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Jennifer C Leeds, 37Peterborough, NH

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Peterborough, NH   

Wilton, NH   

Bristol, NH   

Worcester, MA   

Brookline, NH   

22 W Hill Rd, Brookline, NH 03033   

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Us Patents

N-Formyl Hydrozyamine Compounds

US Patent:
2009006, Mar 5, 2009
Filed:
Mar 2, 2007
Appl. No.:
12/280896
Inventors:
Kwangho Lee - Lexington MA, US
Jennifer A. Leeds - Arlington MA, US
International Classification:
C07D 403/12
C07D 401/12
US Classification:
544238, 5462791, 544336
Abstract:
Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.

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