Inventors:
Jeffrey R. Idle - Roztoky, CZ
Frank J. Gonzalez - Bethesda MD, US
John B. Tyburski - Gaithersburg MD, US
Kristopher W. Krausz - Bethesda MD, US
Andrew David Patterson - Montgomery Village MD, US
International Classification:
A61K 31/195
C07C 63/06
C07C 229/02
C07H 19/06
C07C 309/03
C07D 473/04
C07H 19/16
G01N 33/48
G01N 33/68
C12Q 1/02
G01N 33/00
A61P 43/00
G01N 27/447
US Classification:
514562, 562426, 562553, 536 2853, 562104, 544267, 536 2721, 536 285, 436 98, 436 94, 436120, 436 89, 435 29, 422 681, 536 284, 204461
Abstract:
Disclosed herein are biomarkers for determining gamma radiation exposure by an animal or human. The biomarkers include 3-hydroxy-2-methylbenzoic acid 3-O-sulfate, N-hexanoylglycine, β-thymidine, taurine, xanthine, xanthosine, 2′-deoxyuridine, 2′-deoxycytidine, 2′-deoxyxanthosine, or any salt, ion, or combination thereof. Also disclosed are methods for determining gamma radiation exposure by an animal or human, which include the step of measuring the amount of one or more biomarkers specific to gamma radiation in the biological fluid and correlating the amount of said biomarkers to the amount of gamma radiation exposure by the animal or human. Systems for determining gamma radiation exposure by an animal or human and methods of treating an animal or human for gamma radiation exposure are also disclosed.