John J Grzesiak, 69Springdale, UT
John Grzesiak Phones & Addresses
Virgin, UT
2111 Oxford Ave, Cardiff by the Sea, CA 92007
PO Box 790085, Virgin, UT 84779
Mentions for John J Grzesiak
Publications & IP owners
Us Patents
Laminin 5 For Growth Of Pancreatic Islet Cells
US Patent:
5672361, Sep 30, 1997
Filed:
Mar 29, 1996
Appl. No.:
8/626242
Inventors:
Craig Halberstadt - San Diego CA
John J. Grzesiak - Cardiff CA
John J. Grzesiak - Cardiff CA
Assignee:
Desmos, Inc. - San Diego CA
International Classification:
A61K 3539
A61K 3828
C12N 506
C12N 508
A61K 3828
C12N 506
C12N 508
US Classification:
424556
Abstract:
A method of expanding the number of pancreatic islet cells for transplantation. Fetal islet cells are cultured in the presence of laminin 5 extracellular matrix, resulting in a significant increase in cell number after passaging in culture. The expanded islet cells contain insulin and respond to glucose challenge.
Methods For Modifying The Binding Activity Of Cell Adhesion Receptors
US Patent:
5759855, Jun 2, 1998
Filed:
Aug 9, 1993
Appl. No.:
8/104335
Inventors:
Michael D. Pierschbacher - San Diego CA
John J. Grzesiak - Cardiff CA
Daniel Kirchhofer - Obervil, CH
John J. Grzesiak - Cardiff CA
Daniel Kirchhofer - Obervil, CH
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
C12N 506
A01N 5906
A61K 3306
A01N 5906
A61K 3306
US Classification:
435325
Abstract:
The invention relates to the regultory role of cations on the dynamics of integrin-mediated cell adhesion and migration. In one aspect, methods of promoting or inhibiting the migration of integrin-expressing cells are provided by controlling the amount of cations, such as Mg. sup. 2+ or Ca. sup. 2+, in contact with the integrins of the cells. Methods of modifying the binding avidity of an integrin for its ligand are also provided by regulating the concentration of cations in contact with the integrin. The invention further relates to methods of using cations for a variety of applications and in particular for promoting wound healing.
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