Inventors:
Vijayalakshmi Shridhar - Rochester MN, US
Jeremy R. Chien - Rochester MN, US
Brian C. Brost - Rochester MN, US
Funminiyi A. Ajayi - Rochester MN, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
International Classification:
G01N 33/53
G01N 33/00
Abstract:
This document relates to methods and materials involved in identifying, predicting, and treating pre-eclampsia or a cardiovascular disease (e.g., atherosclerosis) in mammals. For example, methods and materials involved in using serum levels of HtrA polypeptides to identify pre-eclampsia or a cardiovascular disease, using HTRA polymorphisms to predict pre-eclampsia or a cardiovascular disease, and using HtrA antibodies to treat pre-eclampsia or a cardiovascular disease in mammals (e.g., humans) are provided.