John Kenneth Suh, 58330 E 38Th St APT 15F, New York, NY 10016

4491582, Jan 1, 1985

Mar 3, 1983

6/471594

Bernard Loev - Scarsdale NY
Howard Jones - Ossining NY
John T. Suh - Greenwich CT

USV Pharmaceutical Corporation - Tarrytown NY

C07D40306
A61K 31495

424250

1,4-Dihydropyridine carboxylic acid esters of the formula: ##STR1## wherein Ar is heteroaryl selected from the group consisting of thiophene, furan, pyridine, thiazole, pyrimidine, pyrrole, benzofuran, quinoline and benzothiophene, cycloalkyl having from 3 to 7 carbon atoms, naphthyl, indanyl, indenyl, tetrahydronaphthyl, or a radical of the formula ##STR2## wherein each of R. sub. 5, R. sub. 6 and R. sub. 7 is independently H, alkyl, phenyl, tolyl, naphthyl, halo, lower alkoxy, nitro, amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, methanesulfonyl, or alkylamino and R. sub. 5 and R. sub. 6 when taken together, form a methylenedioxy; Z is alkylene containing 1 to about 5 carbon atoms in the principal chain; each R. sub. 1 is independently hydrogen, alkyl or alkoxyalkyl, with the proviso that only one R. sub. 1 may be hydrogen; R. sub.

4703037, Oct 27, 1987

Feb 18, 1986

6/830422

Fu-chih Huang - Boonton NJ
John T. Suh - Greenwich CT
Jerry W. Skiles - Tuckahoe NY

Rorer Pharmaceutical Corporation - Fort Washington PA

A61K 3702
C07D21700
C07C 6106
C07C 6104
C07C 6108

514 19

Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

4585758, Apr 29, 1986

Jan 10, 1985

6/690386

Fu-chih Huang - Boonton NJ
John T. Suh - Greenwich CT
Jerry W. Skiles - Tuckahoe NY

USV Pharmaceutical Corp. - Tarrytown NY

A61K 3147
A61K 3764
C07K 506
C07D21706

514 19

Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

4354027, Oct 12, 1982

May 19, 1980

6/151220

Bernard Loev - Scarsdale NY
John T. Suh - Greenwich CT
Bruce E. Williams - Cottage Grove MN
Vassil St. Georgiev - New Rochelle NY

USV Pharmaceutical Corporation - Tarrytown NY

C07D48704
C07D24144
C07D49114
A61K 31495

544346

New substituted triazoloquinoxalin-4-ones are described as well as the use thereof as anti-hypertensive agents.

4496542, Jan 29, 1985

Apr 13, 1983

6/484729

Jerry W. Skiles - Tuckahoe NY
Raymond D. Youssefyeh - Tarrytown NY
John T. Suh - Greenwich CT
Howard Jones - Ossining NY

USV Pharmaceutical Corporation - Tarrytown NY

A61K 3700
A61K 3140
A61K 31425
C07C10352
C07D40300
C07D23366
C07D23328
C07D23300
C07D23504
C07D40500
C07D21172
C07D21156
C07D21130
C07D21500
C07D22102
C07D41500
C07D41300
C07D26530
C07D27910

514 2

Compounds of the formula ##STR1## wherein R and R. sub. 9 are independently hydroxy and lower alkoxy, R. sub. 1 and R. sub. 2 are independently hydrogen, lower alkyl, aryl-lower alkyl having from 7 to 12 carbon atoms, or heterocyclic-lower alkyl having from 6 to 12 carbon atoms, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 7 and R. sub. 8 are hydrogen or lower alkyl, R. sub. 6 is heterocyclic and their pharmaceutically acceptable, nontoxic acid addition salts and where R or R. sub. 9 or both are hydroxy, their pharmaceutically acceptable, nontoxic basic salts, possess antihypertensive activity.

