inflammatory Bowel Disease (IBD), Intervertebral Disc Degeneration, Irritable Bowel Syndrome (IBS), Ischemic Heart Disease, Lateral Epicondylitis, Malignant Neoplasm of Female Breast, Menopausal and Postmenopausal Disorders, Myasthenia Gravis (MG), Nephrotic Syndrome, Osteoporosis, Parkinson's Disease, Plantar Warts, Pneumonia, Premenstrual Syndrome (PMS), Rheumatoid Arthritis, Sciatica, Sexually Transmitted Diseases (STDs), Skin and Subcutaneous Infections, Skin Cancer, Tempromandibular Joint Disorders (TMJ), Tinea Pedis, Tinea Unguium, Varicose Veins, Venous Embolism and Thrombosis, Vitamin D Deficiency
Languages:
Chinese, English, Vietnamese
Description:
Dr. Liang graduated from the Nanjing Coll of Trad Chinese Med, Nanjing, Jiangsu, China in 1984. He works in Rosemead, CA and specializes in Internal Medicine. Dr. Liang is affiliated with Alhambra Hospital Medical Center, Garfield Medical Center and San Gabriel Valley Medical Center.

Publications & IP owners

Us Patents

Isolated Antibody Which Specifically Binds To Pcsk9

US Patent:
8080243, Dec 20, 2011
Filed:
Sep 11, 2009
Appl. No.:
12/558312
Inventors:
Hong Liang - San Francisco CA, US
Yasmina Noubia Abdiche - Mountain View CA, US
Javier Fernando Chaparro Riggers - San Mateo CA, US
Bruce Charles Gomes - Ashburnham MA, US
Julie Jia Li Hawkins - Old Lyme CT, US
Jaume Pons - San Bruno CA, US
Yuli Wang - San Diego CA, US
Assignee:
Rinat Neuroscience Corp. - South San Francisco CA
Pfizer Inc. - New York NY
International Classification:
A61K 39/395
US Classification:
4241301, 4241331
Abstract:
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

Isolated Nucleic Acid Encoding An Antibody Which Specifically Binds To Pcsk9 And A Host Cell That Produces The Antibody

US Patent:
8399646, Mar 19, 2013
Filed:
Sep 2, 2011
Appl. No.:
13/225119
Inventors:
Hong Liang - San Francisco CA, US
Yasmina Noubia Abdiche - Mountain View CA, US
Javier Fernando Chaparro Riggers - San Mateo CA, US
Bruce Charles Gomes - Ashburnham MA, US
Julie Jia Li Hawkins - Old Lyme CT, US
Jaume Pons - San Bruno CA, US
Yuli Wang - San Diego CA, US
Assignee:
Rinat Neuroscience Corp. - South San Francisco CA
Pfizer Inc. - New York NY
International Classification:
C07H 21/04
C12P 21/08
C12N 5/07
US Classification:
536 2353, 435 691, 435326, 435329
Abstract:
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

Method For Reducing A Level Of Ldl-Cholesterol By An Antibody That Specifically Binds To Pcsk9

US Patent:
8426363, Apr 23, 2013
Filed:
Sep 2, 2011
Appl. No.:
13/225265
Inventors:
Hong Liang - San Francisco CA, US
Yasmina Noubia Abdiche - Mountain View CA, US
Javier Fernando Chaparro Riggers - San Mateo CA, US
Bruce Charles Gomes - Ashburnham MA, US
Julie Jia Li Hawkins - Old Lyme CT, US
Jaume Pons - San Bruno CA, US
Yuli Wang - San Diego CA, US
Assignee:
Rinat Neuroscience Corp. - South San Francisco CA
Pfizer Inc. - New York NY
International Classification:
A61P 3/06
A61K 38/00
US Classification:
514 74, 4241301, 4241311
Abstract:
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

Antibodies With Ph Dependent Antigen Binding

US Patent:
2011022, Sep 22, 2011
Filed:
Mar 10, 2011
Appl. No.:
13/045345
Inventors:
Jaume Pons - San Bruno CA, US
Jeffrey Raymond Chabot - Medford MA, US
Javier Fernando Chaparro Riggers - San Mateo CA, US
Bruce Charles Gomes - Ashburnham MA, US
Hong Liang - San Francisco CA, US
Kapil Mayawala - Peabody MA, US
Arvind Rajpal - San Francisco CA, US
David Louis Shelton - Oakland CA, US
International Classification:
A61K 39/395
C07K 16/00
C07K 16/40
C07K 16/42
C07K 16/18
C07H 21/04
A61P 3/06
C40B 40/10
C12N 5/10
C12N 1/00
US Classification:
4241581, 5303871, 5303917, 5303891, 5303872, 5303892, 4241301, 5303873, 536 2353, 506 18, 435325, 435243
Abstract:
The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the Kor kratio at pH 5.5/pH 7.4 or at pH 6.0/pH 7.4 is more than, or ranges between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH dependent antibodies preferentially dissociate from the antigen in the endosome. This can increase antibody half life, as compared to antibodies with equivalent Ks at pH 7.4 but with no pH dependent binding, when the antigen is one that undergoes antigen-mediated clearance (e.g., PCSK9). Antibodies with pH dependent binding can decrease total antigen half life when the antigen undergoes reduced clearance when bound to antibody (e.g., IL6). Antibodies with pH dependent binding can also prolong the decrease in antigen which is not antibody-bound. This can be important when antagonizing a target antigen typically present at high levels (e.g., IgE, DKK1, C5 and SOST). In addition, such antibodies can increase antigen half life when the antigen is a receptor and the receptor has increased clearance when bound to antibody (e.g, GMCSF receptor).

