Inventors:
B. Michael Butters - Lacey WA, US
John T. Butters - Del Mar CA, US
Christine Bonzon - San Diego CA, US
Marco Gymnopoulos - San Diego CA, US
Mayra Montes Camacho - National City CA, US
Assignee:
NATIVIS, INC. - La Jolla CA
International Classification:
A61K 31/337
A61K 9/127
A61P 35/00
A61K 31/7105
C12N 5/09
G01J 3/44
G01J 3/00
G01R 33/12
B82Y 5/00
US Classification:
424450, 514449, 514 44 A, 435375, 356301, 356 51, 324228, 977773
Abstract:
A method of forming an aqueous composition effective to produce an agent-specific effect on an agent-responsive chemical or biological system, when the composition is added to the system, is disclosed. The composition is formed by exposing an aqueous medium to a low-frequency, time-domain signal derived from the agent, until the aqueous medium acquires a detectable agent activity. Exemplary compositions are formed by exposure to a paclitaxel signal or a signal derived from a therapeutic oligonucleotide, such as GAPDH antisense RNA and PCSK9 antisense RNA. Also disclosed are methods for confirming the activity of the composition, and for preparing and testing the activity of the compositions.