Hongmin H Zhang, 4710 Shepherd Ave, Boston, MA 02115
Hongmin Zhang Phones & Addresses
10 Shepherd Ave, Boston, MA 02115
1258 Commonwealth Ave, Allston, MA 02134 617-2320558
Mentions for Hongmin H Zhang
Publications & IP owners
Us Patents
Degradable Crosslinkers, And Degradable Crosslinked Hydrogels Comprising Them
US Patent:
6713646, Mar 30, 2004
Filed:
Jun 27, 2002
Appl. No.:
10/186251
Inventors:
Hongmin Zhang - Duxbury MA
Alexander Schwarz - Brookline MA
Alexander Schwarz - Brookline MA
Assignee:
Biosphere Medical - Rockland MA
International Classification:
C07C 6952
US Classification:
560205, 560312
Abstract:
One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.
Degradable Carbamate-Containing Bis(Acryloyl) Crosslinkers, And Degradable Crosslinked Hydrogels Comprising Them
US Patent:
6884905, Apr 26, 2005
Filed:
Feb 25, 2003
Appl. No.:
10/374508
Inventors:
Hongmin Zhang - Duxbury MA, US
Alexander Schwarz - Brookline MA, US
Alexander Schwarz - Brookline MA, US
Assignee:
Biosphere Medical - Rockland MA
International Classification:
C07C271/00
US Classification:
560158
Abstract:
One aspect of the present invention relates to base-labile, carbamate-containing crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile, carbamate-containing crosslinker. The present invention also relates to methods of preparing base-labile, carbamate-containing crosslinkers. Another aspect of the present invention relates to methods of preparing cross-linked polymers and hydrogels comprising a base-labile, carbamate-containing crosslinker.
Degradable Crosslinkers, And Degradable Crosslinked Hydrogels Comprising Them
US Patent:
7135593, Nov 14, 2006
Filed:
Mar 22, 2004
Appl. No.:
10/806036
Inventors:
Hongmin Zhang - Duxbury MA, US
Alexander Schwarz - Brookline MA, US
Alexander Schwarz - Brookline MA, US
Assignee:
Biosphere Medical, Inc. - Rockland MA
International Classification:
C07C 96/52
C07C 239/00
C08F 20/00
C07C 239/00
C08F 20/00
US Classification:
560205, 560312, 526328
Abstract:
One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.
Embolization Using Degradable Crosslinked Hydrogels
US Patent:
7838699, Nov 23, 2010
Filed:
Mar 14, 2003
Appl. No.:
10/389708
Inventors:
Alexander Schwarz - Brookline MA, US
Hongmin Zhang - Duxbury MA, US
Hongmin Zhang - Duxbury MA, US
Assignee:
Biosphere Medical - Rockland MA
International Classification:
C07C 69/52
C07C 239/00
C08F 20/00
A61F 13/00
C07C 239/00
C08F 20/00
A61F 13/00
US Classification:
560205, 560312, 526328, 424422
Abstract:
One aspect of the present invention relates to a method of temporarily embolizing a blood vessel using a hydrolytically degradable crosslinked hydrogel as an embolus. In certain embodiments, the hydrolytically degradable crosslinked hydrogel substantially hydrolyzes only at about physiological pH. In certain embodiments of the method, the hydrolytically degradable crosslinked hydrogel is stable at low pH. In certain embodiments of the method, the hydrolytically degradable crosslinked hydrogel comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound. It is to be understood that both the foregoing general description and the following detailed description are exemplary, and are intended to provide further explanation of the invention as claimed.
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