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Irwin D Bernstein, 824949 Stanford Ave NE, Seattle, WA 98105

Known as:
Irwin Tr Bernstein Irwin Ilene Bernstein Irwin Ile Bernstein Irvin D Bernstein Ilene L Bernstein Bernstein Irvin Tom Bodamer
Related to:
Dave Barry

Irwin Bernstein Phones & Addresses

4949 Stanford Ave NE, Seattle, WA 98105    206-4783858    206-5232249   

1230 NE 94Th St, Seattle, WA 98115   

65 Marion St, Seattle, WA 98104   

159 Four Wheel Dr, Lopez Island, WA 98261    360-4682841   

46 Hilltop Way, Lopez Island, WA 98261    206-5232249   

4949 Stanford Ave NE, Seattle, WA 98105    206-4783858   

Work

Company: Fred Hutchinson Cancer Research Address: 1100 Fairview Ave N Suite D2-373, Seattle, WA 98109 Phones: 206-6674886 (Phone)

Education

School / High School: New York University 1967

Languages

English

Awards

Healthgrades Honor Roll

Ranks

Certificate: Pediatric Oncology & Pediatric Hematology, 1974

Emails

i***[email protected]
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Mentions for Irwin D Bernstein

Career records & work history

Lawyers & Attorneys

Irwin Bernstein Photo 1

Irwin Bernstein - Lawyer

Licenses:
New York - Delinquent 1960
Education:
New York University School of Law
Irwin Bernstein Photo 2

Irwin Bernstein - Lawyer

Specialties:
Estate Planning, Insurance
ISLN:
909064721
Admitted:
1981
University:
University of Illinois, B.S., 1978
Law School:
Northwestern University, J.D., 1981

Medicine Doctors

Irwin Bernstein Photo 3

Dr. Irwin D Bernstein, Seattle WA - MD (Doctor of Medicine)

Specialties:
Pediatric Hematology & Oncology
Address:
Fred Hutchinson Cancer Research
1100 Fairview Ave N Suite D2-373, Seattle, WA 98109
206-6674886 (Phone)
Certifications:
Pediatric Oncology & Pediatric Hematology, 1974
Pediatrics, 1973
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
New York University
Graduated: 1967
Medical School
Children's Hospital Los Angeles
Graduated: 1967
Medical School
Chldns Hosp Med Ctr
Graduated: 1967

Irwin D. Bernstein

Specialties:
Hematology/Oncology, Pediatrics
Work:
Fred Hutchinson Cancer Research Center
1100 Fairview Ave N STE D3-100, Seattle, WA 98109
206-6674886 (phone) 206-6676084 (fax)
Education:
Medical School
New York University School of Medicine
Graduated: 1967
Languages:
English
Description:
Dr. Bernstein graduated from the New York University School of Medicine in 1967. He works in Seattle, WA and specializes in Hematology/Oncology and Pediatrics. Dr. Bernstein is affiliated with Seattle Childrens Hospital.
Irwin Bernstein Photo 4

Irwin David Bernstein, Seattle WA

Specialties:
Pediatrics
Pediatric Hematology-Oncology
Hematology & Oncology
Work:
Seattle Children's Hospital
4800 Sand Point Way NE, Seattle, WA 98105
Education:
New York University (1967)
Irwin Bernstein Photo 5

Irwin I Bernstein, Seattle WA

Specialties:
Pediatric Hematologist / Oncologist
Address:
4800 Sand Point Way Ne, Seattle, WA 98105
Education:
New York University, School of Medicine - Doctor of Medicine
Children's Hospital & Regional Medical Center - Fellowship - Pediatric Hematology/Oncology (Pediatrics)
Childrens Hospital Los Angeles - Residency - Pediatrics
Board certifications:
American Board of Pediatrics Certification in Pediatrics
American Board of Pediatrics Sub-certificate in Pediatric Hematology/Oncology (Pediatrics)

Irwin Bernstein resumes & CV records

Resumes

Irwin Bernstein Photo 16

Member

Location:
Seattle, WA
Industry:
Research
Work:
Fred Hutch
Member
Education:
New York University School of Medicine
Irwin Bernstein Photo 17

Irwin Bernstein

Publications & IP owners

Us Patents

Methods For Immortalizing Cells

US Patent:
7399633, Jul 15, 2008
Filed:
Oct 29, 2001
Appl. No.:
10/415310
Inventors:
Irwin D. Bernstein - Seattle WA, US
Barbara Varnum-Finney - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
C12N 5/08
US Classification:
435377, 435372
Abstract:
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the proliferation but not differentiation of the non-terminally differentiated cells. The present invention further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the invention can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The invention further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present invention and kits comprising reagents that promote the immortalization of precursor cells. The invention further provides methods for screening for Notch modulators and for identifying genes involved in processes of cellular differentiation.

