John Kenneth Critser, 62714 Andrea Dr, Beech Grove, IN 46107
John Critser Phones & Addresses
714 Andrea Dr, Beech Grove, IN 46107 317-7881428
90 6Th Ave, Beech Grove, IN 46107 317-7888956 317-7881428
4044 Redfern Dr, Indianapolis, IN 46237 317-7881428
3919 Redfern Dr, Indianapolis, IN 46237
Mitchell, IN
Gilbertsville, PA
Marion, IN
Mentions for John Kenneth Critser
Publications & IP owners
Us Patents
Systems And Methods For Cryopreservation Of Cells
US Patent:
7939316, May 10, 2011
Filed:
Jun 19, 2007
Appl. No.:
11/765000
Inventors:
Erik John Woods - Indianapolis IN, US
John K. Critser - Columbia MO, US
John K. Critser - Columbia MO, US
Assignee:
Bio Technology, LLC - Indianapolis IN
International Classification:
C12M 1/12
C12M 3/06
C12M 3/06
US Classification:
4353071, 4352971, 4352975, 624579
Abstract:
An auto-nucleating device includes a hollow tube containing a crystalline cholesterol matrix therein. The ends of the tube are closed by a membrane that is impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device is disposed within the vessel and provides a site for ice nucleation during freezing of the liquid within the vessel. One such cryopreservation vessel is a flexible vial having a closed port at one adapted to be pierced by a needle to withdraw the liquid within. The opposite end of the vial is initially open to receive the liquid. The end is then sealed to form a closed system for cryopreservation. Another cryopreservation vessel includes an adaptor mounted to a port of a liquid container. The adaptor includes one tubular branch that is closed by a needle septum while another tubular branch includes a barbed fitting for engaging a flexible tube. The flexible term terminates in a needle septum.
Systems And Methods For Cryopreservation Of Cells
US Patent:
8222027, Jul 17, 2012
Filed:
Dec 17, 2008
Appl. No.:
12/337237
Inventors:
Erik John Woods - Indianapolis IN, US
John K. Critser - Columbia MO, US
John K. Critser - Columbia MO, US
Assignee:
Cook General Biotechnolgy, LLC - Indianapolis IN
International Classification:
C12M 1/12
C12M 3/06
C12M 3/06
US Classification:
4353071, 4352971, 4352975, 624579
Abstract:
An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane that is impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the vessel. One such cryopreservation vessel is a flexible vial having a closed port at one adapted to be pierced by a needle to withdraw the liquid within, and an opposite end that is initially open to receive the liquid. Another vessel includes an adaptor mounted to liquid container with a tubular branch closed by a needle septum and another tubular branch provided with a barbed fitting for engaging a flexible tube that terminates in a needle septum. In another embodiment, the vessel includes an inlet and vent branch at the top of the container and an outlet septum at a bottom opening.
Systems And Methods For Cryopreservation Of Cells
US Patent:
2013006, Mar 14, 2013
Filed:
Jul 16, 2012
Appl. No.:
13/549609
Inventors:
Erik John Woods - Indianapolis IN, US
John K. Critser - Columbia MO, US
John K. Critser - Columbia MO, US
International Classification:
C12M 1/00
C12N 5/07
C12N 5/07
US Classification:
435374, 4353071
Abstract:
An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the vessel. The cryopreservation vessel can be a flexible vial having a closed port adapted to be pierced by a needle, and an opposite end that is initially open to receive the liquid. Another vessel includes an adaptor mounted to liquid container with a tubular branch closed by a needle septum and another tubular branch provided with a barbed fitting for engaging a flexible tube that terminates in a needle septum. Alternatively, the vessel includes an inlet and vent branch at the top of the container and an outlet septum at a bottom opening.
Enzymatic Method For Removal Of Cryoprotectants From Cryopreserved Animal Cells
US Patent:
6218101, Apr 17, 2001
Filed:
May 4, 1999
Appl. No.:
9/304404
Inventors:
John K. Critser - Carmel IN
Erik J. Woods - Indianapolis IN
Erik J. Woods - Indianapolis IN
Assignee:
General Biotechnology, LLC - Carmel IN
International Classification:
A01N 102
C07G 1700
C07K 100
C07G 1700
C07K 100
US Classification:
435 2
Abstract:
A method to remove cryoprotectants from cryopreserved biological cells and tissues is described. Enzymes are used to convert compounds used as cryoprotectants for cells during cryopreservation to membrane impermeable products. This process effectively removes the cryoprotectant chemicals from the cells prior to their use in transfusion, transplantation, insemination or other applications, without causing osmotic damage due to cell swelling. Methods are described for subsequent removal of the enzymes and enzyme conversion products from the cell and tissue preparations.
