Jeff Sebastian resumes & CV records
Resumes
Jeff Sebastian
Jeff Sebastian
Jeff Sebastian
Jeff Sebastian
Jeff D Sebastian, 584820 Colonial Rd, Roseburg, OR 97470
Jeff Sebastian Phones & Addresses
4820 Colonial Rd, Roseburg, OR 97470 541-9571752
Anaheim, CA
Mentions for Jeff D Sebastian
Publications & IP owners
Us Patents
Use Of Recipient Endothelial Cells For Enhanced Vascularization Of Tissue And Tissue-Engineered Construct Transplants
US Patent:
2003011, Jun 19, 2003
Filed:
Aug 30, 2002
Appl. No.:
10/233005
Inventors:
Elena Revazova - Los Angeles CA, US
Jeff Sebastian - Los Angeles CA, US
Jeff Sebastian - Los Angeles CA, US
International Classification:
A61K048/00
C12N005/08
C12N005/08
US Classification:
424/093210, 424/093700, 435/366000
Abstract:
The success of tissue transplantation, when immunological conflict is minimized, depends on the vascularization process. This process is very complex and requires time. During this time, transplanted tissue often has difficulty obtaining oxygen and nutrients. These factors have a profound influence on the survival of the transplanted tissue, especially if the tissue has poor angiogenic properties. For new vessel formation, endothelial cells from existing recipient microvessels must proliferate and migrate through the extracellular matrix into the transplanted tissue. However, if transplanted tissue is mixed with recipient endothelial cells or co-administered, vascularization and acceptance of auto-, allo-, and heterotransplants is enhanced. In addition, recipient endothelial cells can be used to enhance vascularization of three-dimensional tissue-engineered constructs.
Use Of Low-Power Laser Irradiation For Enhanced Vascularization Of Tissue And Tissue-Engineered Construct Transplants
US Patent:
2003011, Jun 19, 2003
Filed:
Aug 30, 2002
Appl. No.:
10/233004
Inventors:
Elena Revazova - Los Angeles CA, US
Jeff Sebastian - Los Angeles CA, US
Jeff Sebastian - Los Angeles CA, US
International Classification:
A61N001/00
A61B019/00
A61B019/00
US Classification:
128/898000, 607/089000
Abstract:
The success of tissue transplantation, when immunological conflict is minimized, depends on the vascularization process. This process is very complex and requires time. During this time, transplanted tissue often has difficulty obtaining oxygen and nutrients. These factors have a profound influence on the survival of the transplanted tissue, especially if the tissue has poor angiogenic properties. For new vessel formation, endothelial cells from existing recipient microvessels must proliferate and migrate through the extracellular matrix into the transplanted tissue. However, if transplanted tissue is irradiated with low-power laser, vascularization and acceptance of auto-, allo-, and heterotransplants is enhanced.
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