Antibodies And Conjugates Thereof

US Patent:
2021032, Oct 21, 2021
Filed:
Apr 8, 2021
Appl. No.:
17/301599
Inventors:
- Palo Alto CA, US
Wah Yuen To - San Mateo CA, US
Hong Liang - Hillsborough CA, US
International Classification:
C07K 16/22
A61K 47/58
A61K 47/68
Abstract:
Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof. Some embodiments of the antibodies can be conjugated to a moiety, such as a HEMA-PC polymer. Some embodiments of the antibody conjugates can retain or enhance antibody activity. The antibody and conjugate thereof can be particularly useful for treating diabetic retinopathy. Further provided are methods for conjugation of a polymer to a protein such as an antibody, such as IgG1.

Methods Of Treating An Eye Disorder

US Patent:
2021010, Apr 15, 2021
Filed:
Oct 9, 2020
Appl. No.:
17/066856
Inventors:
- Palo Alto CA, US
Joel Naor - Palo Alto CA, US
Hong Liang - Palo Alto CA, US
International Classification:
C07K 17/08
A61K 9/00
A61K 47/58
A61K 47/68
A61P 27/02
Abstract:
Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and/or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate that includes a polymeric moiety that extends the half-life/effectiveness/properties of the antibody when administered to a subject. A method of the present disclosure includes administering one or more doses of an anti-VEGF antibody conjugate to a subject (e.g., human or other mammalian patient) in need of treating an eye disorder, where the anti-VEGF antibody conjugate may be administered less frequently than a standard anti-VEGF therapy to treat the eye disorder.

Antibodies With Ph Dependent Antigen Binding

US Patent:
2020002, Jan 23, 2020
Filed:
Mar 8, 2019
Appl. No.:
16/296852
Inventors:
- New York NY, US
- South San Francisco CA, US
Javier Fernando CHAPARRO RIGGERS - San Mateo CA, US
Bruce Charles GOMES - Ashburnham MA, US
Hong LIANG - Hillsborough CA, US
KapiI MAYAWALA - New Brunswick NJ, US
Arvind RAJPAL - San Francisco CA, US
David Louis SHELTON - Oakland CA, US
International Classification:
C07K 16/42
C07K 16/40
C07K 16/28
Abstract:
The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the Kor kratio at pH 5.5/pH 7.4 or at pH 6.0/pH 7.4 is more than, or ranges between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH dependent antibodies preferentially dissociate from the antigen in the endosome. This can increase antibody half life, as compared to antibodies with equivalent Ks at pH 7.4 but with no pH dependent binding, when the antigen is one that undergoes antigen-mediated clearance (e.g., PCSK9). Antibodies with pH dependent binding can decrease total antigen half life when the antigen undergoes reduced clearance when bound to antibody (e.g., IL6). Antibodies with pH dependent binding can also prolong the decrease in antigen which is not antibody-bound. This can be important when antagonizing a target antigen typically present at high levels (e.g., IgE, DKK1, C5 and SOST). In addition, such antibodies can increase antigen half life when the antigen is a receptor and the receptor has increased clearance when bound to antibody (e.g., GMCSF receptor).

Il-6 Antibodies And Fusion Constructs And Conjugates Thereof

US Patent:
2019027, Sep 5, 2019
Filed:
Mar 1, 2019
Appl. No.:
16/290128
Inventors:
- PALO ALTO CA, US
Fernando Corrêa - Hayward CA, US
Hong Liang - Hillsborough CA, US
D. Victor Perlroth - Palo Alto CA, US
International Classification:
C07K 16/24
A61K 47/68
A61K 47/60
A61P 27/02
A61P 3/10
A61K 9/00
A61K 9/08
Abstract:
The present invention provides antagonizing antibodies that bind to IL-6, fusion proteins thereof with VEGF Trap, and conjugates of either thereof, and methods of using same. The anti-IL-6 antibodies can be used therapeutically alone or in combination with other therapeutics to diseases.

