Hui Qing Zhang, 476515 Rose Ellen Ave, Portage, IN 46368

6653443, Nov 25, 2003

Apr 8, 2002

10/118575

Hui Zhang - Philadelphia PA
Roger J. Pomerantz - Chalfont PA
Bin Yang - Bala Cynwyd PA

Thomas Jefferson University - Philadelphia PA

A61K 3804

530327, 530324, 530325, 530326, 530826

One approach to treating individuals infected with HIV-1 is to administer to such individuals compounds that directly interfere with and intervene in the machinery by which HIV-1 replicates itself within human cells. Although the specific role of HIV-1 viral protein Vif in the viral life cycle is not known, the vif gene is essential for the pathogenic replication of lentiviruses in vivo. The present invention relates to a method for treating an individual exposed to or infected with HIV-1. Individuals identified as being exposed to or infected by HIV-1 are administered a therapeutically effective amount of one or more compounds that inhibit or prevent replication of said HIV-1 by interfering with the replicative or other essential functions of HIV-1 viral protein Vif, by interactively blocking the multimerization domain of Vif, thereby preventing multimerization of Vif protein, which is important for Vif function in the lentivirus life cycle. In preferred embodiments, the compound or compounds that interactively block the multimerization domain of Vif are Vif antagonists. Pharmaceutical compositions comprising these compounds are also disclosed.

7226741, Jun 5, 2007

Oct 17, 2003

10/688100

Hui Zhang - Philadelphia PA, US
Roger J. Pomerantz - Chalfont PA, US
Bin Yang - Bala Cynwyd PA, US

Thomas Jefferson University - Philadelphia PA

C12Q 1/68

435 6, 435 911, 435 9133

One approach to treating individuals infected with HIV-1 is to administer to such individuals compounds that directly interfere with and intervene in the machinery by which HIV-1 replicates itself within human cells. Although the specific role of HIV-1 viral protein Vif in the viral life cycle is not known, the vif gene is essential for the pathogenic replication of lentiviruses in vivo. The present invention relates to a method for treating an individual exposed to or infected with HIV-1. Individuals identified as being exposed to or infected by HIV-1 are administered a therapeutically effective amount of one or more compounds that inhibit or prevent replication of said HIV-1 by interfering with the replicative or other essential functions of HIV-1 viral protein Vif by interactively blocking the multimerization domain of Vif, thereby preventing multimerization of Vif protein, which is important for Vif function in the lentivirus life cycle. In preferred embodiments, the compound or compounds that interactively block the multimerization domain of Vif are Vif antagonists. Pharmaceutical compositions comprising these compounds are also disclosed.

7498138, Mar 3, 2009

Jun 4, 2007

11/809953

Hui Zhang - Philadelphia PA, US
Roger J. Pomerantz - Chalfont PA, US
Bin Yang - Bala Cynwyd PA, US

Thomas Jefferson University - Philadelphia PA

C12Q 1/68

435 6, 435 911

The HIV-1 protein Vif comprises a multimerization domain that allows Vif-Vif interaction and Vif multimerization, which is important for Vif function in the HIV-1 life-cycle. A method for screening for an antagonist of Vif comprises contacting the multimerization domain of Vif with a test compound that specifically binds the multimerization domain. Antagonists identified by the screening assay inhibit Vif multimerization. The antagonists inhibit essential functions of Vif and accordingly are useful as inhibitors of HIV-1 replication.

8334255, Dec 18, 2012

Dec 4, 2007

12/448058

Hui Zhang - Voorhees NJ, US
Harold C. Smith - Rochester NY, US

Thomas Jefferson University - Philadelphia PA
OyaGen Inc. - Rochester NY

A61K 38/16
A61K 38/08
C07K 14/00
C07K 7/06
C07K 7/08

514 38, 514 11, 514 37, 530324, 530325, 530326, 530327, 530328

A compound of the formula X-M-SEQ ID NO:1, or a derivative thereof, is provided, wherein X-M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.

5763242, Jun 9, 1998

Feb 8, 1995

8/385446

Hui Zhang - Philadelphia PA
Roger J. Pomerantz - Chalfont PA

Thomas Jefferson University - Philadelphia PA

C12N 1500
C12N 1586
C12N 510

4351723

A method for improving the transduction efficiency of retroviral vectors into a host cell wherein the retroviral vectors are incubated with deoxyribonucleoside triphosphates prior to transduction into the host cell is provided.

2019007, Mar 14, 2019

Jul 12, 2018

16/033278

- Princeton NJ, US
Jianwu Xu - Lawrenceville NJ, US
Hui Zhang - Princeton Junction NJ, US

G06F 11/07

Systems and methods for automatically generating failure signatures in a computer system for performing computer system fault diagnosis are provided. The method includes receiving log data, converting each log in the log data into a collection of log pattern sequences including one or more log pattern sequences corresponding to one or more respective failure categories associated with the computer system, generating a collection of seed patterns by computing a global set of patterns from the collection of log pattern sequences, and extracting the collection of seed patterns from the global set of patterns, generating a log pattern grammar representation for each of the one or more log pattern sequences, generating a failure signature for each of the one or more failure categories based on the log pattern grammar representation and the collection of seed patterns, and employing the failure signatures to perform computer system fault diagnosis on new log data.

2017023, Aug 17, 2017

Nov 15, 2016

15/351449

- Princeton NJ, US
Jianwu Xu - Lawrenceville NJ, US
Hui Zhang - Princeton Junction NJ, US
Guofei Jiang - Princeton NJ, US

G06F 11/07
G06N 7/00
G06N 5/04

An exemplary method for detecting one or more anomalies in a system includes building a temporal causality graph describing functional relationship among local components in normal period; applying the causality graph as a propagation template to predict a system status by iteratively applying current system event signatures; and detecting the one or more anomalies of the system by examining related patterns on the template causality graph that specifies normal system behaviors. The system can aligning event patterns on the causality graph to determine an anomaly score.

2017023, Aug 17, 2017

Nov 15, 2016

15/351452

- Princeton NJ, US
Jianwu Xu - Lawrenceville NJ, US
Hui Zhang - Princeton Junction NJ, US
Guofei Jiang - Princeton NJ, US

G06K 9/46
G06F 17/30

Systems and methods are disclosed for parsing logs from arbitrary or unknown systems or applications by capturing heterogeneous logs from the arbitrary or unknown systems or applications; generating one pattern for every unique log message; building a pattern hierarchy tree by grouping patterns based on similarity metrics, and for every group it generates one pattern by combing all constituting patterns of that group; and selecting a set of patterns from the pattern hierarchy tree.