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Jie Xia, 44Washington, DC

Related to:
Xi Yang 43 Yang Liu 54 Xiao Fan 42

Jie Xia Phones & Addresses

Washington, DC   

540 Memorial Dr APT 1405, Cambridge, MA 02139   

Grandville, MI   

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Jie Xia Photo 21

Jie Xia

Location:
Cambridge, MA
Industry:
Environmental Services
Education:
Massachusetts Institute of Technology 2005 - 2009
Jie Xia Photo 22

Jie Xia

Location:
540 Memorial Dr, Cambridge, MA 02139
Industry:
Architecture & Planning
Education:
Massachusetts Institute of Technology 2009 - 2011
Jie Xia Photo 23

Jie Xia

Jie Xia Photo 24

Jie Xia

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Jie Xia

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Jie Xia

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Wikipedia

Jie Xia Photo 27

Jie Of Xia

King Jie (Chinese: ; pinyin: Ji 17281675 BCE) was the 17th and last ruler of the Xia dynasty of China. He is traditionally regarded as a tyrant and oppressor ...

Us Patents

Oligonucleotides Comprising A Modified Or Non-Natural Nucleobase

US Patent:
7579451, Aug 25, 2009
Filed:
Jul 21, 2005
Appl. No.:
11/186915
Inventors:
Muthiah Manoharan - Weston MA, US
Jie Xia - Carlsbad CA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/00
C07H 21/02
C07H 21/04
C12Q 1/68
US Classification:
536 231, 536 243, 536 2433, 435 6
Abstract:
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one non-natural nucleobase. In a preferred embodiment, the non-natural nucleobase is difluorotolyl.

Oligonucleotides Comprising A Ligand Tethered To A Modified Or Non-Natural Nucleobase

US Patent:
7632932, Dec 15, 2009
Filed:
Aug 4, 2005
Appl. No.:
11/197753
Inventors:
Muthiah Manoharan - Weston MA, US
Jie Xia - Carlsbad CA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/00
C07H 21/02
C07H 21/04
C12Q 1/68
US Classification:
536 231, 536 243, 536 2433, 435 6
Abstract:
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase.

Oligonucleotides Comprising A Modified Or Non-Natural Nucleobase

US Patent:
7772387, Aug 10, 2010
Filed:
Jul 1, 2009
Appl. No.:
12/495932
Inventors:
Muthiah Manoharan - Weston MA, US
Jie Xia - Carlsbad CA, US
Assignee:
Alnylam Pharmaceuticals - Cambridge MA
International Classification:
C07H 21/02
C07H 21/04
C12Q 1/68
US Classification:
536 241, 536 231, 536 243, 536 2433, 435 6
Abstract:
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one non-natural nucleobase. In a preferred embodiment, the non-natural nucleobase is difluorotolyl.

Oligonucleotides Comprising A Ligand Tethered To A Modified Or Non-Natural Nucleobase

US Patent:
7893224, Feb 22, 2011
Filed:
Jul 31, 2009
Appl. No.:
12/533710
Inventors:
Muthiah Manoharan - Weston MA, US
Jie Xia - Carlsbad CA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07G 3/00
C07H 21/04
C12Q 1/68
US Classification:
536 41, 536 231, 435 6
Abstract:
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase.

Possible Relatives

Eva Xia  Hua C Xia  Hui Z Xia  Jennifer Xia  Jin Xia  Katie Xia  Leon E Xia  Jie F Landers  Jie Meng  Jie Li 

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