Fang Yu Hu, 42Chattanooga, TN

2004020, Oct 14, 2004

Jan 28, 2004

10/766307

Fang Hu - Castro Valley CA, US
Bo Wu - Urbana IL, US

Shanghai Sunway Biotech Co., Ltd. - Shanghai

A61K038/48
A61K039/395

424/155100, 424/094630

The present invention relates to compositions and methods for ablating tumor cells in a subject having at least one tumor site. More specifically, the method comprises contacting the tumor cells in at least one tumor with a lytic agent in vivo, under lytic conditions, forming a treated tumor; and applying a sufficient in vivo stimulus to the treated tumor forming a stimulated tumor. Compositions and methods are included for shrinking a local tumor or a distal metastatic tumor, or both in a subject. In a preferred embodiment, the method for shrinking a tumor in a subject comprises: contacting a stimulated tumor cells in vivo with a lytic agent. The stimulus directed toward the tumor cells is capable of increasing the level of chaperone proteins in the tumor cells. The combination of lytic agents and tumor cell stimulus leads to shrinkage of the tumors that were treated directly, wherein the stimulus is either applied simultaneously or sequentially. Moreover, distal or metastatic tumors that were not-treated directly are also decreased by introducing a lytic agents into a stimulated tumor cells in a first-tumor (“the treated tumor” or “the local tumor”). The preferred method steps that include introduction of a lytic agent and stimulation of the tumor cells is repeated in order to maximize the tumor shrinkage effects.

2009005, Feb 26, 2009

Apr 29, 2008

12/150557

Fang Hu - Castro Valley CA, US
Bo Wu - Urbana IL, US

Shanghai Sunway Biotech Co., Ltd. - Shanghai

A61K 35/74
A61K 35/76
A61K 31/7088

424 9341, 424 936, 424 934, 514 44

The present invention relates to compositions and methods for ablating tumor cells in a subject having at least one tumor site. More specifically, the method comprises contacting the tumor cells in at least one tumor with a lytic agent in vivo, under lytic conditions, forming a treated tumor; and applying a sufficient in vivo stimulus to the treated tumor forming a stimulated tumor. Compositions and methods are included for shrinking a local tumor or a distal metastatic tumor, or both in a subject. In a preferred embodiment, the method for shrinking a tumor in a subject comprises: contacting a stimulated tumor cells in vivo with a lytic agent. The stimulus directed toward the tumor cells is capable of increasing the level of chaperone proteins in the tumor cells. The combination of lytic agents and tumor cell stimulus leads to shrinkage of the tumors that were treated directly, wherein the stimulus is either applied simultaneously or sequentially. Moreover, distal or metastatic tumors that were not-treated directly are also decreased by introducing a lytic agents into a stimulated tumor cells in a first-tumor (“the treated tumor” or “the local tumor”). The preferred method steps that include introduction of a lytic agent and stimulation of the tumor cells is repeated in order to maximize the tumor shrinkage effects.

2016000, Jan 7, 2016

Jul 3, 2014

14/323778

Ling Zhou - Dublin CA, US
Fang Hu - Dublin CA, US

A62B 18/02
A61L 9/20
A41D 13/11
A62B 7/10
A62B 18/10

A breathing apparatus according to embodiments of the invention includes a facemask portion sized to cover a lower portion of a wearer's face. The facemask portion includes a flow chamber. The flow chamber includes a first opening disposed near a first end of the flow chamber, a second opening disposed near a second end of the flow chamber, and a serpentine passage disposed between the first opening and the second opening. At least one light emitting diode configured to emit light having a peak wavelength in the ultraviolet range is disposed in the serpentine passage. The at least one light emitting diode is disposed off center relative to a centerline oriented along a direction of air flow through the serpentine passage.