Janet G Forst, 58Phoenix, AZ
Janet Forst Phones & Addresses
Phoenix, AZ
3131 Saint Vincent St, Philadelphia, PA 19149 215-7083694
Phila, PA
Schenectady, NY
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Us Patents
Alpha-Substituted Pyridazino Quinoline Compounds
US Patent:
6737424, May 18, 2004
Filed:
Nov 16, 1998
Appl. No.:
09/192713
Inventors:
Thomas Michael Bare - West Chester PA
James Roy Empfield - Bear DE
Janet Marie Forst - Wilmington DE
Keith John Herzog - Wilmington DE
Richard Bruce Sparks - Linwood PA
James Roy Empfield - Bear DE
Janet Marie Forst - Wilmington DE
Keith John Herzog - Wilmington DE
Richard Bruce Sparks - Linwood PA
Assignee:
Zeneca Ltd. - London
International Classification:
A61K 315025
US Classification:
514248, 544230, 544234
Abstract:
Alpha-substituted pyridazino-quinoline compounds of formula Ia useful for the treatment of strokes and neurodegenerative disorders: wherein R is selected from a variety of substituents including halogen, (C -C )alkyl and nitro; R is selected from cycloalkyl moieties of 5-7 carbon atoms and the groups R2â and R2â as defined in the specification, a dashed bond indicates a single or double bond, and R is selected from H and CO(C -C )alkyl.
Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders
US Patent:
2009006, Mar 12, 2009
Filed:
Dec 22, 2005
Appl. No.:
11/793050
Inventors:
Michael Balestra - Wilmington DE, US
Heather Bunting - Wilmington DE, US
Deborah Chen - Biopolis Way, SG
Ian Egle - North York, CA
Janet Forst - Wilmington DE, US
Jennifer Frey - Brampton, CA
Methvin Isaac - Brampton, CA
Fupeng Ma - Brampton, CA
David Nugiel - Wilmington DE, US
Abdelmalik Slassi - Mississauga, CA
Gary Steelman - Wilmington DE, US
Guang-Ri Sun - Markham, CA
Babu Sundar - Wilmington DE, US
Radhakrishnan Ukkiramapandian - Salt Lake City UT, US
Rebecca Urbanek - Wilmington DE, US
Sally Walsh - Wilmington DE, US
Heather Bunting - Wilmington DE, US
Deborah Chen - Biopolis Way, SG
Ian Egle - North York, CA
Janet Forst - Wilmington DE, US
Jennifer Frey - Brampton, CA
Methvin Isaac - Brampton, CA
Fupeng Ma - Brampton, CA
David Nugiel - Wilmington DE, US
Abdelmalik Slassi - Mississauga, CA
Gary Steelman - Wilmington DE, US
Guang-Ri Sun - Markham, CA
Babu Sundar - Wilmington DE, US
Radhakrishnan Ukkiramapandian - Salt Lake City UT, US
Rebecca Urbanek - Wilmington DE, US
Sally Walsh - Wilmington DE, US
Assignee:
AstraZeneca AB - Sodertalje
International Classification:
A61K 31/496
C07D 471/10
A61K 31/438
C07D 401/06
A61P 25/16
A61P 25/28
A61K 31/454
C07D 403/06
C07D 471/10
A61K 31/438
C07D 401/06
A61P 25/16
A61P 25/28
A61K 31/454
C07D 403/06
US Classification:
51425405, 546 20, 514278, 546211, 514326, 544371
Abstract:
Compounds of Formula (I), wherein R, R, R, R, R, R, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.
Heterocyclic Derivatives
US Patent:
5455253, Oct 3, 1995
Filed:
Apr 14, 1994
Appl. No.:
8/227833
Inventors:
Cyrus J. Ohnmacht - Wilmington DE
Diane Trainor - Wilmington DE
Janet M. Forst - Wilmington DE
Mark M. Stein - Wilmington DE
Robert J. Harris - Wilmington DE
Diane Trainor - Wilmington DE
Janet M. Forst - Wilmington DE
Mark M. Stein - Wilmington DE
Robert J. Harris - Wilmington DE
Assignee:
Zeneca Limited
International Classification:
C07D21520
C07D40504
A61K 31435
C07D40504
A61K 31435
US Classification:
514311
Abstract:
Compounds of formula I ##STR1## wherein R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 10 and R. sup. 11 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinery incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Alpha-Substituted Pyridazino Quinoline Compounds
US Patent:
5837705, Nov 17, 1998
Filed:
Apr 1, 1996
Appl. No.:
8/617728
Inventors:
Thomas Michael Bare - West Chester PA
James Roy Empfield - Bear DE
Janet Marie Forst - Wilmington DE
Keith John Herzog - Wilmington DE
Richard Bruce Sparks - Linwood PA
James Roy Empfield - Bear DE
Janet Marie Forst - Wilmington DE
Keith John Herzog - Wilmington DE
Richard Bruce Sparks - Linwood PA
Assignee:
Zeneca Limited - London
International Classification:
A61K 3150
C07D47104
C07D47114
C07D49114
C07D47104
C07D47114
C07D49114
US Classification:
514248
Abstract:
The invention relates to alpha-substituted pyridazino-quinoline compounds of the formula I: ##STR1## wherein Ring A is chosen from an ortho fused aromatic or heteroaromatic five- or six-membered ring; R. sup. 1 is selected from a variety of substituents including halogen, (1-4C)alkyl and nitro; R. sup. 2 is selected from a group of the formula R2', R2" or R2"' wherein R2' is --CHR. sup. 3 (CH. sub. 2). sub. n C(O)NR. sup. 5 R. sup. 6 ; R2" is --CHR. sup. 3 (CH. sub. 2). sub. n R. sup. 4 and R2"' is --CHR. sup. 3 (CH. sub. 2). sub. n L wherein n is 0-6; R. sup. 5 is aryl or substituted aryl; R. sup. 6 is (1-6C)alkyl or hydrogen; R. sup. 3 is (1-6C)alkyl, (0-6C)alkylCF. sub. 3 or (0-6C)alkylCOOR'; R. sup. 4 is (1-6C)alkyl, (2-6C)alkyl containing a double or triple bond, or (0-6C)alkylaryl; L is a variety of substituents including phenyl, heteroaryl and CO. sub. 2 R'; R' is hydrogen or (1-4C)alkyl; Z is selected from oxo, --OH, H,H--, H, (1-6C)alkyl or (1-6C)alkylaryl; and R. sup.
Heterocyclic Derivatives
US Patent:
5622964, Apr 22, 1997
Filed:
Aug 18, 1995
Appl. No.:
8/516713
Inventors:
Cyrus J. Ohnmacht - Wilmington DE
Diane A. Trainor - Wilmington DE
Janet M. Forst - Wilmington DE
Mark M. Stein - Wilmington DE
Robert J. Harris - Wilmington DE
Diane A. Trainor - Wilmington DE
Janet M. Forst - Wilmington DE
Mark M. Stein - Wilmington DE
Robert J. Harris - Wilmington DE
Assignee:
Zeneca Limited - London
International Classification:
C07D40504
C07D21520
A61K 31435
C07D21520
A61K 31435
US Classification:
514311
Abstract:
Methods of treating asthma are provided which methods comprise administering to a mammal in need of such treatment an effective amount of a compound of Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 10 and R. sup. 11 have any of the meanings given in the specification.
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