Amazon

Hong Liang Photo 44

The Black Book Of Clinical Examination

Author:
Dr Tey Hong Liang, Dr Erle Lim
Publisher:
McGraw-Hill Education (Asia)
Binding:
Paperback
Pages:
408
ISBN #:
0071268367
EAN Code:
9780071268363
OVERVIEW This book takes the medical student through the steps of a basic clinical examination. The authors, who have many years of experience coaching candidates for undergraduate and postgraduate examinations, stress the significance of important steps and relevant signs, highlight common errors, ...
Hong Liang Photo 45

New Hsk Test Scouring Hsk (3 Levels) ( 2013 Latest Version ) ( Set Of 2 ) ( With Mp3 Cd 1 )(Chinese Edition)

Author:
LIANG HONG YAN
Publisher:
Beijing Language and Culture University Press
Binding:
Paperback
ISBN #:
7561934424
EAN Code:
9787561934425
Hong Liang Photo 46

Intensive Training Of The New Hsk Level 6 (New Edition) (Chinese Edition)

Author:
liang hong yan
Publisher:
Beijing Language and Culture University Press
Binding:
Paperback
Pages:
299
ISBN #:
7561929293
EAN Code:
9787561929292
This book includes eight model tests, listenning scripts, key answers and answering strategies.The type of question, language material, passage length and difficulty of tests are in complete accordance with the general requirments of the outline of the new HSK.These tests cover all test points requi...
Hong Liang Photo 47

Tutorial Of Sketch (Chinese Edition)

Author:
zhang hong liang
Publisher:
China Electric Power Press
Binding:
Paperback
Pages:
129
ISBN #:
7512307268
EAN Code:
9787512307261
This book is compiled in accordance with the requirements of the sketch courses of the major- fine art and artistic design for institutions of higher learning. This book is divided into 6 chapters, which introduce in simple language, step by step, the basic theory, tools and expression skills of ske...
Hong Liang Photo 48

Surface Modification And Mechanisms: Friction, Stress, And Reaction Engineering

Publisher:
CRC Press
Binding:
Hardcover
Pages:
800
ISBN #:
0849338069
EAN Code:
9780849338069
Leading readers through an extensive compilation of surface modification reactions and processes for specific tribological results, this reference compiles detailed studies on various residual stresses, reaction processes and mechanisms, heat treatment methods, plasma-based techniques, and more, for...
Hong Liang Photo 49

Hong Kong Sar: Meeting The Challenges Of Integration With The Mainland (Occasional Paper (Intl Monetary Fund))

Author:
William Lee, Jorge A. Chan-Lau, Dora M. Iakova, Papa M'B. P. N'Diaye, Tao Wang, Ida Liu, Hong Liang, Eswar Prasad
Publisher:
INTERNATIONAL MONETARY FUND
Binding:
Kindle Edition
Pages:
59
This Occasional Paper provides an overview of the main challenges facing Hong Kong SAR as it continues to become more closely integrated with the mainland of China. Section I provides an overview of recent macroeconomic developments and the main policy issues in Hong Kong SAR. Section II examines va...
Hong Liang Photo 50

An Intensive Guide To The New Hsk Test-Instruction And Practice Level 5 (Chinese Edition)

Author:
liang hong yan bian zhu
Publisher:
Beijing Language and Cculture University Press
Binding:
Paperback
Pages:
193
ISBN #:
7561930240
EAN Code:
9787561930243
Designed on the basis of the New HSK Chinese Proficiency Test Syllabus released by Hanban, this book includes 8 sets of simulated tests, listening materials, reference answers and problem-solving strategies, complying with the New HSK Syllabus in all aspe
Hong Liang Photo 51

Hong Liangs Regular Script Legal Maxim - The Classic Maxim Of The Laws Of The Famous Book Cong Posts (Chinese Edition)

Author:
Hong Liang
Publisher:
China Legal Publishing House
Binding:
Paperback
Pages:
21
ISBN #:
7509332923
EAN Code:
9787509332924
This book is written by calligrapher Hong Liang use the form of the running script, selection of legal maxims fifteen be written, is intended to be the law in the form of the art of calligraphy popularity, it is very creative.

Isbn (Books And Publications)

Tribology In Chemical-Mechanical Planarization

Author:
Hong Liang
ISBN #:
0824725670

Surface Modification And Mechanisms: Friction, Stress, And Reaction Engineering

Author:
Hong Liang
ISBN #:
0824748727

Mechanical Tribology: Materials, Characterization, And Applications

Author:
Hong Liang
ISBN #:
0824748735

Surface Modification And Mechanisms: Friction, Stress And Reaction Engineering

Author:
Hong Liang
ISBN #:
0824752686

Possible Relatives

David H Liang  Dan C Liang  Elsie Liang  Emily W Liang  Eric C Liang  Hongyu Liang  Janice H Liang  Hong K Jung  Hong K Kee  Hong Kim 

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