Javier Farinas resumes & CV records
Resumes
Javier A Farinas, 581644 Kensington Ave, Los Altos, CA 94024
Javier Farinas Phones & Addresses
1644 Kensington Ave, Los Altos Hills, CA 94024 650-9628514 650-9628516
Los Altos, CA
75 Coronado Ave, San Carlos, CA 94070 650-5080824
Belmont, CA
San Francisco, CA
Parsippany, NJ
Menlo Park, CA
Palo Alto, CA
Santa Clara, CA
1644 Kensington Ave, Los Altos, CA 94024 650-8140500
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Javier A Farinas
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Professional/Technical
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Graduate or professional degree
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Us Patents
Optical Detection Of Transmembrane Potential Changes
US Patent:
6468763, Oct 22, 2002
Filed:
Sep 14, 2000
Appl. No.:
09/661337
Inventors:
Javier A. Farinas - San Carlos CA
Assignee:
Caliper Technologies Corp. - Mountain View CA
International Classification:
C12Q 102
US Classification:
435 29, 435968, 435 4, 4351734, 436 63, 436172
Abstract:
Compositions for monitoring transmembrane potential across cellular membranes. The compositions typically comprise a cell having a plasma membrane that comprises a first leaflet and a second leaflet, the membrane comprising first and second membrane associated components which, when placed adjacent each other either produce or quench a fluorescent signal, wherein. The first membrane associated component translocates from a first leaflet of the membrane to a second leaflet of the membrane in response to an electrical potential gradient across the membrane, the first membrane associated component being selected from a non-fluorescent cationic fluorescence quencher a non-fluorescent anionic fluorescence quencher and a cationic fluorophore.
Use Of Nernstein Voltage Sensitive Dyes In Measuring Transmembrane Voltage
US Patent:
6537771, Mar 25, 2003
Filed:
Oct 6, 2000
Appl. No.:
09/684313
Inventors:
Javier Anibal Farinas - San Carlos CA
H. Garrett Wada - Atherton CA
H. Garrett Wada - Atherton CA
Assignee:
Caliper Technologies Corp. - Mountain View CA
International Classification:
C12Q 102
US Classification:
435 29, 435 4, 435968, 435 72
Abstract:
Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for transmembrane potential measurements.
Focusing Of Microparticles In Microfluidic Systems
US Patent:
6592821, Jul 15, 2003
Filed:
May 10, 2001
Appl. No.:
09/853887
Inventors:
H. Garrett Wada - Atherton CA
Anne R. Kopf-Sill - Portola Valley CA
Marja Liisa Alajoki - Palo Alto CA
J. Wallace Parce - Palo Alto CA
Benjamin N. Wang - Palo Alto CA
Andrea W. Chow - Los Altos CA
Robert S. Dubrow - San Carlos CA
Yevgeny Yurkovetsky - San Jose CA
Javier Anibal Farinas - San Carlos CA
Anne R. Kopf-Sill - Portola Valley CA
Marja Liisa Alajoki - Palo Alto CA
J. Wallace Parce - Palo Alto CA
Benjamin N. Wang - Palo Alto CA
Andrea W. Chow - Los Altos CA
Robert S. Dubrow - San Carlos CA
Yevgeny Yurkovetsky - San Jose CA
Javier Anibal Farinas - San Carlos CA
Assignee:
Caliper Technologies Corp. - Mountain View CA
International Classification:
G01N 3348
US Classification:
422 681, 422 50, 422 58, 422 81, 422 8205, 422 8208, 422 8209, 436 43, 436 63, 435 4, 435 71
Abstract:
Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
Use Of Nernstein Voltage Sensitive Dyes In Measuring Transmembrane Voltage
US Patent:
6759191, Jul 6, 2004
Filed:
Jan 21, 2003
Appl. No.:
10/349396
Inventors:
Javier Anibal Farinas - San Carlos CA
H. Garrett Wada - Atherton CA
H. Garrett Wada - Atherton CA
Assignee:
Caliper Life Sciences, Inc. - Mountain View CA
International Classification:
C12Q 100
US Classification:
435 4, 4352831, 4352852, 4352865
Abstract:
Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for transmembrane potential measurements.