Methods For Immortalizing Cells

US Patent:
8071377, Dec 6, 2011
Filed:
Jul 15, 2008
Appl. No.:
12/173185
Inventors:
Irwin D. Bernstein - Seattle WA, US
Barbara Varnum-Finney - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
C12N 5/02
US Classification:
435377, 435372
Abstract:
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the proliferation but not differentiation of the non-terminally differentiated cells. The present invention further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the invention can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The invention further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present invention and kits comprising reagents that promote the immortalization of precursor cells. The invention further provides methods for screening for Notch modulators and for identifying genes involved in processes of cellular differentiation.

Compositions And Methods For Providing Hematopoietic Function Without Hla Matching

US Patent:
2013009, Apr 18, 2013
Filed:
Apr 11, 2011
Appl. No.:
13/640297
Inventors:
Irwin D. Bernstein - Seattle WA, US
Colleen Delaney - Seattle WA, US
Assignee:
FRED HUTCHINSON CANCER RESEARCH CENTER - Seattle WA
International Classification:
A61K 35/48
G06F 19/00
US Classification:
424 937, 435372, 707758
Abstract:
The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.

Compositions And Methods For Providing Hematopoietic Function

US Patent:
2013009, Apr 18, 2013
Filed:
Apr 11, 2011
Appl. No.:
13/640298
Inventors:
Irwin D. Bernstein - Seattle WA, US
Colleen Delaney - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Reserach Center - Seattle WA
International Classification:
A61K 35/48
G06F 19/22
US Classification:
424 937, 435372, 707758
Abstract:
The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/pro-genitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.

Radiation Delivery To Lymphoid And Marrow Tissues

US Patent:
5273738, Dec 28, 1993
Filed:
Mar 3, 1990
Appl. No.:
7/562127
Inventors:
Dana C. Matthews - Seattle WA
Irwin D. Bernstein - Seattle WA
John A. Hansen - Mercer Island WA
Fred R. Appelbaum - Seattle WA
Claudio Anasetti - Seattle WA
Paul J. Martin - Seattle WA
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
A61K 4300
A61K 4902
US Classification:
424 11
Abstract:
A method of selectively delivering radiation homogeneously to lymphoid and marrow tissues in vivo including the step of administering an effective dose of a radiolabeled immunological binding partner of a T-200 antigen to a patient is disclosed. Also disclosed are immunological binding partners and compositions based thereon for carrying out the method.

Methods And Compositions For Adoptive T Cell Therapy Incorporating Induced Notch Signaling

US Patent:
2021029, Sep 23, 2021
Filed:
Aug 28, 2019
Appl. No.:
17/272117
Inventors:
- Seattle WA, US
Irwin D. Bernstein - Seattle WA, US
Margot J. Pont - Seattle WA, US
Assignee:
FRED HUTCHINSON CANCER RESEARCH CENTER - Seattle WA
International Classification:
C12N 5/0783
C07K 14/725
A61K 35/17
Abstract:
The disclosure provides in some aspect methods and compositions related to culturing and engineering T cells that maintain less differentiated state. The T cells are cultured in conditions that induce Notch signaling The resulting T cells exhibit maintenance of a less differentiated state for prolonged periods and have reduced susceptibility to exhaustion. Also provided are the cells produced by the methods, as well as related compositions and methods of use for adoptive therapy.

Expansion And Engraftment Of Stem Cells Using Notch 1 And/Or Notch 2 Agonists

US Patent:
2019012, May 2, 2019
Filed:
Dec 20, 2018
Appl. No.:
16/228069
Inventors:
- Seattle WA, US
Irwin D. Bernstein - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
C12N 5/0789
Abstract:
The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the disclosure can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The disclosure further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present disclosure and kits comprising reagents that promote the immortalization of precursor cells.

Expansion And Engraftment Of Stem Cells Using Notch 1 And/Or Notch 2 Agonists

US Patent:
2017010, Apr 20, 2017
Filed:
Jun 3, 2015
Appl. No.:
15/315660
Inventors:
- Seattle WA, US
Irwin D. Bernstein - Seattle WA, US
International Classification:
C12N 5/0789
Abstract:
The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the disclosure can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The disclosure further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present disclosure and kits comprising reagents that promote the immortalization of precursor cells.

Isbn (Books And Publications)

Primate Ecology And Human Origins: Ecological Influences On Social Organization

Author:
Irwin Samuel Bernstein
ISBN #:
0824070801

Possible Relatives

Cynthia S Bernstein  David Bernstein  Dale F Bernstein  Damon K Bernstein  Debra S Bernstein  Daniel Bernstein  Aaron Bernstein  Irwin M Joseph  Irwin S Kahn  Irwin M Keen 

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