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Us Patents

Apparatus And Method For Measuring Molecular Electromagnetic Signals With A Squid Device And Stochastic Resonance To Measure Low-Threshold Signals

US Patent:
6724188, Apr 20, 2004
Filed:
Mar 29, 2002
Appl. No.:
10/112927
Inventors:
John T. Butters - Langley WA
Bennett M. Butters - Lacey WA
Lisa C. Butters - Langley WA
Assignee:
Wavbank, Inc. - Seattle WA
International Classification:
G01R 3302
US Classification:
324248, 324239, 324261
Abstract:
An apparatus and method for the repeatable detection and recording of low-threshold molecular electromagnetic signals. The sample material and detection apparatus are contained with a magnetically shielded faraday cage to shield them from extraneous electromagnetic signals. The detection apparatus includes a detection coil and Super Conducting Quantum Interference Device (âSQUIDâ). White noise is injected external to the SQUID and the signals emitted by the sample material enhanced by stochastic resonance.

System And Method For Characterizing A Sample By Low-Frequency Spectra

US Patent:
7081747, Jul 25, 2006
Filed:
Aug 20, 2004
Appl. No.:
10/923545
Inventors:
John T. Butters - Langley WA, US
Bennett M. Butters - Lacey WA, US
Lisa C. Butters - Langley WA, US
Assignee:
Nativis, Inc. - La Jolla CA
International Classification:
G01R 33/02
US Classification:
324248, 324244, 702 75
Abstract:
A method and apparatus for interrogating a sample that exhibits molecular rotation are disclosed. In practicing the method, the sample is placed in a container having both magnetic and electromagnetic shielding, and Gaussian noise is injected into the sample. An electromagnetic time-domain signal composed of sample source radiation superimposed on the injected Guassian noise is detected, and this signal is cross-correlated with a second time-domain signal produced by the same or similar sample, to produce a cross-correlated signal with frequency domain components. The latter is plotted in the frequency domain by a fast Fourier transform to produce a frequency domain spectrum in a frequency range within DC to 50 KHz. From this spectrum, one or more low-frequency signal components that are characteristic of the sample being interrogated are identified.

Aqueous Compositions And Methods

US Patent:
2011019, Aug 11, 2011
Filed:
Dec 17, 2010
Appl. No.:
12/972089
Inventors:
B. Michael Butters - Lacey WA, US
John T. Butters - Del Mar CA, US
Christine Bonzon - San Diego CA, US
Marco Gymnopoulos - San Diego CA, US
Mayra Montes Camacho - National City CA, US
Assignee:
NATIVIS, INC. - La Jolla CA
International Classification:
A61K 31/337
A61K 9/127
A61P 35/00
A61K 31/7105
C12N 5/09
G01J 3/44
G01J 3/00
G01R 33/12
B82Y 5/00
US Classification:
424450, 514449, 514 44 A, 435375, 356301, 356 51, 324228, 977773
Abstract:
A method of forming an aqueous composition effective to produce an agent-specific effect on an agent-responsive chemical or biological system, when the composition is added to the system, is disclosed. The composition is formed by exposing an aqueous medium to a low-frequency, time-domain signal derived from the agent, until the aqueous medium acquires a detectable agent activity. Exemplary compositions are formed by exposure to a paclitaxel signal or a signal derived from a therapeutic oligonucleotide, such as GAPDH antisense RNA and PCSK9 antisense RNA. Also disclosed are methods for confirming the activity of the composition, and for preparing and testing the activity of the compositions.

Time-Domain Transduction Signals And Methods Of Their Production And Use

US Patent:
2013016, Jun 27, 2013
Filed:
Oct 26, 2012
Appl. No.:
13/662164
Inventors:
John T. Butters - Langley WA, US
Assignee:
Nativis, Inc. - Seattle WA
International Classification:
A61N 2/00
G01N 27/00
US Classification:
600 13, 324228
Abstract:
A storage medium having a low frequency time-domain signal stored thereon, and methods of generating, scoring, testing and using the signals are disclosed. In one general embodiment, the signal is derived from a taxane-like compound or an siRNA against human GADPH, and is useful in treating cancer in a subject by exposing the subject a low-magnetic field transduction of the signal. Also disclosed are improved signal transduction methods.