Use Of Nernstein Voltage Sensitive Dyes In Measuring Transmembrane Voltage
US Patent:
6979553, Dec 27, 2005
Filed:
Sep 5, 2003
Appl. No.:
10/655697
Inventors:
Javier Anibal Farinas - San Carlos CA, US
H. Garrett Wada - Atherton CA, US
H. Garrett Wada - Atherton CA, US
Assignee:
Caliper Life Sciences, Inc. - Mountain View CA
International Classification:
C12Q001/02
C12Q001/00
G01N033/53
C12Q001/00
G01N033/53
US Classification:
435 29, 435 4, 435 72, 435968
Abstract:
Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for transmembrane potential measurements.
Methods And Reagents For Targeting Organic Compounds To Selected Cellular Locations
US Patent:
7045305, May 16, 2006
Filed:
Apr 8, 1999
Appl. No.:
09/403882
Inventors:
Javier Farinas - Los Altos CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01N 33/53
C12N 15/13
C12P 21/08
C07H 21/04
C12N 15/13
C12P 21/08
C07H 21/04
US Classification:
435 721, 4353201, 5303873, 536 231
Abstract:
The present invention provides methods and reagents for targeting probes to selected cellular locations, through the expression of specific binding partners to that probe within the cell. In one embodiment, the probes may comprise spectroscopic probe that can be used in a method for localizing a specific binding partner within a cell, and for creating assays for post-translational activities. The invention allows the monitoring of the location of such intracellular specific binding partners over time and in response to stimuli, such as test chemicals. The spectroscopic probes can be used for screening a test chemical for activity. The present invention also includes cells and transgenic organisms comprising the intracellular specific binding partner, wherein the specific binding partner can bind with the spectroscopic probe/ligand conjugate.
Screening Assay Methods And Systems Using Target Pooling
US Patent:
2001003, Nov 1, 2001
Filed:
Apr 10, 2001
Appl. No.:
09/833080
Inventors:
Javier Farinas - San Carlos CA, US
H. Wada - Atherton CA, US
H. Wada - Atherton CA, US
International Classification:
C12Q001/00
G01N033/53
C12M001/34
G01N033/53
C12M001/34
US Classification:
435/004000, 435/007100, 435/287100
Abstract:
Methods, devices and systems for increasing the throughput of screening assays by pooling multiple target systems, which allow a library of different materials, e.g., test compounds, to be screened against the pooled targets to determine whether any of the materials affect one or more of the target systems. In preferred aspects, functioning of individual target systems is identified by differences in physical, chemical and/or optical properties particular to the target system in a target pool.
Methods And Systems For Monitoring Intracellular Binding Reactions
US Patent:
2002000, Jan 24, 2002
Filed:
Dec 28, 2000
Appl. No.:
09/750638
Inventors:
H. Wada - Atherton CA, US
Javier Farinas - San Carlos CA, US
Theo Nikiforov - San Jose CA, US
Javier Farinas - San Carlos CA, US
Theo Nikiforov - San Jose CA, US
International Classification:
C12Q001/00
C12Q001/68
C12Q001/68
US Classification:
435/004000, 435/006000
Abstract:
Intracellular binding reactions, and particularly DNA/DNA binding protein reactions are detected in situ, using intracellular fluorescence polarization detection. The methods comprise providing a biological cell having at least a first component of a binding reaction disposed therein. The cell is contacted with a second component of the binding reaction whereby the second component is internalized within the biological cell. At least one of the first and second components has a fluorescent label. The amount of binding between the first and second components within the cell is determined by measuring a level of polarized and/or depolarized fluorescence emitted from within the biological cell.
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