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John S Wai, 65208 Tanglewood Way, Harleysville, PA 19438

Known as:
John Suiman
Related to:
Rebecca Wai 31 Andrew C Wai 33

John Wai Phones & Addresses

208 Tanglewood Way, Harleysville, PA 19438    215-3680515   

Lansdale, PA   

Olympia Fields, IL   

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Position: Professional/Technical

Education

Degree: High school graduate or higher
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John Wai

John Wai (born July 30, 1947) is a Hong Kong sprint canoer who competed in the mid 1970s. He was eliminated in the repechages of the K-4 1000 m event at ...

Us Patents

Hiv Integrase Inhibitors

US Patent:
6380249, Apr 30, 2002
Filed:
Jun 1, 1999
Appl. No.:
09/323417
Inventors:
Steven D. Young - Lansdale PA
Melissa Egbertson - Ambler PA
Linda S. Payne - Lansdale PA
John S. Wai - Harleysville PA
Thorsten E. Fisher - Hatfield PA
Mark W. Embrey - North Wales PA
Lekhanh Tran - Norristown PA
Linghang Zhuang - Conshohocken PA
Joseph P. Vacca - Telford PA
H. Marie Langford - Lansdale PA
Jeffrey Melamed - Warminster PA
Juan C. Jaen - Burlingame CA
David L. Clark - Albany CA
Julio C. Medina - Belmont CA
Assignee:
Merck Co., Inc. - Rahway NJ
Tularik Inc. - S. San Francisco CA
International Classification:
A61K 31215
US Classification:
514530, 514531, 514538, 514539, 514541, 560 19, 560 48, 560 51, 560 53, 562426, 562433, 562441, 562451, 562452, 562457, 562459, 562462, 562463
Abstract:
Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Aza-And Polyaza-Naphthalenyl-Carboxamides Useful As Hiv Integrase Inhibitors

US Patent:
6919351, Jul 19, 2005
Filed:
Oct 9, 2001
Appl. No.:
10/399083
Inventors:
Neville J. Anthony - Chalfont PA, US
Robert P. Gomez - Perkasie PA, US
Steven D. Young - Lansdale PA, US
Melissa S. Egbertson - Ambler PA, US
John S. Wai - Harleysville PA, US
Jennifer J. Bennett - Lansdale PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K031/4375
A61K031/502
A61K031/5415
C07D471/04
C07D417/12
US Classification:
514300, 5142252, 5142258, 514248, 514314, 546123, 546169, 544 42, 544 43, 544 46, 544236, 544237, 544184, 544279
Abstract:
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

Aza- And Polyaza-Naphthalenyl Carboxamides Useful As Hiv Integrase Inhibitors

US Patent:
6921759, Jul 26, 2005
Filed:
Oct 10, 2001
Appl. No.:
09/973853
Inventors:
Neville J. Anthony - Hatfield PA, US
Robert P. Gomez - Perkasie PA, US
Steven D. Young - Lansdale PA, US
Melissa Egbertson - Ambler PA, US
John S. Wai - Harleysville PA, US
Linghang Zhuang - Chalfont PA, US
Mark Embrey - North Wales PA, US
Jeffrey Y. Melamed - Doylestown PA, US
H. Marie Langford - Lansdale NJ, US
James P. Guare - Quakertown PA, US
Thorsten E. Fisher - Hatfield PA, US
Samson M. Jolly - Quakertown PA, US
Michelle S. Kuo - Gwynedd Valley PA, US
Debra S. Perlow - East Greenville PA, US
Jennifer J. Bennett - East Norriton PA, US
Timothy W. Funk - Ephrata PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61P031/00
A61K031/4375
C07D471/02
US Classification:
51421103, 51421108, 514218, 5142222, 5142225, 5142282, 5142345, 514249, 51425304, 514274, 514275, 514300, 514303, 540488, 540489, 540492, 540545, 544 3, 544 8, 544 586, 544127, 544310, 544331, 544349, 544362, 546118, 546 9, 546123
Abstract:
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

N-(Substituted Benzyl)-8-Hydroxy-1,6-Naphthyridine-7-Carboxamides Useful As Hiv Integrase Inhibitors

US Patent:
7323460, Jan 29, 2008
Filed:
Mar 12, 2003
Appl. No.:
10/508094
Inventors:
Melissa Egbertson - Ambler PA, US
H. Marie Langford - Lansdale PA, US
Jeffrey Y. Melamed - Warminster PA, US
John S. Wai - Harleysville PA, US
Wei Han - West Chester PA, US
Debbie S. Perlow - East Greenville PA, US
Linghang Zhuang - Chalfont PA, US
Mark Embrey - North Wales PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 401/02
A61K 31/4375
US Classification:
5142222, 544 3, 544 8, 544127, 546123, 5142225, 5142345, 514300
Abstract:
N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I):.

8-Hydroxy-1-Oxo-Tetrahydropyrrolopyrazine Compounds Useful As Hiv Integrase Inhibitors

US Patent:
7399763, Jul 15, 2008
Filed:
Sep 10, 2003
Appl. No.:
10/526280
Inventors:
John S. Wai - Harleysville PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 241/36
A61K 31/498
US Classification:
514249, 544349
Abstract:
8-Hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds are inhibitors of HIV integrase and inhibitors of HIV replication. More particularly, the compounds are of Formula (I): wherein R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by ITV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.

Hydroxy Pyridopyrrolopyrazine Dione Compounds Useful As Hiv Integrase Inhibitors

US Patent:
7435735, Oct 14, 2008
Filed:
Oct 18, 2004
Appl. No.:
10/576328
Inventors:
John S. Wai - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Linghang Zhuang - Chalfont PA, US
Donnette D. Staas - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Boyoung Kim - Lansdale PA, US
Mark W. Embrey - North Wales PA, US
Catherine M. Wiscount - Allentown PA, US
Lekhanh O. Tran - Norristown PA, US
Melissa Egbertson - Ambler PA, US
Kelly L. Savage - Schwenksville PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 471/00
C07D 487/00
C07D 241/36
US Classification:
514250, 544345
Abstract:
Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R, R, R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Hiv Integrase Inhibitors

US Patent:
7476666, Jan 13, 2009
Filed:
Jun 3, 2005
Appl. No.:
11/629153
Inventors:
John S. Wai - Harleysville PA, US
Peter D. Williams - Harleysville PA, US
H. Marie Langford - Lansdale PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 487/04
C07D 413/06
C07D 471/04
A61K 31/55
A61K 31/535
A61K 31/495
A61P 31/18
US Classification:
514221, 5142332, 514250, 540502, 544117, 544346, 544350
Abstract:
Bicyclic pyrazoles of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:.

Dihydroxypyridopyrazine-1,6-Dione Compounds Useful As Hiv Integrase Inhibitors

US Patent:
7517532, Apr 14, 2009
Filed:
Sep 10, 2003
Appl. No.:
10/526275
Inventors:
John S. Wai - Harleysville PA, US
Boyoung Kim - Lansdale PA, US
Thorsten E. Fisher - Hatfield PA, US
Peter D. Williams - Harleysville PA, US
H. Marie Langford - Lansdale PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 39/21
C07D 241/00
C07D 241/02
C07D 241/36
C07D 471/00
C07D 487/00
C07D 491/00
C07D 495/00
C07D 497/00
US Classification:
4242081, 544336, 544349, 544350
Abstract:
8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.

Possible Relatives

Eleanor Wai  Ho C Wai  Honyin S Wai  Horace H Wai  James K Wai  Khin M Wai  Kyaw M Wai  John M Johnson  John Stamps  John R Stan 

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