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John A Musachio, 82Hoffman Estates, IL

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Lake in the Hills, IL   

Elmhurst, IL   

47 Stirling Ln, Clarendon Hills, IL 60514    630-6544828   

Willowbrook, IL   

La Grange, IL   

Lake in the Hills, IL   

Chicago, IL   

La Grange, IL   

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Us Patents

Ligands For Nicotinic Acetylcholine Receptors, And Methods Of Making And Using Them

US Patent:
8030300, Oct 4, 2011
Filed:
Jun 9, 2004
Appl. No.:
10/558607
Inventors:
Alan P. Kozikowski - Chicago IL, US
John L. Musachio - Baltimore MD, US
Kenneth J. Kellar - Bethesda MD, US
Yingxian Xiao - Potomac MD, US
Zhi-Liang Wei - Chicago IL, US
Hong Fan - Timonium MD, US
Assignee:
Georgetown University - Washington DC
The John Hopkins University - Baltimore MD
International Classification:
A61K 31/4427
C07D 401/12
US Classification:
5142102, 5462681
Abstract:
One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. The present invention also relates to the use of a compound of the invention for treating a mammal suffering from Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism or trichtillomania.

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