Step-Wise Method To Remove Cryoprotectant From Sperm
US Patent:
5595866, Jan 21, 1997
Filed:
May 27, 1994
Appl. No.:
8/250675
Inventors:
John K. Critser - Carmel IN
Dayong Gao - Indianapolis IN
Dayong Gao - Indianapolis IN
Assignee:
Methodist Hospital of Indiana, Inc. - Indianapolis IN
International Classification:
A01N 102
US Classification:
435 2
Abstract:
A mathematical model to optimize protocols for the addition or removal of cryoprotectant to or from sperm cells. This disclosure describes the use of four equations to predict optimal protocols to add or remove cryoprotectant to or from sperm cells. The equations particularly require experimentally found data, specific to a species of sperm, regarding the osmotic tolerance of sperm cells, where osmotic tolerance refers to the sperm cells ability to shrink or swell to various changes in osmolality without injury. The equations further require the cryoprotectant permeability coefficient and the water permeability coefficient of the particular sperm cells' plasma membrane. Also disclosed are two particularly preferred methods to add or remove cryoprotectant to or from sperm. These preferred methods are Fixed-Volume-Step addition/removal of cryoprotectant or Fixed-Molarity-Step addition/removal of cryoprotectant.
Cell-Type-Specific Methods And Devices For The Low Temperature Preservation Of The Cells Of An Animal Species
US Patent:
6054287, Apr 25, 2000
Filed:
Feb 27, 1998
Appl. No.:
9/032071
Inventors:
Dayong Gao - Indianapolis IN
John K. Critser - Carmel IN
John K. Critser - Carmel IN
Assignee:
Methodist Hospital of Indiana, Inc. - Indianapolis IN
International Classification:
C12Q 102
US Classification:
435 29
Abstract:
A mathematical model, the membranes and devices based upon that model to optimize protocols for the addition or removal of cryoprotectant to or from biological cells, and a method to observe the biological cells and obtain the data to implement the models. This disclosure describes the use of four equations to predict optimal protocols to add or remove cryoprotectant to or from biological cells. The equations particularly require experimentally found data, specific to cell-type and species, regarding the osmotic tolerance of the cells, where osmotic tolerance refers to the cells ability to shrink or swell to various changes in osmolality without injury. The equations further require the cryoprotectant permeability coefficient and the water permeability coefficient of the particular cells' plasma membrane. These coefficients are found with experimental data of the knetic volume change of the cell-type to a known concentration and temperature of cryoprotectant, and one method is particularly presented as to how this data may be obtained. Also disclosed are particularly preferred methods and devices to add or remove cryoprotectant to or from these cells based upon these equations.
General Method To Quickly Remove Cryoprotectants From Animal Cells While Maintaining Viability
US Patent:
5700632, Dec 23, 1997
Filed:
Jun 7, 1995
Appl. No.:
8/474477
Inventors:
John K. Critser - Carmel IN
D. Y. Gao - Indianapolis IN
D. Y. Gao - Indianapolis IN
Assignee:
Methodist Hospital of Indiana - Indianapolis IN
International Classification:
A01N 102
US Classification:
435 2
Abstract:
A mathematical model, and membranes and devices based upon that model, to optimize protocols for the addition or removal of cryoprotectant to or from biological cells. This disclosure describes the use of four equations to predict optimal protocols to add or remove cryoprotectant to or from biological cells. The equations particularly require experimentally found data, specific to cell-type and species, regarding the osmotic tolerance of the cells, where osmotic tolerance refers to the cells ability to shrink or swell to various changes in osmolality without injury. The equations further require the cryoprotectant permeability coefficient and the water permeability coefficient of the particular cells' plasma, membrane. These coefficients are found with experimental data of the knetic volume change of the cell-type to a known concentration and temperature of cryoprotectant. Also disclosed are particularly preferred methods and devices to add or remove cryoprotectant to or from these cells based upon these equations.
Sorbent Method For Removal Of Cryoprotectants From Cryopreserved Animal Cells
US Patent:
6235463, May 22, 2001
Filed:
May 6, 1999
Appl. No.:
9/306602
Inventors:
John K. Critser - Carmel IN
Erik J. Woods - Indianapolis IN
Erik J. Woods - Indianapolis IN
Assignee:
General Biotechnology, LLC - Carmel IN
International Classification:
A01N 102
C12N 500
C12N 500
US Classification:
435 2
Abstract:
A method is disclosed for removal of cryoprotectants from preserved suspension of biological cells and tissues. Sorbent materials are used, alone or in combination, to bind the cryoprotectant component of preserved cell suspensions with minimal osmotic stress on the preserved cells. The present method is used to effectively remove the cryoprotectants from cryopreserved cells and tissues prior to their use in transfusion, transplantation, insemination or other applications, with minimal osmotic damage due to cell swelling. Specific devices and methods are described.
Isbn (Books And Publications)
Reproductive Tissue Banking: Scientific Principles
Author:
John Kenneth Critser
ISBN #:
0123997704
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