4686295, Aug 11, 1987

Mar 7, 1983

6/472551

Raymond D. Youssefyeh - Tarrytown NY
Jerry W. Skiles - Tuckahoe NY
John T. Suh - Greenwich CT
Howard Jones - Ossining NY

USV Pharmaceutical Corporation - Fort Washington PA

C07D26344

548226

This invention relates to new compounds of the formula ##STR1## wherein A is a hydroxy, lower alkoxy, lower alkenoxy, diloweralkylamino lower alkoxy, acylamino lower alkoxy, acyloxy, lower alkoxy, aryloxy, arloweralkyloxy, amino, loweralkylamino, diloweralkylamino, aryloweralkylamino, hydroxyamino, or substituted aryloxy, or substituted arloweralkoxy wherein the substituent is methyl, halo or methoxy; R. sub. 1, R. sub. 2, and R. sub. 3 are each hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused aryl-cycloalkyl, aralkyl, cycloalkyl, heterocyclic, substituted alkyl, alkenyl, or alkynyl groups in which the substituents are hydroxy, alkoxy, halo, amino, aminoalkyl, alkylamino, mercapto, or alkylmercapto, substituted cycloalkyl groups in which the substituents are alkyl, halo, haloalkyl, hydroxy, alkylamino, nitro or trifluoromethyl, and substituted aryl and heterocyclic groups in which the substituents are alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, mercapto, alkylmercapto, mercaptoalkyl, haloalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, or trifluoromethyl; X is hydrogen, alkyl, alkenyl or alkynyl of up to about 20 carbon atoms, aryl or aryl lower alkyl containing from about 7 to about 12 carbon atoms, heterocyclic or heterocyclic lower alkyl cycloalkyl or cycloalkylalkyl containing up to about 20 carbon atoms, or of the formula: ##STR2## wherein n=2, 3 or 4; n'=1, 2 or 3; and Ar is arylene or mono- or di- substituted arylene in which the substituent is halo, CF. sub. 3, lower alkyl, OH, lower alkoxy, mercapto, amino or sulfanyl. These compounds are important intermediates in the syntheses of dipeptides which are useful in the treatment of hypertension and are effective as inhibitors of angiotensin converting enzymes.

4820729, Apr 11, 1989

Mar 30, 1981

6/248172

Raymond D. Youssefyeh - Tarrytown NY
Jerry W. Skiles - Tuckahoe NY
John T. Suh - Greenwich CT
Howard Jones - Ossining NY

Rorer Pharmaceutical Corporation - Fort Washington PA

A61K 31215
A61K 31195
C07C10102
C07C10172
C07C 6108

514542

Compounds of the formula ##STR1## wherein R and R. sub. 9 are independently hydroxy or lower alkoxy, R. sub. 1 and R. sub. 2 are hydrogen or lower alkyl, aryl-lower alkyl having from 7 to 12 carbon atoms, or heterocyclic-lower alkyl having from 6 to 12 carbon atoms, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 7 and R. sub. 8 are hygrogen or lower alkyl, R. sub. 6 is cycloalkly having from 3 to 20 carbon atoms, aryl or aryl-lower alkyl, and the aryl group contains from 6 to 10 carbon atoms, and their pharmaceutically acceptable, nontoxic acid addition salts and where R or R. sub. 9 or both are hydroxy, their pharmaceutically acceptable, nontoxic basic salts possess antihypertensive activity.

4831184, May 16, 1989

Feb 14, 1983

6/465940

Raymond D. Youssefyeh - Tarrytown NY
Jerry W. Skiles - Tuckahoe NY
John T. Suh - Greenwich CT
Howard Jones - Ossining NY

Rorer Pharmaceutical Corporation - Ft. Washington PA

C07C10144
C07C 6976
C07C 6974
C07C 6108

560 43

This invention relates to new chemical compounds having valuable pharmaceutical activity. It particularly relates to stereoisomeric compounds possessing hypotensive activity, i. e. , angiotensin converting enzyme inhibitory (ACEI) activity and having the structure ##STR1## wherein R and R. sub. 9 are independently hydroxy, lower alkoxy, lower alkenoxy, di(lower alkyl)amino-lower alkoxy, hydroxy-lower alkoxy, acylamino-lower alkoxy, acryloxy-lower alkoxy, aryloxy, aryloxyl-lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxyamino, or aryl-lower alkylamino; R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 7 and R. sub. 8 are independently hydrogen, alkyl, alkenyl or alkynyl containing up to 20 carbon atoms, aryl or aryl-lower alkyl having from 7 to 12 carbon atoms, heterocyclic or heterocyclic-lower alkyl having from 6 to 12 carbon atoms, cycloalkyl or cycloalkyl-alkyl containing up to 20 carbon atoms in the cycloalkyl group, provided that each of R. sub. 1 and R. sub. 2 and R. sub. 4 and R. sub. 5 are different; R. sub. 2 and R. sub. 3 taken together with the carbon and nitrogen to which they are respectively attached and R. sub. 3 and R. sub.