Jonathan L Gross, 59601 Swain Ct, Montgomery, NJ 08502

6617327, Sep 9, 2003

Apr 23, 2002

10/128722

Jonathan L. Gross - Robbinsville NJ
Gary P. Stack - Ambler PA

Wyeth - Madison NJ

A61K 314985

514250, 544345

Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

6667322, Dec 23, 2003

Oct 4, 2002

10/264376

Jonathan Laird Gross - Robbinsville NJ
Richard Eric Mewshaw - King of Prussia PA
Gary Paul Stack - Ambler PA

Wyeth - Madison NJ

A61K 314439

514338, 514321, 514300, 5462774, 546197, 546113

Compounds of the formula useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

6689905, Feb 10, 2004

Jun 27, 2002

10/185466

Reinhardt Bernhard Baudy - Buckingham PA
Jean Yi-ching Sze - Monmouth Junction NJ
Jonathan Laird Gross - Robbinsville NJ

Wyeth - Madison NJ

C07C 6112

562499

This invention provides a process for the preparation of all four stereoisomers of formula I or a pharmaceutically acceptable salt thereof which may be represented by the following structures:.

6700001, Mar 2, 2004

Oct 4, 2002

10/264947

Jonathan L. Gross - Robbinsville NJ
Gary P. Stack - Ambler PA

Wyeth - Madison NJ

C07D31158

549407, 549389, 546 89

A process for the stereoselective synthesis of 2-hydroxymethyl-chromans of formula (II) is provided where R, R , R and R are as defined herein. The compound of formula (II) is prepared using an optically active benzene compound of formula (I) where R is as defined herein. The 2-hydroxymethyl-chroman compounds of formula (II) are useful as intermediates for preparing a variety of medicinal agents.

6716998, Apr 6, 2004

Oct 4, 2002

10/264528

Jonathan L. Gross - Robbinsville NJ

Wyeth - Madison NJ

C07D31104

549398, 549399, 549405

This invention provides a process for the stereospecific preparation of 2-yl-chroman and -chromene derivatives of the formula: These compounds are useful for the preparation of optically active 2-aminomethyl- and 2-azaheterocyclylmethyl-chromans.

6750364, Jun 15, 2004

Jun 27, 2002

10/185489

Gary Paul Stack - Ambler PA
John Dunlop - Allentown NJ
Alexander Alexei Greenfield - Princeton Junction NJ
Jonathan Laird Gross - Robbinsville NJ

Wyeth - Madison NJ

C07D31178

560117, 549386, 562499, 514454, 514530, 514531

This invention provides compounds of the formula: wherein X is (CH ) , O, S, SO, SO or CR R ; n is 1 or 2; R and R are H, halogen, hydroxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or R and R , taken together form cycloalkyl of 3 to 6 carbon atoms, an alkylidene of up to 6 carbon atoms or a carbonyl; R , R and R are H or alkyl of 1 to 6 carbon atoms; Z is H, alkyl of 1 to 6 carbon atoms, alkanoyl of 1 to 6 carbon atoms or alkoxycarbonyl of 2 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods for their use in treating or preventing characterized by glutamate hypofunction, including schizophrenia, schizoaffective disorder and schizophreniform disorder, and for the treatment of cognitive deficits due to aging, stroke, Alzheimers disease or other neurodegenerative diseases.

6821981, Nov 23, 2004

Apr 25, 2002

10/131997

Gary P. Stack - Ambler PA
Megan Tran - Hoboken NJ
Jonathan L. Gross - Robbinsville NJ
George E. M. Husbands - Berwyn PA

Wyeth - Madison NJ

C07D49104

514278, 514291, 546 20, 546 90

Compounds of the formula useful for the treatment of disorders, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior.

7008944, Mar 7, 2006

Jul 14, 2003

10/618947

Jonathan L. Gross - Cranbury NJ, US
Gary P. Stack - Ambler PA, US

Wyeth - Madison NJ

A01N 43/58
A01N 43/60
A61K 31/495
A61K 31/50

514250

Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.