Inventors:
Samit Bhattacharya - Groton CT, US
Michael Luzzio - Noank CT, US
Donn Wishka - Mystic CT, US
Gonghua Pan - Old Lyme CT, US
Arthur Brosius - Niantic CT, US
Joel Arcari - Groton CT, US
James Southers - Norwich CT, US
Kendra Nelson - New London CT, US
Jun Xiao - Waterford CT, US
International Classification:
A61K 31/506
C07D 487/04
Abstract:
The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula and R, R, R, A, K, M, L, L, X, Y, Y, Q, salt thereof, wherein R, R, R, A, K, L, L, W, X, Z, Z, Y, Y, Z, Z, M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.