Jian Zhi Hu, 63Richland, WA

6653832, Nov 25, 2003

Mar 9, 2001

09/803381

Robert A. Wind - West Richland WA
Jian Zhi Hu - Richland WA

Battelle Memorial Institute - Richland WA

G01L 300

324307, 324309, 324314

A method of performing a magnetic resonance analysis of a biological object that includes placing the biological object in a main magnetic field and in a radio frequency field, the main magnetic field having a static field direction; rotating the biological object at a rotational frequency of less than about 100 Hz around an axis positioned at an angle of about 54Â44â relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. According to another embodiment, the radio frequency is pulsed to provide a sequence capable of producing a spectrum that is substantially free of spinning sideband peaks.

6670811, Dec 30, 2003

Mar 7, 2002

10/094455

Robert A. Wind - West Richland WA
Jian Zhi Hu - Richland WA

Battelle Memorial Institute - Richland WA

G01V 300

324307, 324309, 324314

A method of performing a magnetic resonance analysis of a biological object that includes placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54Â44â relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. The object may be reoriented about the magic angle axis between three predetermined positions that are related to each other by 120Â. The main magnetic field may be rotated mechanically or electronically. Methods for magnetic resonance imaging of the object are also described.

6836115, Dec 28, 2004

Jun 5, 2003

10/456272

Robert A. Wind - West Richland WA
Jian Zhi Hu - Richland WA

Battelle Memorial Institute - Richland WA

G01V 300

324307, 324309, 324314

A method of performing a magnetic resonance analysis of a biological object that includes placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54Â44â relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. The object may be reoriented about the magic angle axis between three predetermined positions that are related to each other by 120Â. The main magnetic field may be rotated mechanically or electronically. Methods for magnetic resonance imaging of the object are also described.

6989674, Jan 24, 2006

Aug 12, 2003

10/639828

Robert A. Wind - West Richland WA, US
Jian Zhi Hu - Richland WA, US
Kevin R. Minard - Kennewick WA, US
Donald N. Rommereim - Pasco WA, US

Battelle Memorial Institute - Richland WA

G01V 3/00

324321, 324318

The present invention relates to a probe and processes useful for magnetic resonance imaging and spectroscopy instruments. More particularly, the invention relates to a MR probe and processes for obtaining resolution enhancements of fluid objects, including live specimens, using an ultra-slow (magic angle) spinning (MAS) of the specimen combined with a modified phase-corrected magic angle turning (PHORMAT) pulse sequence. Proton NMR spectra were measured of the torso and the top part of the belly of a female BALBc mouse in a 2T field, while spinning the animal at a speed of 1. 5 Hz. Results show that even in this relatively low field with PHORMAT, an isotropic spectrum is obtained with line widths that are a factor 4. 6 smaller than those obtained in a stationary mouse. Resolution of H NMR metabolite spectra are thus significantly enhanced.

7535224, May 19, 2009

May 29, 2007

11/754660

Jian Zhi Hu - Richland WA, US
David W. Hoyt - Richland WA, US
Robert A. Wind - Kennewick WA, US

G01V 3/00

324307, 324321

Described are a “Discrete Magic Angle Turning” (DMAT) system, devices, and processes that combine advantages of both magic angle turning (MAT) and magic angle hopping (MAH) suitable, e. g. , for in situ magnetic resonance spectroscopy and/or imaging. In an exemplary system, device, and process, samples are rotated in a clockwise direction followed by an anticlockwise direction of exactly the same amount. Rotation proceeds through an angle that is typically greater than about 240 degrees but less than or equal to about 360 degrees at constant speed for a time applicable to the evolution dimension. Back and forth rotation can be synchronized and repeated with a special radio frequency (RF) pulse sequence to produce an isotropic-anisotropic shift 2D correlation spectrum. The design permits tubes to be inserted into the sample container without introducing plumbing interferences, further allowing control over such conditions as temperature, pressure, flow conditions, and feed compositions, thus permitting true in-situ investigations to be carried out.

8064982, Nov 22, 2011

Nov 21, 2006

11/562390

Jian Zhi Hu - Richland WA, US
Robert A. Wind - Kennewick WA, US
Kevin R. Minard - Kennewick WA, US
Paul D. Majors - Kennewick WA, US

Battelle Memorial Institute - Richland WA

A61B 5/055

600410, 600407, 324307, 324309, 324314

Methods of performing a magnetic resonance analysis of a biological object are disclosed that include placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 5444′ relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. In particular embodiments the method includes pulsing the radio frequency to provide at least two of a spatially selective read pulse, a spatially selective phase pulse, and a spatially selective storage pulse. Further disclosed methods provide pulse sequences that provide extended imaging capabilities, such as chemical shift imaging or multiple-voxel data acquisition.

2012014, Jun 14, 2012

Jul 28, 2011

13/193172

David W. Hoyt - Richland WA, US
Romulus V. F. Turcu - Richland WA, US
Kevin M. Rosso - West Richland WA, US
Jian Zhi Hu - Richland WA, US

BATTELLE MEMORIAL INSTITUTE - Richland WA

G01R 33/46
G01R 33/30

324307, 324321

A high-pressure magic angle spinning (MAS) rotor is detailed that includes a high-pressure sample cell that maintains high pressures exceeding 150 bar. The sample cell design minimizes pressure losses due to penetration over an extended period of time.

2013025, Oct 3, 2013

Mar 28, 2012

13/433038

Jian Zhi Hu - Richland WA, US
Ju Feng - Richland WA, US
Hardeep S. Mehta - Kennewick WA, US

BATTELLE MEMORIAL INSTITUTE - Richland WA

G01R 3/00

324322

A slow Magic-Angle Spinning NMR device and method are detailed that provide high resolution and high sensitivity metabolic profiling of biological samples. A new H-PASS sequence suppresses line broadening in the various biological samples. The device and method allow metabolic changes in small animals to be tracked through continuous investigations of minimally-invasive blood and tissue biopsy samples over a sustained period and allow intact biological objects with sizes up to a few centimeters to be studied.