Sheng D Fang Deceased3872 Greenwich Ave, Duluth, GA 30096

6509480, Jan 21, 2003

Oct 23, 2001

10/047182

Dilip R. Wagle - Nanuet NY
Sheng Ding Fang - Mahwah NJ
Ihor Terleckyj - Ridgewood NJ
John Resek - Brooklyn NY
John J. Egan - New York NY

Alteon, Inc. - Ramsey NJ

C07D40700

549299, 548525, 560126, 562510, 562511

Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: wherein the dotted line between carbons 5 and 6, the dotted line between carbon 4 and R , and the dotted line between carbon 11 and R each independently represent an optional double bond from the respective numbered carbon to a linked carbon, and wherein X is hydroxy or, together with Y is oxy linking carbon 8 and carbon 12.

6610716, Aug 26, 2003

Jul 13, 2001

09/905035

Dilip R. Wagle - New York NY
Sheng Ding Fang - Mount Kisco NY

Alteon Incorporated - Ramsey NJ

A61K 314164

514365, 514367, 514394, 514399, 548152, 548202, 548205, 5483097, 5483361

Provided, among other things, is a compound of the formula:.

6777557, Aug 17, 2004

Feb 7, 2002

10/072712

Peter C Ulrich - Portland OR, 97229
Sheng Ding Fang - Mount Kisco NY, 10549
Michael L Brines - Woodbridge CT, 06525
Qiao-Wen Xie - Yonkers NY, 10710
Anthony Cerami - Sleepy Hollow NY, 10591

C07D27784

548366, 548150

In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.

7022721, Apr 4, 2006

Mar 8, 2004

10/794024

Peter C Ulrich - Portland OR, US
Sheng Ding Fang - Mount Kisco NY, US
Michael L Brines - Woodbridge CT, US
Qiao-Wen Xie - Yonkers NY, US
Anthony Cerami - Sleepy Hollow NY, US

A61K 31/428
C07D 277/84

514366, 548366, 548150

In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.

2004023, Nov 25, 2004

Jun 21, 2004

10/873056

John Egan - New York NY, US
Sara Vasan - New York NY, US
Martin Gall - Morristown NJ, US
Sheng Fang - Mount Kisco NY, US
Pramod Wagle - Pune, IN
Dilip Wagle - Pune, IN

A61K031/541
A61K031/5377
A61K031/497
A61K031/496
A61K031/454
A61K031/422

514/227500, 514/374000, 514/252050, 514/255050, 514/256000, 514/235200, 514/254020, 514/326000, 514/340000

Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:

2005003, Feb 10, 2005

Aug 21, 2003

10/645011

Dilip Wagle - Pune, IN
Sheng Fang - Mount Kisco NY, US

A61K031/417
C07D233/90

514399000, 548336100

Provided, among other things, is a compound of the formula:

2005024, Nov 3, 2005

Jul 5, 2005

11/175098

Peter Ulrich - Portland OR, US
Sheng Fang - Mount Kisco NY, US
Michael Brines - Woodbridge CT, US
Qiao-Wen Xie - Yonkers NY, US
Anthony Cerami - Sleepy Hollow NY, US

C07D498/02
C07D265/36

514230500, 514365000, 544105000, 548204000, 544332000, 546341000

In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.

2007009, May 3, 2007

May 10, 2006

11/432034

Dilip Wagle - Pune, IN
Sheng Fang - Mount Kisco NY, US

A61K 31/541
A61K 31/5377
A61K 31/496
A61K 31/454
A61K 31/4184
A61K 31/4178
C07D 417/02
C07D 413/02
C07D 403/02

514210200, 514227500, 514235500, 514254050, 514326000, 514397000, 544060000, 544139000, 544370000, 546210000, 548311100, 424440000, 424451000

Provided, among other things, is a compound of the formula: