John R Chiorini, 84210 Viewpoint Dr, Danville, CA 94506
John Chiorini Phones & Addresses
210 Viewpoint Dr, Danville, CA 94506 408-3916102
Burke, VA
Mi Wuk Village, CA
Syracuse, NY
1077 Sargent Dr, Sunnyvale, CA 94087 209-5862685 408-7201414
Sonora, CA
Twain Harte, CA
Tuolumne, CA
210 Viewpoint Dr, Danville, CA 94506 408-5926353
Work
Position:
Construction and Extraction Occupations
Education
Degree:
Bachelor's degree or higher
Mentions for John R Chiorini
Publications & IP owners
Us Patents
Lipid Vesicles Containing Adeno-Associated Virus Rep Protein For Transgene Integration And Gene Therapy
US Patent:
6342390, Jan 29, 2002
Filed:
Nov 23, 1994
Appl. No.:
08/344729
Inventors:
Stephen M. Wiener - Bethesda MD
John A. Chiorini - Silver Spring MD
Brian Safer - Silver Spring MD
Robert M. Kotin - Rockville MD
Matthew D. Weitzman - La Jolla CA
Roland A. Owens - Arlington VA
John A. Chiorini - Silver Spring MD
Brian Safer - Silver Spring MD
Robert M. Kotin - Rockville MD
Matthew D. Weitzman - La Jolla CA
Roland A. Owens - Arlington VA
Assignee:
The United States of America as represented by the Secretary of Health and Human Services - Washington DC
International Classification:
C12N 1500
US Classification:
435325, 4353201, 4353723, 435455, 435458, 514 2, 514 44, 424 931, 424 9321, 530350
Abstract:
A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest. Such a composition provides for integration of genetic material at a specific locus in the human chromosome, while minimizing the possibility of inadvertent inactivation of host genes and minimizing the possibility of viral contamination.
Methods Of Using Adeno-Associated Virus Rep Protein
US Patent:
6821511, Nov 23, 2004
Filed:
Aug 3, 2001
Appl. No.:
09/922327
Inventors:
Robert M. Kotin - Bethesda MD
Brian Safer - Silver Spring MD
John A. Chiorini - Silver Spring MD
Matthew D. Weitzman - La Jolla CA
Roland A. Owens - Arlington VA
Stephen M. Wiener - Boston MA
Brian Safer - Silver Spring MD
John A. Chiorini - Silver Spring MD
Matthew D. Weitzman - La Jolla CA
Roland A. Owens - Arlington VA
Stephen M. Wiener - Boston MA
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 4800
US Classification:
424 932, 424 9321, 435 691, 435 914, 4353201, 435325, 435455
Abstract:
A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest. Such a composition provides for integration of genetic material at a specific locus in the human chromosome, while minimizing the possibility of inadvertent inactivation of host genes and minimizing the possibility of viral contamination.
Aav5 Vector For Transducing Brain Cells And Lung Cells
US Patent:
6855314, Feb 15, 2005
Filed:
Mar 22, 2000
Appl. No.:
09/533427
Inventors:
John A. Chiorini - Kensington MD, US
Robert M. Kotin - Bethesda MD, US
Beverly Davidson - North Liberty IA, US
Joseph Zabner - Iowa City IA, US
Robert M. Kotin - Bethesda MD, US
Beverly Davidson - North Liberty IA, US
Joseph Zabner - Iowa City IA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
University of Iowa Research Foundation - Iowa City IA
University of Iowa Research Foundation - Iowa City IA
International Classification:
A01N063/00
A01N065/00
A01N043/04
C12N015/63
C12N015/85
A01N065/00
A01N043/04
C12N015/63
C12N015/85
US Classification:
424 932, 424 931, 424 936, 4353201, 435455, 514 44
Abstract:
The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic acids to cells of the CNS such as cerebellar cells and ependymal cells. The invention also provides methods of delivering nucleic acids to cells of the lung such as alveolar cells using AAV5 vectors and particles.
Aav5 Vector And Uses Thereof
US Patent:
6984517, Jan 10, 2006
Filed:
Nov 21, 2000
Appl. No.:
09/717789
Inventors:
John A. Chiorini - Kensington MD, US
Robert M. Kotin - Bethesda MD, US
Robert M. Kotin - Bethesda MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12N 15/864
C12N 15/63
C12N 15/64
C07H 21/04
C12N 15/63
C12N 15/64
C07H 21/04
US Classification:
4353201, 4352351, 536 231, 536 232, 536 2372, 536 241
Abstract:
The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV5 vectors and particles.
Aav5 Nucleic Acids
US Patent:
7479554, Jan 20, 2009
Filed:
Jul 19, 2005
Appl. No.:
11/184380
Inventors:
John A. Chiorini - Kensington MD, US
Robert M. Kotin - Bethesda MD, US
Robert M. Kotin - Bethesda MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07H 21/00
C07H 21/04
A61K 48/00
C07H 21/04
A61K 48/00
US Classification:
536 2372, 536 231, 536 237, 536 241, 4353201
Abstract:
The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV5 vectors and particles.
Bovine Adeno-Associated Viral (Baav) Vector And Uses Thereof
US Patent:
8137960, Mar 20, 2012
Filed:
Dec 6, 2004
Appl. No.:
10/581228
Inventors:
Michael Schmidt - Kensington MD, US
Ioannis Bossis - Columbia MD, US
John A. Chiorini - Dayton MD, US
Ioannis Bossis - Columbia MD, US
John A. Chiorini - Dayton MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12N 15/86
C12N 15/864
C12N 15/864
US Classification:
4353201
Abstract:
The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
Isolation, Cloning And Characterization Of New Adeno-Associated Virus (Aav) Serotypes
US Patent:
8283151, Oct 9, 2012
Filed:
May 1, 2006
Appl. No.:
11/912803
Inventors:
Michael Schmidt - Kensington MD, US
John A. Chiorini - Kensington MD, US
John A. Chiorini - Kensington MD, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC
International Classification:
C12N 7/00
C07K 2/00
C07H 23/00
C12Q 1/70
C07K 2/00
C07H 23/00
C12Q 1/70
US Classification:
4352351, 435 71, 4353201, 435 5, 530300, 530350, 5303871, 536 231, 536 2372
Abstract:
The present invention provides new adeno-associated virus (AAV) viruses and vectors, and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV vectors and particles.
Aav4 Vector And Uses Thereof
US Patent:
8507267, Aug 13, 2013
Filed:
Mar 8, 2010
Appl. No.:
12/719671
Inventors:
John A. Chiorini - Kensington MD, US
Robert M. Kotin - Bethesda MD, US
Nancy Safer - Silver Spring MD, US
Robert M. Kotin - Bethesda MD, US
Nancy Safer - Silver Spring MD, US
Assignee:
U.S. Dept. of Health and Human Services, National Institutes of Health - Washington DC
International Classification:
C12N 15/35
C12N 15/864
C12N 7/02
C12P 21/02
C07H 21/04
C12N 15/864
C12N 7/02
C12P 21/02
C07H 21/04
US Classification:
4353201, 435 701, 4352351, 536 2372
Abstract:
The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.
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