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Hui J Cen, 34881 Union St, San Francisco, CA 94133

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881 Union St, San Francisco, CA 94133    415-6743878   

Discovery Bay, CA   

Antioch, CA   

Mentions for Hui J Cen

Publications & IP owners

Us Patents

Egfh2 Genes And Gene Products

US Patent:
6825333, Nov 30, 2004
Filed:
Aug 15, 2000
Appl. No.:
09/640041
Inventors:
W. Michael Kavanaugh - Mill Valley CA
Hui Cen - Oakland CA
Pauline Lee - Novato CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C07H 2104
US Classification:
536 235, 435 691, 435 2523, 4353201, 435455
Abstract:
This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.

Antibodies To Egfh2 Polypeptides

US Patent:
7276587, Oct 2, 2007
Filed:
Aug 31, 2004
Appl. No.:
10/931285
Inventors:
W. Michael Kavanaugh - Mill Valley CA, US
Hui Cen - Oakland CA, US
Pauline Lee - Novato CA, US
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C07K 16/00
US Classification:
5303879
Abstract:
This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.

Egfh2 Genes And Gene Products

US Patent:
7705117, Apr 27, 2010
Filed:
Jan 22, 2007
Appl. No.:
11/656882
Inventors:
W. Michael Kavanaugh - Mill Valley CA, US
Hui Cen - Oakland CA, US
Pauline Lee - Novato CA, US
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
A61K 38/00
C07K 14/00
US Classification:
530300, 530350
Abstract:
This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.

Enzyme Substrate Comprising A Functional Dye And Associated Technology And Methods

US Patent:
8092784, Jan 10, 2012
Filed:
Nov 21, 2006
Appl. No.:
12/095322
Inventors:
Fei Mao - Fremont CA, US
Hui Cen - Oakland CA, US
Wai-yee Leung - San Ramon CA, US
Assignee:
Biotium, Inc. - Hayward CA
International Classification:
A61B 10/00
C12Q 1/68
US Classification:
424 96, 435 61, 435 611, 435 618, 435 74
Abstract:
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

Enzyme Substrate Comprising A Functional Dye And Associated Technology And Methods

US Patent:
8586325, Nov 19, 2013
Filed:
May 10, 2013
Appl. No.:
13/891406
Inventors:
Fei Mao - Fremont CA, US
Hui Cen - Oakland CA, US
Assignee:
Biotium, Inc. - Hayward CA
International Classification:
C12Q 1/37
A61K 38/14
C07D 279/08
US Classification:
435 23, 435 24, 435212, 435219, 530330, 548146, 548148, 548152
Abstract:
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

Human Fgf Gene And Gene Expression Products

US Patent:
2003011, Jun 19, 2003
Filed:
Apr 17, 2001
Appl. No.:
09/836960
Inventors:
Hui Cen - Alameda CA, US
Pablo Garcia - San Francisco CA, US
Uta Grieshammer - San Francisco CA, US
Altaf Kassam - Alameda CA, US
Pauline Lee - Contra Costa CA, US
David Pot - San Francisco CA, US
Denis Gospodarowicz - Contra Costa CA, US
Kathleen Martin - Alameda CA, US
International Classification:
C07H021/04
C12N001/18
C12N001/21
C12N005/06
C12P021/02
C07K014/50
US Classification:
435/069400, 435/325000, 435/252300, 435/254100, 536/023500, 530/399000
Abstract:
This invention relates to human fibroblast growth factor (FGF 98), and to variants thereof and to polynucleotides encoding FGF 98. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies.

Method Of Screening For Factors That Modulate Gene Expression

US Patent:
2003017, Sep 11, 2003
Filed:
Jun 18, 2002
Appl. No.:
10/174152
Inventors:
Hui Cen - Oakland CA, US
Jaime Escobedo - Alamo CA, US
Lewis Williams - Tiburon CA, US
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12Q001/68
G01N033/53
G01N033/567
US Classification:
435/006000, 435/007200
Abstract:
The invention describes a method of screening for factors that modulate gene expression, by detection of factors including factors that stimulate or inhibit cell growth, differentiation or proliferation, factors involved in one or more signal transduction pathways, or factors involved in protein-protein interactions. Identification of such factors that modulate gene expression is accomplished by detection of an intracellular event mediated by the factor. The intracellular event can be an increase or decrease in transcription or translational activities. Detection of the intracellular event is accomplished by any highly sensitive assay targeting a transcription or translation product, including, for example, a bDNA assay to the nascent transcript induced by the factor.

Method Of Selective Protein Enrichment And Associated Applications

US Patent:
2009008, Mar 26, 2009
Filed:
Nov 26, 2008
Appl. No.:
12/324554
Inventors:
Hui Cen - Palo Alto CA, US
International Classification:
G01N 33/53
G01N 33/00
G01N 33/566
US Classification:
435 72, 436 86, 436501
Abstract:
The present invention provides methods of selective enrichment of ligands present in a biological sample. One or a plurality of receptor carriers are used to capture ligands capable of binding to receptors immobilized on the surface of the receptor carriers. Receptor carriers bound with the ligands are separated from the remaining sample and the ligands are then eluted with a ligand elution solution to result in an enriched ligand sample. The enriched ligand sample may be used for further isolation of one or more ligands of interest, or for ligand profiling using 2-D gel electrophoresis coupled with mass spectrometry, for example. Such ligand profiling may have a number of applications, such as disease diagnosis, pathogen detection and drug screening.

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