Systems And Methods For Measuring Magnetic Fields From Solvated Target Molecules Using A Magnetoresistive Sensor

US Patent:
2022029, Sep 22, 2022
Filed:
Mar 15, 2022
Appl. No.:
17/695482
Inventors:
- Seattle WA, US
John T. Butters - Seattle WA, US
International Classification:
A61N 2/02
A61K 41/00
G01N 27/74
Abstract:
A measurement system includes a container configured to contain a solvated target molecule and at least one magnetoresistive (MR) sensor device including at least one MR sensor disposed near the container and configured to measure a magnetic field generated by the solvated target molecule, each of the at least one MR sensor including a pin layer having a pinned direction of magnetization, a free layer having a direction of magnetization that varies with an applied magnetic field, and a non-conductive layer separating the pin layer and the free layer.

Time-Multiplexed Dual Atomic Magnetometry

US Patent:
2022021, Jul 7, 2022
Filed:
Mar 21, 2022
Appl. No.:
17/655654
Inventors:
- Seattle WA, US
John Butters - Seattle WA, US
International Classification:
G01R 33/26
G01R 33/032
Abstract:
Time-multiplexed atomic magnetometry uses first and second atomic vapor cells to measure an external magnetic field. Each vapor cell operates according to a sequence of alternating pumping and probing stages. However, the sequences are temporally offset from each other such that the second vapor cell is pumped while the first vapor cell is probed, and the first vapor cell is pumped while the second vapor cell is probed. With this time-multiplexed operation, the external magnetic field can be measured without any time gaps. The Hilbert transform of the signals may be taken to obtain their instantaneous phases, which may then be interleaved to form a single gapless time sequence that represents the external magnetic field over a time window that lasts for several continuous pumping/probing stages.

Systems And Methods For Therapy Delivery Using Near Field Magnetic Induction Devices

US Patent:
2021036, Nov 25, 2021
Filed:
May 13, 2021
Appl. No.:
17/320144
Inventors:
- Seattle WA, US
John T. Butters - Seattle WA, US
International Classification:
A61N 2/02
G16H 40/67
G16H 20/30
Abstract:
A therapy delivery system includes a near field magnetic induction (NFMI) transceiver device configured to be worn or otherwise disposed on a patient, the NFMI transceiver device including a NFMI transceiver; and a therapy delivery device including a NFMI receiver configured to receive signals from the NFMI transceiver device and a therapy delivery circuit configured to deliver a therapeutic magnetic signal, based, at least in part, on the received signals from the NFMI transceiver device, to the patient when the patient wears the therapy delivery device or has the therapy delivery device disposed on skin of the patient or has the therapy delivery device implanted.

Miniaturized Molecular Interrogation And Data System

US Patent:
2017006, Mar 9, 2017
Filed:
Jul 11, 2013
Appl. No.:
15/128938
Inventors:
- Seattle WA, US
John T. BUTTERS - Langley WA, US
International Classification:
G01R 33/032
G01N 27/72
Abstract:
A system for analyzing signals produced from a sample is described, where the system includes at least one magnetometer, where the magnetometer is capable of detecting magnetic fields produced by a sample. The magnetometer is positioned proximate to the sample, and is miniaturized (e.g. has a size less than 6 cm per side). A noise producing component is configured to uniformly produce noise surrounding the sample and the magnetometer, where the noise produced is capable of inducing stochastic resonance in the sample to amplify characteristic signals of the sample. At least one shielding structure electromagnetically shields the sample and the first magnetometer from external electromagnetic radiation

Isbn (Books And Publications)

Defending The Digital Frontier: Practical Security For Management

Author:
John Butters
ISBN #:
0471680877

Travel Industry Marketing

Author:
John P. Butters
ISBN #:
0931202191

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