John P Mcgeehan, 864169 Main St, Philadelphia, PA 19127

5411858, May 2, 1995

Aug 12, 1993

8/104934

John K. McGeehan - Woodbury NJ
Gerhard Ertingshausen - Princeton NJ
Timothy B. Meluch - Bear DE

ActiMed Laboratories, Inc. - Burlington NJ

G01N 33531

435 4

A quantitative test device is manufactured using a feedback loop which allows one to modify continuously the dimensions of a reading scale printed on the device. The quantitative test device is manufactured by attaching the critical component of a two-component dye system to minute particles such as microcrystalline cellulose, silica, or latex, which particles are suspended in a solution of a polymeric binder. Additional non-immobilized components of the reaction system of the test device are optionally added to the polymer solution. The suspension of dyed particles in polymer solution is applied to a fabric as a coating, using conventional coating machines, to obtain a homogeneous distribution of immobilized dye throughout the fabric. The device includes a measurement zone which is made from a film support made of a material having a lower melting point than the filter cloth fabric used in the measurement zone was used. By using a lower melting point material for the support film, impulse heat sealing is controlled to a degree such that the lower melting point support is made to melt and extrude through the mesh of the fabric on either side of a channel, forming a seal along the sides of the channel.

5660798, Aug 26, 1997

Jun 7, 1995

8/482853

Sonal R. Doshi - Springfield PA
John K. McGeehan - Woodbury NJ
Wai Tak Law - Sewell NJ

ActiMed Laboratories, Inc. - Burlington NJ

B01L 1100

422101

Red blood cells are removed from whole blood or a fraction thereof by contacting whole blood with a combination of an agglutinating agent and nucleating particles to form clusters of red blood cells. High molecular weight polyethylene glycol may be added further to enhance agglutination. The clusters of red blood cells are much larger than the size of individual red blood cells, so that the clusters can easily be filtered through a porous medium. The plasma which is substantially free of red blood cells is further passed through a filter that optionally contains an additional agglutinating agent. Flow-delay means may be provided to return the fluid sample in contact with a regard for a predetermined time.

4820627, Apr 11, 1989

Mar 24, 1986

6/842968

John K. McGeehan - Woodbury NJ

EM Diagnostic Systems, Inc. - Gibbstown NJ

C12Q 100

435 4

A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an aqueous solution of labile biochemical, e. g. , an enzyme, onto small particles, e. g. , lower than 20 mesh, of an inert, completely water-soluble solid bulking agent, e. g. , mannitol; drying the resultant labile biochemical-coated bulking agent to the desired dryness; and then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.

5009994, Apr 23, 1991

Jan 12, 1989

7/296178

John K. McGeehan - Woodbury NJ

EM Diagnostic Systems, Inc. - Gibbstown NJ

C12Q 100

435 4

A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an aqueous solution of labile biochemical, e. g. , an enzyme, onto small particles, e. g. , lower than 20 mesh, of an inert, completely water-soluble solid bulking agent, e. g. , mannitol; drying the resultant labile biochemical-coated bulking agent to the desired dryness; and then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.

5234813, Aug 10, 1993

Aug 26, 1991

7/749521

John K. McGeehan - Woodbury NJ
Gerhard Ertingshausen - Princeton NJ

Actimed Laboratories, Inc. - Mount Laurel NJ

G01N 33543
G01N 33544

435 79

An analytical device for fluid samples includes a fluid sample well means connected to a sample initiation area in such a fashion that the assay will not commence unless sufficient sample is introduced into the sample well means to conduct the assay. Once sufficient sample has been deposited into the sample well means, the sample flows into an initiation area and the assay commences.

5766552, Jun 16, 1998

Feb 5, 1996

8/596828

Sonal R. Doshi - Springfield PA
John K. McGeehan - Woodbury NJ
Wai Tak Law - Sewell NJ

ActiMed Laboratories, Inc. - Burlington NJ

G01N 128
B01L 1100

422101

Red blood cells are removed from whole blood or a fraction thereof by agglutinating whole blood with a mixture of a free agglutinating agent and nucleating particles having agglutinating agent intimately associated therewith to form clusters of red blood cells. High molecular weight polyethylene glycol may be added further to enhance agglutination. The clusters of red blood cells are much larger than the size of individual red blood cells, so that the clusters can easily be filtered through a porous medium. The plasma, which is substantially free of red blood cells, is further passed through a filter that optionally contains an additional agglutinating agent. Flow-delay additives may be provided to retain the fluid sample in contact with a reagent for a predetermined time.

5652148, Jul 29, 1997

Apr 20, 1993

8/049862

Sonal R. Doshi - Springfield PA
John K. McGeehan - Woodbury NJ
Wai Tak Law - Sewell NJ

Actimed Laboratories, Inc. - Burlington NJ

B01D 2101

436178

Red blood cells are removed from whole blood or a fraction thereof by contacting whole blood with a combination of an agglutinating agent and nucleating particles to form clusters of red blood cells. High molecular weight polyethylene glycol may be added further to enhance agglutination. The clusters of red blood cells are much larger than the size of individual red blood cells, so that the clusters can easily be filtered through a porous medium. The plasma which is substantially free of red blood cells is further passed through a filter that optionally contains an additional agglutinating agent.