James A Filice Deceased125 Moran Way, Santa Cruz, CA 95062

6371926, Apr 16, 2002

May 17, 2000

09/574607

Ted S. Thorson - Pleasanton CA
James A. Filice - Sunnyvale CA

Somnus Medical Technologies, Inc. - Sunnyvale CA

A61B 500

600549

Systems and methods are described for a wire based temperature sensing electrode for surgical procedures. A temperature sensing energy delivery device includes an elongated member having a groove formed in at least portion of the elongated member; and a first temperature sensor mechanically connected to the elongated member, the first temperature sensor including a first temperature sensor lead that is routed along the groove. The systems and methods provide advantages in that the wire based temperature sensing electrode for surgical procedures can simultaneously accommodate a temperature sensor and associated leads, exhibit sufficient strength without bulk, and be provided at lower cost.

6835194, Dec 28, 2004

Jun 27, 2002

10/188325

Randolph Mellus Johnson - Half Moon Bay CA
Felix Theeuwes - Los Altos Hills CA
Edward M. Gillis - Cupertino CA
Dana Litmanovitz - Sunnyvale CA
Barbara Laidlaw - San Jose CA
James Brown - Los Gatos CA
John Culwell - San Francisco CA
James A. Filice - Los Gatos CA
Peter Wickman - San Francisco CA
Andrew Poutiatine - Redwood City CA
John Dinka - Fairfax VA

Durect Corporation - Cupertino CA

A61K 922

6048901, 6048911, 604 9301, 604131, 604132, 604133, 424422, 424449

The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e. g. , sufentanil) over a protracted period of time (e. g. , at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

6911027, Jun 28, 2005

Apr 29, 1999

09/302055

Stuart D. Edwards - Portola Valley CA, US
James A. Filice - Los Gatos CA, US
Benjamin T. Nordell - Menlo Park CA, US
Brian O. Armijo - Mountain View CA, US

Somnus Medical Technologies, Inc. - Sunnyvale CA

A61B018/18

606 40, 606 49, 606 41, 604 22

A device for the ablation of tissue for use with the fingers of a human hand and a radio frequency power supply and controller providing a source of radio frequency energy and controls for controlling the application of radio frequency energy to the device comprising a handle sized so that is adapted to be grasped and supported by the human hand and having proximal and distal extremities. A single conductive needle formed of a conducting material is disposed in the distal extremity of the handle. An edge card is mounted in the handle and has edge mounted contacts with circuitry connected thereto. An edge mount board connector is mounted in the handle and is removably secured to the edge mounted contacts of the edge card. A cable is connected to the edge mount connector and extends from the proximal extremity of the handle and is adapted to be coupled to the radiofrequency power supply and controller. A second printed circuit board is mounted in the handle in a spaced-apart position from the edge card.

7648496, Jan 19, 2010

May 31, 2006

11/444934

Edward M. Gillis - San Jose CA, US
Andrew L. Poutiatine - Redwood CA, US
James A. Filice - Los Gatos CA, US
Peter Wickman - San Francisco CA, US
John Culwell - Los Gatos CA, US
John S. Dinka - Fairfax VA, US

Durect Corporation - Cupertino CA

A61K 9/22

6048911

Implantable delivery devices () for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir () for storing the agent, a driving means for driving the agent from the reservoir () and a valving and control mechanism () which is positively actuatable between a closed configuration and an open configuration.

2004019, Sep 30, 2004

Jan 29, 2004

10/707983

Edward Gillis - Santa Fe CA, US
James Filice - Los Gatos CA, US
Jim Brown - Los Gatos CA, US
Andrew Poutiatine - Redwood City CA, US
Charles Rampersaud - San Francisco CA, US
Danny Argonza - San Jose CA, US

DURECT CORPORATION - Cupertino CA

A61M005/178

604/164010

The present invention is a trocar/cannula assembly that is capable of delivering large-diameter objects/fluids into a body cavity interior, while minimizing the puncture footprint left after insertion. Generally, the invention could be a composite needle having a composite wall forming a trocar shaft with at least two rigid elements, and flexible material therebetween, which together at least partially define a trocar bore having a diameter, and a puncture tip. Together these elements enable the composite wall to flex outward so as to increase the diameter of the trocar bore. Additionally, the present invention could also be described as an expandable bore trocar/cannula that is made up of an expandable cannula body having an interior channel that is capable of flexing radially outward, and a trocar tip associated with the cannula body to facilitate the insertion of the trocar/cannula into a patient. Once the trocar/cannula is inserted, it may be flexed outward, and a medical implant may be inserted into the interior channel of the cannula body, and, in turn, into a body cavity of the patient.

2005007, Mar 31, 2005

Nov 21, 2001

10/433196

James Brown - Los Gatos CA, US
John Culwell - Mountain View CA, US
James Filice - Los Gatos CA, US
Edward Gillis - Cupertino CA, US
Felix Theeuwes - Los Altos Hills CA, US
Peter Wickman - San Francisco CA, US
Su Il Yum - Los Altos CA, US

A61K009/22

604890100

The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.

2005010, May 12, 2005

Aug 29, 2002

10/490331

Edward Gillis - San Jose CA, US
Andrew Poutiatine - Redwood City CA, US
James Filice - Los Gatos CA, US
Peter Wickman - San Francisco CA, US
John Culwell - Los Gatos CA, US

A61K009/22

604891100

Implantable delivery devices () for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir () for storing the agent, a driving means for driving the agent from the reservoir () and a valving and control mechanism () which is positively actuatable between a closed configuration and an open configuration.

2005010, May 19, 2005

Aug 18, 2004

10/922239

Edward Gillis - Cupertino CA, US
Barbara Laidlaw - San Jose CA, US
John Culwell - San Francisco CA, US
James Filice - Los Gatos CA, US
Peter Wickman - San Francisco CA, US
Andrew Poutiatine - Redwood City CA, US
John Dinka - Fairfax VA, US

A61K031/445
A61F002/00
A61K009/22

424423000, 514317000, 604890100

The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.