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John T Wai, 8720 Confucius Plz, New York, NY 10002

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20 Confucius Plz, New York, NY 10002    212-4318295   

20 Confucius Plz #8F, New York, NY 10002    212-4318295   

Woodridge, NY   

Fallsburg, NY   

Sullivan, NY   

Flushing, NY   

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John Wai

John Wai (born July 30, 1947) is a Hong Kong sprint canoer who competed in the mid 1970s. He was eliminated in the repechages of the K-4 1000 m event at ...

Us Patents

Substituted Quinolizine Derivatives Useful As Hiv Integrase Inhibitors

US Patent:
2018002, Feb 1, 2018
Filed:
Oct 5, 2017
Appl. No.:
15/725407
Inventors:
- Rahway NJ, US
Yonglian Zhang - Metuchen NJ, US
Sherman Tim Waddell - Westfield NJ, US
Andrew Stamford - Chatham NJ, US
John S. Wai - Harleysville PA, US
Paul J. Coleman - Harleysville PA, US
John M. Sanders - Collegeville PA, US
Ronald Ferguson - Scotch Plains NJ, US
Thomas H. Graham - Quincy MA, US
Hong Li - Edison NJ, US
Assignee:
MERCK SHARP & DOHME CORP. - Rahway NJ
International Classification:
A61K 31/4375
C07D 519/00
A61K 31/52
A61K 31/513
A61K 31/505
A61K 31/4745
A61K 31/4402
A61K 31/427
A61K 31/635
A61K 31/444
C07D 455/00
C07D 455/04
C07D 471/14
C07D 491/147
A61K 45/06
A61K 31/675
C07D 455/02
Abstract:
The present invention relates to Substituted Quinolizine Derivatives of Formula (I):and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R, R, R, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

Spirocyclic Hetercycle Compounds Useful As Hiv Integrase Inhibitors

US Patent:
2016031, Nov 3, 2016
Filed:
Dec 17, 2014
Appl. No.:
15/105376
Inventors:
Thomas H. Graham - Scotch Plains NJ, US
Wensheng Liu - Edison NJ, US
Tao Yu - Edison NJ, US
Yonglian Zhang - Metuchen NJ, US
Sherman T. Waddell - Westfield NJ, US
John S. Wai - Harleysville PA, US
Paul J. Coleman - Harleysville PA, US
John M. Sanders - Hatfield PA, US
Mark W. Embrey - Harleysville PA, US
Abbas M. Walji - Lansdale PA, US
Christine Ng Di Marco - Conshohocken PA, US
Thomas G. Steele - Schwenksville PA, US
Lihong Hu - Shanghai, CN
Xuanjia Peng - Shanghai, CN
Assignee:
MERCK SHARP & DOHME CORP. - RAHWAY NJ
International Classification:
A61K 31/53
A61K 45/06
C07D 471/22
A61K 31/675
C07D 491/20
A61K 31/55
A61K 31/499
C07F 9/6561
C07D 471/20
C07D 495/20
Abstract:
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Substituted Quinolizine Derivatives Useful As Hiv Integrase Inhibitors

US Patent:
2016022, Aug 11, 2016
Filed:
Sep 26, 2014
Appl. No.:
15/025038
Inventors:
- Rahway NJ, US
Yonglian Zhang - Metuchen NJ, US
Sherman Tim Waddell - Westfield NJ, US
Andrew Stamford - Chatham NJ, US
John S. Wai - Harleysville PA, US
Paul J. Coleman - Harleysville PA, US
John M. Sanders - Collegeville PA, US
Ronald Ferguson - Scotch Plains NJ, US
Assignee:
MERCK SHARP & DOHME CORP. - Rahway NJ
International Classification:
A61K 31/4375
C07D 455/02
C07D 519/00
C07D 471/14
A61K 31/444
C07D 455/04
C07D 455/00
A61K 45/06
C07D 491/147
Abstract:
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R, R, R, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

4-Pyridinonetriazine Derivatives As Hiv Integrase Inhibitors

US Patent:
2015032, Nov 19, 2015
Filed:
Dec 12, 2013
Appl. No.:
14/652580
Inventors:
- Rahway NJ, US
Thomas H. Graham - Scotch Plains NJ, US
Abbas Walji - Lansdale PA, US
Sherman T. Waddell - Wesetfield NJ, US
Tao Yu - Edison NJ, US
Yonglian Zhang - Metuchen NJ, US
Wensheng Liu - Edison NJ, US
Paul J. Coleman - Harleysville PA, US
John Wai - Harleysville PA, US
Thomas Steele - Schwenksville PA, US
Christina Di Marco - Lafayette Hill PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 471/04
C07D 471/10
C07D 471/20
A61K 45/06
A61K 31/675
C07D 471/14
A61K 31/55
A61K 31/4985
A61K 31/53
C07F 9/6521
Abstract:
The present invention relates to 4-Pyridinonetriazine Derivatives of Formula (I); and pharmaceutically acceptable salts thereof, wherein A, X, Y, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one 4-Pyridinonetriazine Derivative, and methods of using the 4-Pyridinonetriazine Derivatives for treating or preventing HIV infection in a subject.

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