John Spicuzza resumes & CV records
Resumes
John Spicuzza
John D Spicuzza Deceased2000 Knollwood Rd, Lake Forest, IL 60045
John Spicuzza Phones & Addresses
Lake Forest, IL
4611 Larkin St, Milwaukee, WI 53211 414-9627783
9301 76Th St, Milwaukee, WI 53223
Whitefish Bay, WI
Mentions for John D Spicuzza
Publications & IP owners
Us Patents
Stable Hemoglobin Based Composition And Method To Store Same
US Patent:
5352773, Oct 4, 1994
Filed:
Oct 16, 1992
Appl. No.:
7/962623
Inventors:
Richard L. Kandler - McHenry IL
John C. Spicuzza - Highland Park IL
John C. Spicuzza - Highland Park IL
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
C07K 1300
A61K 3514
A61K 3700
C07C10352
A61K 3514
A61K 3700
C07C10352
US Classification:
530385
Abstract:
The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5. degree. C. to 45. degree. C. for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemoglobin based solution cannot have greater than about 50% of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15%. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.
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