Jamal M Ali, 5185 Oceanic Ave, Staten Island, NY 10312

6853926, Feb 8, 2005

Jun 5, 2003

10/455662

Robert R. Alfano - Bronx NY, US
Iosif Zeylikovich - Brooklyn NY, US
Wubao Wang - Flushing NY, US
Jamal Ali - Brooklyn NY, US
Vincent Benischek - Shrub Oak NY, US
Yury Budansky - Oakland NJ, US

Research Foundation of CUNY - New York NY
Lockheed Martin Corporation - Bethesda MD

G01B005/28

702 40, 702155, 702159, 2503991, 2503418

The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface, comprising a mid-infrared (MIR) detection unit for illuminating an area of the coated surface and detecting light reflected from the illuminated area of the coated surface, and a processing unit for producing an image from optical characteristics received from the MIR detection unit. In addition, the system may further comprise a scanning unit for moving the MIR detection unit to a next area.

7038208, May 2, 2006

Sep 2, 2003

10/653473

Robert R. Alfano - Bronx NY, US
Iosif Zeylikovich - Brooklyn NY, US
Wubao Wang - Flushing NY, US
Jamal Ali - Brooklyn NY, US
Vincent Benischek - Shrub Oak NY, US
Yury Budansky - Oakland NJ, US

The Research Foundation of the City of New York - New York NY
Lockheed Martin Corporation - Bethesda MD

G01N 21/88

2503411

The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface, comprising a mid-infrared (MIR) illumination unit for illuminating an area of the coated surface, and an MIR 2-D imager, which includes an MIR CCD or CMOS camera, for capturing an image of a material abnormalities under the illuminated area of the coated surface. In addition, the system may further comprise a scanning unit for moving the system to a next area.

7706862, Apr 27, 2010

Aug 26, 2004

10/926556

Robert R. Alfano - Bronx NY, US
Jamal H. Ali - Brooklyn NY, US
Wubao Wang - Flushing NY, US
Manuel Zevallos - Woodhaven NY, US

Research Foundation of the City University of New York - New York NY

A61B 6/00
A61B 5/00

600473, 600475, 600477, 600310

Spectral optical imaging at one or more key water absorption fingerprint wavelengths measures the difference in water content between a region of cancerous or precancerous tissue and a region of normal tissue. Water content is an important diagnostic parameter because cancerous and precancerous tissues have different water content than normal tissues. Key water absorption wavelengths include at least one of 980 nanometers (nm), 1195 nm, 1456 nm, 1944 nm, 2880 nm to 3360 nm, and 4720 nm. In the range of 400 nm to 6000 nm, one or more points of negligible water absorption are used as reference points for a comparison with one or more key neighboring water absorption wavelengths. Different images are generated using at least two wavelengths, including a water absorption wavelength and a negligible water absorption wavelength, to yield diagnostic information relevant for classifying a tissue region as cancerous, precancerous, or normal. The results of this comparison can be used to identify regions of cancerous tissue in organs such as the breast, cervix and prostate.

2006017, Aug 3, 2006

Apr 16, 2004

10/825742

Robert Alfano - Bronx NY, US
Jamal Ali - Brooklyn NY, US
Wubao Wang - Flushing NY, US
Manuel Zevallos - Woodhaven NY, US

A61B 6/00

600476000, 600478000

Spectral optical imaging at one or more key water absorption fingerprint wavelengths measures the difference in water content between a region of cancerous or precancerous tissue and a region of normal tissue. Water content is an important diagnostic parameter because cancerous and precanerous tissues have different water content than normal tissues. Key water absorption wavelengths include at least one of 980 nanometers (nm), 1195 nm, 1456 nm, 1944 nm, 2880 nm to 3360 nm, and 4720 nm. In the range of 400 nm to 6000 nm, one or more points of negligible water absorption are used as reference points for a comparison with one or more key neighboring water absorption wavelengths. Different images are generated using at least two wavelengths, including a water absorption wavelength and a negligible water absorption wavelength, to yield diagnostic information relevant for classifying a tissue region as cancerous, precancerous, or normal. The results of this comparison can be used to identify regions of cancerous tissue in organs such as the breast, cervix and prostate.

6280386, Aug 28, 2001

Jun 16, 1998

9/098258

Robert R. Alfano - Bronx NY
Stavros G. Demos - Livermore CA
Wubao Wang - Flushing NY
Jamal Ali - Brooklyn NY

The Research Foundation of the City University of New York - New York NY

A61B 500

600431

Imaging of objects within tissue is enhanced by applying a contrast agent to a sample to be imaged to augment the emissions from an object, thereby forming a luminous object. The tissue is then illuminated and two image signals are recorded. The contrast agent is selected to bind to the object and provide spectral characteristics significantly different from that of the tissue for the two recorded image signals. The two image signals are subtracted to substantially minimize an image component resulting from the tissue and enhance an image component from the luminous object. The imaging methods and apparatus are particularly well suited for medical imaging where the object is diseased tissue such as tumors.